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The product of MLX belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. Zusätzlich bieten wir Ihnen MAX-Like Protein X Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal MLX Primary Antibody für EIA, WB - ABIN453747
Meroni, Cairo, Merla, Messali, Brent, Ballabio, Reymond: Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? in Oncogene 2000
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Human Polyclonal MLX Primary Antibody für ELISA, IHC - ABIN4334896
Stoltzman, Peterson, Breen, Muoio, Billin, Ayer: Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. in Proceedings of the National Academy of Sciences of the United States of America 2008
MLX promotes myogenesis not via an adjustment of glucose metabolism but rather by inducing the expression of several myokines, including insulin-like growth factor 2 (IGF2 (zeige IGF2 Antikörper))
Glucose is required at two additional steps to stimulate the transcription activation function of MondoA (zeige MLXIP Antikörper)-Mlx complexes.
Overexpression of dominant negative Mlx improves glucose intolerance by inhibiting expression not only of lipogenic enzymes but also other important genes such as Glucose-6-phosphatase (zeige G6PC Antikörper) and Elovl6 (zeige ELOVL6 Antikörper).
MYC (zeige MYC Antikörper) is part of a network of bHLHLZ proteins centered on the MYC (zeige MYC Antikörper) heterodimeric partner MAX and its counterpart, the MAX-like protein MLX.
Knockdown of MondoA (zeige MLXIP Antikörper), or its dimerization partner Mlx, blocks Myc (zeige MYC Antikörper)-induced reprogramming of multiple metabolic pathways, resulting in apoptosis
Data show that for both MondoA (zeige MLXIP Antikörper) and Mlx, the C-terminal domain CRM-1 (zeige XPO1 Antikörper) has cytoplasmic localization activity that is required by the protein monomers to accumulate in the cytoplasm.
Mlx is an obligatory partner of ChREBP (zeige MLXIPL Antikörper) in regulating lipogenic enzyme genes in liver.
Endogenous MondoA (zeige MLXIP Antikörper) and Mlx associate with mitochondria in primary skeletal muscle.
The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
MAX-like protein X
, transcription factor-like protein 4
, max-like protein X
, BigMax alpha
, MAX-like bHLHZIP protein
, protein BigMax
, transcription factor like 4
, transcription factor-like 4
, transcription factor max-like protein X
, BigMax protein
, class D basic helix-loop-helix protein 13
, max-like factor protein