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The protein encoded by LOX is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. Zusätzlich bieten wir Ihnen LOX Kits (41) und LOX Proteine (13) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 194 products:
Cow (Bovine) Polyclonal LOX Primary Antibody für ICC, IF - ABIN250966
Wilhelmus, Bol, van Duinen, Drukarch: Extracellular matrix modulator lysyl oxidase colocalizes with amyloid-beta pathology in Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis--Dutch type. in Experimental gerontology 2013
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Human Polyclonal LOX Primary Antibody für ICC, IHC (fro) - ABIN258622
Jeay, Pianetti, Kagan, Sonenshein: Lysyl oxidase inhibits ras-mediated transformation by preventing activation of NF-kappa B. in Molecular and cellular biology 2003
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Human Polyclonal LOX Primary Antibody für ICC, IF - ABIN258371
Palamakumbura, Jeay, Guo, Pischon, Sommer, Sonenshein, Trackman: The propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells. in The Journal of biological chemistry 2004
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Human Polyclonal LOX Primary Antibody für FACS, ICC - ABIN447477
Sato, Trackman, Mäki, Myllyharju, Kirsch, Sonenshein: The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells. in Molecular and cellular biology 2011
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Human Monoclonal LOX Primary Antibody für WB - ABIN1882262
Gao, Xiao, Ma, Li, Liu, Feng, Fang, Wu, Han, Zhang, Sun, Wu, Padera, Chen, Wong, Ge, Ji: LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling. in Proceedings of the National Academy of Sciences of the United States of America 2010
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Human Monoclonal LOX Primary Antibody für WB - ABIN1882261
Santhanam, Baker, Hegamyer, Kirschmann, Colburn: Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion. in Oncogene 2010
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Human Polyclonal LOX Primary Antibody für ICC, IF - ABIN440592
Di Stefano, Torsello, Bianchi, Cifola, Mangano, Bovo, Cassina, De Marco, Corti, Meregalli, Bombelli, Viganò, Battaglia, Strada, Perego: Major Action of Endogenous Lysyl Oxidase in Clear Cell Renal Cell Carcinoma Progression and Collagen Stiffness Revealed by Primary Cell Cultures. in The American journal of pathology 2016
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Human Polyclonal LOX Primary Antibody für EIA, FACS - ABIN953265
Mariani, Trackman, Kagan, Eddy, Shows, Boyd, Deak: The complete derived amino acid sequence of human lysyl oxidase and assignment of the gene to chromosome 5 (extensive sequence homology with the murine ras recision gene). in Matrix (Stuttgart, Germany) 1992
Human Polyclonal LOX Primary Antibody für ICC, IF - ABIN4331347
Contente, Yeh, Friedman: Tumor suppressive effect of lysyl oxidase proenzyme. in Biochimica et biophysica acta 2009
Partial knockdown of lysyl oxidase genes sensitizes the developing embryo to dithiocarbamate exposure.
Data reveal a role for lysyl oxidase in early morphogenesis, especially in muscle development and neurogenesis, and resume some aspects of physiopathology of copper metabolism.
LOX, a hypoxia-responsive gene that encodes lysyl oxidase, is activated by HIF-2-alpha (zeige EPAS1 Antikörper) more than HIF-1 (zeige HIF1A Antikörper). Two new hypoxia response elements identified in the LOX promoter mediate most HIF responsiveness.
our findings show that LOX supports colorectal cancer cell dissemination in the bone marrow
LOX G473A polymorphism apparently elevated human sensitivity to cigarette smoking carcinogens for eliciting cancers in the lung and colon only. Thus, LOX G473A polymorphism positively correlates with carcinogenesis and it may be used as an ideal intrinsic biomarker for prediction or diagnosis of carcinogenesis in humans.
increased cortisol and 11beta-HSD1 (zeige HSD11B1 Antikörper) abundance and decreased LOX abundance were observed in human amnion tissue after the labor-initiated spontaneous rupture of membranes
endogenous LOX is overexpressed in clear cell renal cell carcinoma (zeige MOK Antikörper), is involved in a positive-regulative loop with HIF-1alpha (zeige HIF1A Antikörper), and has a major action on clear cell renal cell carcinoma (zeige MOK Antikörper) progression through cellular adhesion, migration, and collagen matrix stiffness increment
colorectal carcinoma perilesional extracellular matrix has increased content of lysyl oxidase
LOX affects the epithelial-mesenchymal transition of gastric cancer cells in hypoxic conditions.
High expression of LOX is associated with nasopharyngeal carcinoma.
Here we show that orthotopic implantation of rat prostate AT-1 tumour cells increased LOX and LOXLs mRNA expressions in the tumour and in the surrounding non-malignant prostate tissue
Results show that LOX expression regulation by FoxF1 (zeige FOXF1 Antikörper) increases invasiveness of breast cancer cells.
Statins normalize vascular lysyl oxidase (LOX) down-regulation induced by proatherogenic risk factors.
These results indicate that proLOX could be processed by two different mechanisms producing two forms of active LOX.
Lysyl oxidase enhances elastin (zeige ELN Antikörper) synthesis and matrix formation by vascular smooth muscle cells
Lysyl oxidase has a role in oxidizing basic fibroblast growth factor (zeige FGF2 Antikörper) and inactivating its mitogenic potential
In cases of vascular calcification, the decreased expression of LOX may be partially responsible for decreased vascular elasticity and also for the decreased formation of new elastic fibers.
Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors.
LOX targeting reduces peritoneal fibrosis.
Absence of lysyl oxidase (Lox) causes thoracic aortic aneurysms. The aortic mechanical behavior of Lox(-/-) mice is consistent with reduced elastin (zeige ELN Antikörper) and collagen cross-linking but demonstrates vascular location-specific differences. Lox(-/-) aortas show upregulation of matrix remodeling genes and location-specific differential expression of other matrix and smooth muscle cell gene sets.
Findings from this study indicate that preventing LOX overexpression may be protective against high glucose-induced apoptosis in retinal vascular cells associated with diabetic retinopathy.
LOX family members contribute significantly to the detrimental effects of cardiac remodelling, highlighting LOX inhibition as a potential therapeutic strategy for post-infarction recovery
Findings suggest that the lysyl oxidase (LOX)-mediated organization of collagen fibers in the extracellular matrix is an important regulator of osteoblastogenesis.
The data suggest a fibromodulin (zeige FMOD Antikörper)-modulated collagen cross-linking mechanism where fibromodulin (zeige FMOD Antikörper) binds to a specific part of the collagen domain and also forms a complex with lysyl oxidase, targeting the enzyme toward specific cross-linking sites.
Data suggest of pharmacologic targeting of lysyl oxidase (LOX) pathway to inhibit liver fibrosis and promote its resolution.
Cu chaperone function of Atox1 (zeige ATOX1 Antikörper) mediated through Cu transporter ATP7A (zeige ATP7A Antikörper) is required for VEGF (zeige VEGFA Antikörper)-induced angiogenesis via activation of Cu enzyme lysyl oxidase.
CTR1 (zeige SLC31A1 Antikörper), ATP7A (zeige ATP7A Antikörper), and lysyl oxidase were upregulated in the lung tissues and pulmonary arteries of mice with hypoxia-induced pulmonary hypertension and pulmonary arterial smooth muscle cells.
Inhibition of tissue transglutaminase (zeige TGM2 Antikörper) resulted in a reduced rate of compaction compared to controls during early remodeling (up to 2 days). In contrast, inhibition of lysyl oxidase did not alter the early compaction.
The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.
, protein-lysine 6-oxidase-like
, protein-lysine 6-oxidase
, ras excision protein
, ras recision gene (rrg)
, Lysyl oxidase (an H-rev gene with its expression down-regulated in HRAS-transformed rat 208F fibroblasts)