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MONDOA forms heterodimers with MLX (MIM 602976) that can bind to and activate transcription from CACGTG E boxes (Billin et al., 2000 [PubMed 11073985]).[supplied by OMIM, Mar 2008].. Zusätzlich bieten wir Ihnen MLX Interacting Protein Antikörper (31) und MLX Interacting Protein Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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MondoA-directed programs have a key role in the coordinated control of myocyte lipid balance and insulin (zeige INS Proteine) signaling
Evaluation of the conservation of ChREBP (zeige MLXIPL Proteine) and MondoA sequences demonstrate that MondoA is better conserved and potentially mediates more ancient function in glucose metabolism.
These results suggest that C771G polymorphism of MLXIPL (zeige MLXIPL Proteine) gene is associated with coronary stenosis and its severity.
Knockdown of MondoA, or its dimerization partner Mlx (zeige MLX Proteine), blocks Myc (zeige MYC Proteine)-induced reprogramming of multiple metabolic pathways, resulting in apoptosis
regulatory relationship between mTOR (zeige FRAP1 Proteine) and the MondoA-TXNIP (zeige TXNIP Proteine) axis that we propose contributes to glucose homeostasis
Suppression of Txnip (zeige TXNIP Proteine) by lipopolysaccharide is accompanied by a decrease of the glucose sensing transcription factor MondoA in the nuclei.
An important contribution of MondoA to leukemia aggressiveness, which makes MondoA a potential candidate for targeted treatment of acute lymphoblastic leukemia.
the MondoA-TXNIP (zeige TXNIP Proteine) regulatory circuit has a role in the hexose transport curb, although other redundant pathways also contribute
Induction of TXNIP (zeige TXNIP Proteine) under lactic acidosis is caused by the activation of the glucose-sensing helix-loop-helix transcriptional complex MondoA:Mlx, which is usually triggered upon glucose exposure.
Glucose is required at two additional steps to stimulate the transcription activation function of MondoA-Mlx (zeige MLX Proteine) complexes.
MondoA is a basic helix-loop-helix/leucine zipper transcription factor (zeige NRL Proteine) that is expressed predominantly in skeletal muscle. Mice deficient for MondoA excel in sprinting, as their skeletal muscles display an enhanced glycolytic capacity.
MondoA-Mlx (zeige MLX Proteine) complexes sense elevated levels of G6P and adenine nucleotides to trigger a TXNIP (zeige TXNIP Proteine)-dependent feedback inhibition of glycolysis
MONDOA forms heterodimers with MLX (MIM 602976) that can bind to and activate transcription from CACGTG E boxes (Billin et al., 2000
MLX interacting protein
, MLX-interacting protein-like
, MLX-interacting protein
, Mlx interactor
, class E basic helix-loop-helix protein 36
, transcriptional activator MondoA