MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) Proteine (MAD2L1)

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Zusätzlich bieten wir Ihnen MAD2L1 Antikörper (122) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MAD2L1 56150 Q9Z1B5
MAD2L1 4085 Q13257
Ratte MAD2L1 MAD2L1 297176  
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Showing 8 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Human His tag Human MAD2L1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
388,57 €
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
525,00 €
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Anmelden zum Anzeigen 11 bis 15 Tage
303,81 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_Escherichia coli (E. coli) Human Unkonjugiert   10 μg Anmelden zum Anzeigen 6 bis 8 Tage
374,15 €
Details

MAD2L1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,
, ,

Am meisten referenzierte MAD2L1 Proteine

  1. Human MAD2L1 Protein expressed in Escherichia coli (E. coli) - ABIN2005328 : Mapelli, Massimiliano, Santaguida, Musacchio: The Mad2 conformational dimer: structure and implications for the spindle assembly checkpoint. in Cell 2007 (PubMed)
    Zeige alle 5 Referenzen für 2005328

  2. Human MAD2L1 Protein expressed in Escherichia coli (E. coli) - ABIN667562 : Habu, Kim, Weinstein, Matsumoto: Identification of a MAD2-binding protein, CMT2, and its role in mitosis. in The EMBO journal 2002 (PubMed)
    Zeige alle 2 Referenzen für 667562

  3. Human MAD2L1 Protein expressed in Escherichia coli (E. coli) - ABIN2181494 : Luo, Fang, Coldiron, Lin, Yu, Kirschner, Wagner: Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20. in Nature structural biology 2000 (PubMed)
    Zeige alle 2 Referenzen für 2181494

Weitere Proteine zu MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) Interaktionspartnern

Mouse (Murine) MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) Interaktionspartner

  1. reduced MAD2 (zeige MXI1 Proteine) levels attenuate the apoptotic response to mis (zeige AMH Proteine)-segregating sex chromosomes and allow the formation of aneuploid sperm.

  2. p31comet-induced cell death is mediated by interactions with Mad2 (zeige MXI1 Proteine)

  3. study shows that Mad2 (zeige MXI1 Proteine) is a novel substrate for CCP6 (zeige AGBL4 Proteine) in megakaryocytes; Mad2 (zeige MXI1 Proteine) polyglutamylation plays a crucial role in the regulation of megakaryopoiesis

  4. Exacerbating chromosome missegregation in CENP-E (zeige CENPE Proteine)+/- mice by reducing levels of another mitotic checkpoint component (zeige BUB3 Proteine), Mad2 (zeige MXI1 Proteine), results in elevated cell death and decreased tumor formation compared with reduction of either protein alone.

  5. Mad2 (zeige MXI1 Proteine) is also repressed by p53 (zeige TP53 Proteine) and its upregulation is required for chromosome instability in a p53 (zeige TP53 Proteine) mutant tumor model

  6. Data show that Mad2 (zeige MXI1 Proteine) haploinsufficiency is protective in the presence of a cycle-specific DNA synthesis agent in vivo, and Ape1/Ref-1 (zeige APEX1 Proteine) inhibitor in vitro.

  7. Pcid2 (zeige PCID2 Proteine) is essential for B cell survival through the regulation of MAD2 (zeige MXI1 Proteine) expression during B cell differentiation

  8. tumours that experience transient Mad2 (zeige MXI1 Proteine) overexpression and consequent chromosome instability recur at markedly elevated rates

  9. a functional Mad2 (zeige MXI1 Proteine)-dependent spindle checkpoint exists during the first meiotic division in mammalian oocytes

  10. Data show that the loss of Trrap leads to chromosome missegregation, mitotic exit failure and compromised mitotic checkpoints, which are caused by defective Trrap-mediated transcription of the mitotic checkpoint (zeige BUB3 Proteine) proteins Mad1 (zeige MXD1 Proteine) and Mad2 (zeige MXI1 Proteine).

Human MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) Interaktionspartner

  1. Thes authors show that p31 (zeige ATP6V1E1 Proteine)(comet) binding to the TRIP13 (zeige TRIP13 Proteine) N-terminal domain positions the disordered MAD2 N-terminus for engagement by the TRIP13 (zeige TRIP13 Proteine) "pore loops", which then unfold MAD2 in the presence of ATP.

  2. catalytic activation of the spindle assembly checkpoint depends on regulated protein-protein interactions that accelerate the spontaneous but rate-limiting conversion of MAD2 required for mitotic checkpoint (zeige BUB3 Proteine) complex assembly

  3. in addition to its role in checkpoint signaling, MAD2 ensures chromosome stability through the regulation of AURORA B (zeige AURKB Proteine).

  4. Aberrant Mad2 expression was associated with cell proliferation and genetic instability, which may contribute to the carcinogenesis of PGI (zeige BGN Proteine)-DLBCL. Mad2 overexpression indicated a poor DFS (zeige FST Proteine).

  5. interactions between Mad2 and H3K4 regulate resolution of the spindle assembly checkpoint by limiting closed Mad2 availability for Cdc20 (zeige CDC20 Proteine) inhibition.

  6. we showed that BubR1 (zeige BUB1B Proteine) and Mad2 are overexpressed in oral squamous cell carcinoma cell lines and linked such overexpression to attenuated spindle assembly checkpoint activity.

  7. Studied the folding/unfolding process of the open and closed conformers of human Mad2.

  8. MAD1L1 (zeige MAD1L1 Proteine) Arg558His and MAD2L1 Leu84Met interaction with smoking increase the risk of colorectal cancer

  9. p31comet-induced cell death is mediated by interactions with Mad2

  10. MAD2L1 and BUB1 (zeige BUB1 Proteine) may play important roles in breast cancer progression, and measuring the expression of these genes may assist the prediction of breast cancer prognosis.

MAD2L1 Protein Überblick

Protein Überblick

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.

Genbezeichner und Symbole assoziert mit MAD2L1

  • MAD2 mitotic arrest deficient-like 1 (yeast) (MAD2L1)
  • MAD2 mitotic arrest deficient-like 1 (yeast) (mad2l1)
  • MAD2 mitotic arrest deficient-like 1 (mad2l1)
  • MAD2 mitotic arrest deficient-like 1 (MAD2L1)
  • MAD2 mitotic arrest deficient-like 1 (yeast) (LOC100218172)
  • MAD2 mitotic arrest deficient-like 1 (Mad2l1)
  • MAD2 mitotic arrest deficient-like 1 (yeast) (Mad2l1)
  • AA673185 Protein
  • cb408 Protein
  • HSMAD2 Protein
  • MAD2 Protein
  • MAD2L1 Protein
  • XMad2 Protein
  • zgc:112133 Protein

Bezeichner auf Proteinebene für MAD2L1

MAD2-like 1 , mitotic spindle assembly checkpoint protein MAD2A , spindle assembly checkpoint protein Mad2 , MAD2 mitotic arrest deficient-like 1 (yeast) , MAD2 mitotic arrest deficient-like 1 , MAD2 (mitotic arrest deficient, homolog)-like 1 , MAD2-like protein 1 , mitotic arrest deficient 2-like protein 1 , MAD2 (mitotic arrest deficient, yeast, homolog)-like 1 , mitotic arrest deficient, yeast, homolog-like 1

GENE ID SPEZIES
461661 Pan troglodytes
550434 Danio rerio
708574 Macaca mulatta
787996 Bos taurus
100125170 Xenopus (Silurana) tropicalis
100137358 Papio anubis
100218172 Taeniopygia guttata
56150 Mus musculus
380433 Xenopus laevis
4085 Homo sapiens
422675 Gallus gallus
476070 Canis lupus familiaris
337870 Bos taurus
297176 Rattus norvegicus
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