anti-Lysine (K)-Specific Demethylase 5C (KDM5C) Antikörper

KDM5C is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. Zusätzlich bieten wir Ihnen KDM5C Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
KDM5C 8242 P41229
KDM5C 20591 P41230
KDM5C    
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Showing 10 out of 53 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IP, WB Western Blot and Immunoprecipitation: JARID1C Antibody [ABIN188638] - Detection of Human JARID1C by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-JARID1C antibody ABIN188638 used for WB at 0.04 mcg/ml (A) and 0.1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. JARID1C was also immunoprecipitated by rabbit anti-JARID1C antibody ABIN188637, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 30 seconds (A and B). 0.1 mL Anmelden zum Anzeigen 2 bis 4 Tage
371,00 €
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Rind (Kuh) Maus Unkonjugiert ICC, IF, IHC (p), WB Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Anmelden zum Anzeigen 11 bis 14 Tage
501,70 €
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Human Kaninchen Unkonjugiert ELISA, WB 50 μL Anmelden zum Anzeigen 6 bis 8 Tage
267,72 €
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Human Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
600,64 €
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Human Maus Unkonjugiert ICC, WB   100 μL Anmelden zum Anzeigen 10 bis 13 Tage
190,48 €
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Human Kaninchen Unkonjugiert WB Western Blot: SMCX Antibody [NBP2-20422] - Sample (30 ug of whole cell lysate) A: IMR32 5% SDS PAGE gel, diluted at 1:10000. 0.1 mL Anmelden zum Anzeigen 3 bis 6 Tage
341,00 €
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Human Maus Unkonjugiert ICC, WB Western blot analysis of extracts of various cells, using JARID1C antibody. 100 μL Anmelden zum Anzeigen 12 Days
327,38 €
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Human Kaninchen Unkonjugiert IP, WB Western Blot and Immunoprecipitation: JARID1C Antibody [ABIN188637] - Detection of Human JARID1C by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-JARID1C antibody ABIN188637 used for WB at 0.04 mcg/ml (A) and 0.1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. JARID1C was also immunoprecipitated by rabbit anti-JARID1C antibody ABIN188638, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A and B). Western Blot: SMCX Antibody  - Detection of Human and Mouse Jarid1C by Western Blot. Samples: Whole cell lysate (50, 15 ug) from HeLa and (50 ug) from 293T, Jurkat, and mouse NIH3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-Jarid1C antibody  used for WB at 0.04 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 0.1 mL Anmelden zum Anzeigen 2 bis 4 Tage
371,00 €
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Human Kaninchen Unkonjugiert WB   50 μL Anmelden zum Anzeigen 11 bis 14 Tage
548,26 €
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Human Kaninchen Unkonjugiert ChIP, WB .JARID1C / KDM5C pAb tested by ChIP. Chromatin immunoprecipitation (ChIP) was performed using the ChIP-IT® High Sensitivity Kit (Cat. No. 53040) with 30 µg of chromatin from human MIA PaCa-2 pancreatic carcinoma cells and 10 µl JARID1C / KDM5C antibody. ChIP DNA was used in qPCR with the control primer pairs or gene-specific primer pairs as indicated. Data are presented as Binding Events Detected per 1000 Cells using Active Motif's Epigenetic Services normalization scheme which accounts for primer efficiency and the amount of chromatin used in the ChIP reaction. JARID1C / KDM5C pAb tested by Western blot. Nuclear extract of HeLa cells (20 µg) probed with JARID1C / KDM5C pAb (1:1,000) 200 μL Anmelden zum Anzeigen 1 bis 3 Tage
497,22 €
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KDM5C Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-KDM5C Antikörper

  1. Human Polyclonal KDM5C Primary Antibody für IP, WB - ABIN188638 : Smith, Haberstroh, White, Livingston, DeCaprio, Howley: SMCX and components of the TIP60 complex contribute to E2 regulation of the HPV E6/E7 promoter. in Virology 2014 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal KDM5C Primary Antibody für ChIP, WB - ABIN2668493 : Nishibuchi, Shibata, Hayakawa, Hayakawa, Ohtani, Sinmyozu, Tagami, Nakayama: Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex. in The Journal of biological chemistry 2014 (PubMed)

Weitere Antikörper gegen KDM5C Interaktionspartner

Human Lysine (K)-Specific Demethylase 5C (KDM5C) Interaktionspartner

  1. KDM5C expression was generally lower in cancer lesions compared with matched nontumor tissues. KDM5C has a vital function in inhibiting cell mobility, which is at least partially controlled by the p53 (zeige TP53 Antikörper).

  2. Mutation in KDM5C gene is associated with cancer more frequently in males.

  3. In vitro models indicated that KDM5C suppressed miR (zeige MLXIP Antikörper)-320a transcription by directly binding to the promoter of miR (zeige MLXIP Antikörper)-320a to prevent histone methylation. KITLG (zeige KITLG Antikörper), an essential gene for ovarian development and primordial germ cell survival, was a direct target of miR (zeige MLXIP Antikörper)-320a and that it was downregulated in 45,X fetal gonadal tissues.

  4. The two mutations are present on the same maternal haplotype, suggesting that a postzygotic somatic mutation or a reversion error occurred at an early embryonic stage in the mother, leading to switched KDM5C mutations in the affected siblings.

  5. The predicted structure of KDM5C was used to investigate the effects of disease-causing mutations, and it was shown that the mutations alter domain stability and inter-domain interactions.

  6. Results suggest that KDM5C mutations predispose to X-linked intellectual disability which accounts for 1-4% of cases in male patient.

  7. the extent of the duplicated regions in each case encompassing a minimum of three known disease genes TSPYL2 (zeige TSPYL2 Antikörper), KDM5C and IQSEC2 (zeige IQSEC2 Antikörper), is reported.

  8. KDM5C is overexpressed in breast cancer cells and miR (zeige MLXIP Antikörper)-138 regulates its expression.

  9. study of non-synonymous mutations in the KDM5C ARID domain and evaluates effects of 2 syndromic Claes-Jensen-type disease-associated missense mutations (A77T and D87G) and 3 non-classified missense mutations (R108W, N142S, and R179H); analysis indicates, among the non-classified mutations, R108W is possibly a disease-associated mutation, and N142S and R179H are probably harmless

  10. Findings reveal a RACK7 (zeige ZMYND8 Antikörper)/KDM5C-regulated, dynamic interchange between histone H3K4me1 and H3K4me3 at active enhancers, representing an additional layer of regulation of enhancer activity. Authors propose that RACK7 (zeige ZMYND8 Antikörper)/KDM5C functions as an enhancer "brake" to ensure appropriate enhancer activity, which, when compromised, could contribute to tumorigenesis.

Mouse (Murine) Lysine (K)-Specific Demethylase 5C (KDM5C) Interaktionspartner

  1. The results identify two key regulators, PCGF6 (zeige PCGF6 Antikörper) and JARID1c that temper dendritic cells (DC) activation and implicate active transcriptional silencing via histone demethylation as a previously unappreciated mechanism for regulating DC activation and quiescence.

  2. Neurite growth in Neuro2a cells was suppressed by the KDM5C mutations associated with intellectual disability in patients. Ntng2 (zeige NTNG2 Antikörper) was downregulated in cells with KDM5C mutations, concordant with the lower levels of H3K4 methylation at its promoter.

  3. these data suggest that inactivation of JARID1C in renal cancer leads to heterochromatin disruption, genomic rearrangement, and aggressive ccRCCs.

  4. The present study was designed to detect the expression of Histone H3 (zeige HIST3H3 Antikörper) lysine 4 methylation and its demethylases LSD1 (zeige KDM1A Antikörper), RBP2 (zeige RBP2 Antikörper) and SMCX in 21-, 40- and 60-day-old mouse testes.

  5. Kdm5c protein restricts transcriptional output at promoters, whereas Kdm5c binding to enhancers stimulates their activity.

  6. sex-specific expression of Jarid1c may contribute to sex differences in brain function

  7. allelic expression and RNA/DNA FISH indicate that transgenic Jarid1c escapes X inactivation.

Pig (Porcine) Lysine (K)-Specific Demethylase 5C (KDM5C) Interaktionspartner

  1. The full-length cDNA of JARID1C has been cloned.

KDM5C Antigen-Profil

Protein Überblick

This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit KDM5C

  • histone demethylase JARID1C (MGYG_04221) Antikörper
  • lysine (K)-specific demethylase 5C (KDM5C) Antikörper
  • lysine (K)-specific demethylase 5C (kdm5c) Antikörper
  • lysine (K)-specific demethylase 5C (Kdm5c) Antikörper
  • DXS1272E Antikörper
  • Jarid1c Antikörper
  • mKIAA0234 Antikörper
  • MRXJ Antikörper
  • MRXSCJ Antikörper
  • MRXSJ Antikörper
  • Smcx Antikörper
  • XE169 Antikörper

Bezeichner auf Proteinebene für KDM5C

histone demethylase JARID1C , lysine (K)-specific demethylase 5C , jumonji, AT rich interactive domain 1C , JmjC domain-containing protein SMCX , Jumonji, AT rich interactive domain 1C (RBP2-like) , Jumonji/ARID domain-containing protein 1C , Smcx homolog, X chromosome , Smcy homolog, X-linked , lysine-specific demethylase 5C , protein SmcX , selected cDNA on X , jumonji, AT rich interactive domain 1C (Rbp2 like) , jumonji/ARID domain-containing protein 1C , selected mouse cDNA on the X , lysine (K)-specific demethylase 5C tv1 , Lysine-specific demethylase 5C

GENE ID SPEZIES
10029336 Arthroderma gypseum CBS 118893
100075501 Ornithorhynchus anatinus
100341721 Oryctolagus cuniculus
100565551 Anolis carolinensis
8242 Homo sapiens
20591 Mus musculus
491894 Canis lupus familiaris
100037295 Sus scrofa
281490 Bos taurus
100758549 Cricetulus griseus
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