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LOXL4 encodes a member of the lysyl oxidase gene family. Zusätzlich bieten wir Ihnen Lysyl Oxidase-Like 4 Kits (18) und Lysyl Oxidase-Like 4 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal LOXL4 Primary Antibody für ELISA, WB - ABIN566544
Sebban, Davidson, Reich: Lysyl oxidase-like 4 is alternatively spliced in an anatomic site-specific manner in tumors involving the serosal cavities. in Virchows Archiv : an international journal of pathology 2008
Show all 2 Pubmed References
These results demonstrate that weak LOXL4 expression leads to remodeling of the extracellular matrix through induction of collagen synthesis, deposition, and structural changes.
Although expression of LOXL4 is not statistically associated with neck metastases, we showed that LOXL4 expression significantly increased in laryngeal cancer.
In hepatocellular carcinoma, low LOXL4 expression was associated with lower overall survival rates and higher cumulative recurrence rates.
These results provide a set of the essential genes in this newly identified miR (zeige MLXIP Antikörper)-193a-3p/LOXL4/Oxidative Stress axis.
High Lysyl oxidase-like 4 promotes proliferation and metastasis of gastric cancer via FAK (zeige PTK2 Antikörper)/Src (zeige SRC Antikörper) pathway.
data suggest that abnormal expression of LOXL4 of KCOT may enhance angiogenesis in KCOT, which may help to promote the locally aggressive biological behavior of KCOT.
TGF-beta1 (zeige TGFB1 Antikörper) induced injured MCL (zeige FH Antikörper) to express more LOXs than injured ACL (zeige ACLY Antikörper) (up to 1.85-fold in LOX (zeige LOX Antikörper), 2.21-fold in LOXL-1 (zeige LOXL1 Antikörper), 1.71-fold in LOXL-2 (zeige LOXL2 Antikörper), 2.52-fold in LOXL-3 (zeige LOXL3 Antikörper) and 3.32-fold in LOXL-4).
Alternatively spliced lysyl oxidase-like 4 isoforms have a pro-metastatic role in cancer.
The human lysyl oxidase-like 4 gene does not confer increased genotypic risk for adolescent idiopathic scoliosis.
SNPs in the lysyl oxidase-like protein 4 and complement component 3 (zeige C3 Antikörper) genes are associated with increased risk for endometriosis and endometriosis-associated infertility in a Puerto Rican population.
Overexpression of the lysyl oxidase-like 4 gene is associated with metastatic head/neck carcinoma.
These results suggest that TGF-beta1 (zeige TGFB1 Antikörper)-dependent expression of LOXL4 plays a role in vascular extracellular matrix homeostasis, contributing to vascular processes associated with extracellular matrix remodeling and fibrosis.
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
lysyl oxidase-like 4
, lysyl oxidase related protein homolog-like
, lysyl oxidase homolog 4-like
, lysyl oxidase homolog 4
, lysyl oxidase-like protein 4
, lysyl oxidase-related protein C
, lysyl oxidase related C
, lysyl oxidase-like 4 pseudogene