anti-MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) (MAD2L2) Antikörper

The protein encoded by MAD2L2 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Zusätzlich bieten wir Ihnen MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MAD2L2 71890 Q9D752
MAD2L2 10459 Q9UI95
MAD2L2 313702 D3Z8D9
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Top anti-MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) Antikörper auf antikoerper-online.de

Showing 10 out of 46 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Hund Maus Unkonjugiert IF, WB Western blot analysis of MAD2B on a K-562 cell lysate (Human bone marrow myelogenous leukemia, ATCC CCL-243). Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the mouse anti- MAD2B antibody. Immunofluorescence staining of human endothelial cells. 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
$168.74
Details
Human Kaninchen Unkonjugiert EIA, IF, IHC (p), WB 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
$368.50
Details
Human Kaninchen Unkonjugiert CP, IHC, ELISA, WB Affinity Purified anti-MAD2L2 antibody shows strong nuclear and cytoplasmic staining of tumor cells in cancerous human kidney tissue. Tissue was formalin-fixed and paraffin embedded. Brown color indicates presence of protein, blue color shows cell nuclei. 100 μg Anmelden zum Anzeigen 1 bis 2 Tage
$389.00
Details
Human Kaninchen Unkonjugiert IF, IHC (p), ELISA, WB Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with MAD2L2 antibody ABIN214364 at 10 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$451.00
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of extracts of various cells, using MAD2L2 antibody. 100 μL Anmelden zum Anzeigen 16 Days
$334.02
Details
Human Kaninchen Unkonjugiert IF, IHC, ELISA, WB 0.05 mg Anmelden zum Anzeigen 2 bis 3 Tage
$550.00
Details
Human Kaninchen Unkonjugiert ELISA, ICC, IF, IHC, IHC (p), WB Western Blot: MAD2L2 Antibody [NBP1-02798] - Affinity Purified Rabbit anti-MAD2L2 was used at a 1:500 dilution to detect human MAD2L2 by western blot. Both HeLa whole cell lysate (lane 1) and nuclear lysate (lane 2) were probed using this antibody. This antibody clearly detects a ~20 kD band corresponding to human MAD2L2 (predicted molecular weight is 24 kD). Approximately 20 ug of each lysate was loaded on a 10% SDS-PAGE. Primary antibody was reacted with the membrane at room temperature for 1 h. After subsequent washing, a 1:2000 dilution of HRP conjugated Gt-a-Rabbit IgG was used for visualization. Exposure time was 30 sec. Immunohistochemistry-Paraffin: MAD2L2 Antibody [NBP1-02798] - Staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 0.05 mg Anmelden zum Anzeigen 10 bis 13 Tage
$556.31
Details
Human Kaninchen HRP IHC (p), WB   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
Details
Human Kaninchen Alexa Fluor 488 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
Details
Human Kaninchen Alexa Fluor 555 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
Details

MAD2L2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) Antikörper

  1. Dog (Canine) Monoclonal MAD2L2 Primary Antibody für IF, WB - ABIN968795 : Chen, Fang: MAD2B is an inhibitor of the anaphase-promoting complex. in Genes & development 2001 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) Interaktionspartner

Mouse (Murine) MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) (MAD2L2) Interaktionspartner

  1. Skp2, a confirmed APC (zeige APC Antikörper)/C-CDH1 (zeige CDH1 Antikörper) substrate and E-cadherin (zeige CDH1 Antikörper) destroyer, was increased in TGF-beta1 (zeige TGFB1 Antikörper)-treated proximal tubular epithelial cells, which could be blocked by MAD2B depletion.

  2. This study demonstrates using super-resolution microscopy that numerous MAD2L2 microfoci are exclusively associated with euchromatin, similar to other factors of the DNA damage response. In the absence of MAD2L2 the amount of heterochromatin demarcated by H3K9me2 was significantly increased.

  3. Increased gonadotropins caused by the absence of functional oocytes and accumulation of DNA damage in cells caused by the lack of repair function could be responsible for the development and progression of ovarian tumors in the Rev7 mutant mouse.

  4. the Mad2l2 (MAD2B, Rev7) gene product is not only required by PGCs, but also by pluripotent embryonic stem cells (ESCs (zeige NR2E3 Antikörper)), depending on the growth conditions.

  5. results reveal an unexpected crucial function of REV7 downstream of 53BP1 in coordinating pathological DSB repair pathway choices in BRCA1-deficient cells

  6. that MAD2B may play an important role in high glucose-mediated podocyte injury of diabetic nephropathy via modulation of Cdh1, cyclin B1, and Skp2 expression

  7. These results demonstrated that Rev7 is essential in resolving the replication stalls caused by DNA damage during S phase.

  8. The function of Mad2l2 is essential in PGCs, and thus of high relevance for fertility

  9. Rev7 is essential for PGC (zeige PGC Antikörper) maintenance by prevention of apoptotic cell death in the mouse.

  10. identification of the Rev7 binding surface of the Rev1 C-terminal domain

Xenopus laevis MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) (MAD2L2) Interaktionspartner

  1. We have successfully isolated Xenopus laevis Mad2B and PRCC (zeige PRCC Antikörper) cDNAs, so the well-established animal model Xenopus laevis can be used as a powerful system to study in detail the role of xPRCC (zeige PRCC Antikörper) and xMad2B in the intricate processes of cell cycle control.

Human MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) (MAD2L2) Interaktionspartner

  1. Skp2, a confirmed APC (zeige APC Antikörper)/C-CDH1 (zeige CDH1 Antikörper) substrate and E-cadherin (zeige CDH1 Antikörper) destroyer, was increased in TGF-beta1 (zeige TGFB1 Antikörper)-treated proximal tubular epithelial cells, which could be blocked by MAD2B depletion.

  2. structure-based interaction analyses revealed an unprecedented mechanism involving CAMP's WK motif. Surprisingly, in one of the crystal forms, the MAD2L2-CAMP complex formed a dimeric structure in which the C-terminal region of MAD2L2 was swapped and adopted an immature structure

  3. REV7 is a previously undescribed FA gene, which we term FANCV

  4. Knockdown of REV7 inhibited the migration, invasion, and epithelial-mesenchymal transition (EMT (zeige ITK Antikörper)) of breast cancer cells. Meanwhile, overexpression of REV7 promoted the migration, invasion, and EMT (zeige ITK Antikörper) of breast cancer cells.

  5. hMAD2 also binds to the hREV7-binding sequence in hREV3 (zeige REV3L Antikörper), whereas hMAD2 does not bind to a similar sequence in ADAM9 (zeige ADAM9 Antikörper) or ELK-1 (zeige ELK1 Antikörper) and hREV7 does not bind to the hMAD2-binding sequence in hMAD1 or hCDC20.

  6. data establish MAD2L2 as a crucial contributor to the control of DNA repair activity by 53BP1 (zeige TP53BP1 Antikörper) that promotes NHEJ by inhibiting 5' end resection downstream of RIF1 (zeige INSL6 Antikörper)

  7. results reveal an unexpected crucial function of REV7 downstream of 53BP1 in coordinating pathological DSB repair pathway choices in BRCA1-deficient cells

  8. that MAD2B may play an important role in high glucose-mediated podocyte injury of diabetic nephropathy via modulation of Cdh1, cyclin B1, and Skp2 expression

  9. Rev7 is essential for mutagenesis and S phase progression in UV-irradiated fibroblasts.

  10. These findings indicate that depletion of REV7 enhances sensitivity to cisplatin treatment in ovarian clear cell carcinoma (CCC), suggesting that REV7 is a candidate molecular target in CCC management.

MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) (MAD2L2) Antigen-Profil

Protein Überblick

The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins.

Genbezeichner und Symbole assoziert mit MAD2L2

  • mitotic arrest deficient 2 like 2 (mad2l2) Antikörper
  • mitotic arrest deficient 2 like 2 (MAD2L2) Antikörper
  • MAD2 mitotic arrest deficient-like 2 (Mad2l2) Antikörper
  • mitotic arrest deficient 2 like 2 S homeolog (mad2l2.S) Antikörper
  • mitotic arrest deficient 2 like 2 (Mad2l2) Antikörper
  • MAD2 mitotic arrest deficient-like 2 (yeast) (MAD2L2) Antikörper
  • si:dkey-23c22.2 (si:dkey-23c22.2) Antikörper
  • 2310033C13Rik Antikörper
  • mad2B Antikörper
  • mad2l2 Antikörper
  • mad2l2-A Antikörper
  • POLZ2 Antikörper
  • REV7 Antikörper
  • xMAD2L2 Antikörper
  • zgc:110299 Antikörper

Bezeichner auf Proteinebene für MAD2L2

MAD2-like protein 2 , Mitotic arrest deficient 2-like protein 2 , mitotic spindle assembly checkpoint protein MAD2B , MAD2 homolog , mitotic arrest deficient 2-like protein 2 , Mitotic arrest defective protein 2B , MAD2 (mitotic arrest deficient, yeast, homolog)-like 2 , REV7 homolog , hREV7 , mitotic arrest deficient homolog-like 2 , polymerase (DNA-directed), zeta 2, accessory subunit

GENE ID SPEZIES
448122 Xenopus (Silurana) tropicalis
457953 Pan troglodytes
714527 Macaca mulatta
71890 Mus musculus
394380 Xenopus laevis
10459 Homo sapiens
313702 Rattus norvegicus
506605 Bos taurus
419493 Gallus gallus
487443 Canis lupus familiaris
550258 Danio rerio
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