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LSP1 encodes an intracellular F-actin binding protein. Zusätzlich bieten wir Ihnen LSP1 Proteine (7) und LSP1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal LSP1 Primary Antibody für IF, IP - ABIN968145
Howard, Li, Torres, Guerrero, Coates: The 47-kD protein increased in neutrophil actin dysfunction with 47- and 89-kD protein abnormalities is lymphocyte-specific protein. in Blood 1994
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Human Polyclonal LSP1 Primary Antibody für WB - ABIN2801907
Jongstra-Bilen, Young, Chong, Jongstra: Human and mouse LSP1 genes code for highly conserved phosphoproteins. in Journal of immunology (Baltimore, Md. : 1950) 1990
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Human Polyclonal LSP1 Primary Antibody für ELISA, WB - ABIN4331781
Gringhuis, den Dunnen, Litjens, van der Vlist, Geijtenbeek: Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori. in Nature immunology 2009
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Human Polyclonal LSP1 Primary Antibody für ELISA, WB - ABIN4331782
Liu, Cara, Kaur, Raharjo, Mullaly, Jongstra-Bilen, Jongstra, Kubes: LSP1 is an endothelial gatekeeper of leukocyte transendothelial migration. in The Journal of experimental medicine 2005
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Human Polyclonal LSP1 Primary Antibody für IHC, IHC (p) - ABIN4331785
Johansson, Tabor, Wikell, Jalkanen, Fuxe: TGF-β1-Induced Epithelial-Mesenchymal Transition Promotes Monocyte/Macrophage Properties in Breast Cancer Cells. in Frontiers in oncology 2015
the LSP1-myosin1e bimolecular complex plays a pivotal role in the regulation of actin cytoskeleton remodeling during Fc gamma receptor (zeige FCGR1A Antikörper)-driven phagocytosis.
the importance of LSP1 Copy number variations and LSP1 insufficiency in the pathogenesis of rheumatoid arthritis, is reported.
Data indicate that in lymphocyte specific 1 protein (LSP1)-deficient mice, PECAM-1 (zeige PECAM1 Antikörper) expression was reduced in endothelial cells, but not in neutrophils.
TRAF1 (zeige TRAF1 Antikörper) and LSP1 cooperate downstream of 4-1BB (zeige TNFRSF9 Antikörper) to activate ERK (zeige EPHB2 Antikörper) signaling and down-modulate the levels of Bim (zeige BCL2L11 Antikörper) leading to enhanced T cell survival.
Endothelial LSP1 participates in leukocyte adhesion in vitro, and leukocyte adhesion, through ICAM-1 (zeige ICAM1 Antikörper), fosters the activation of endothelial LSP1.
LSP1 plays an important role in leukocyte recruitment induced by both KC and MIP-2 (zeige CXCL2 Antikörper).
Data demonstrate that endothelial LSP1 is recruited to the cytoskeleton in inflammation and plays an important role in forming endothelial domes thereby regulating neutrophil transendothelial migration.
Lsp1 negatively regulates fMLP (zeige FPR1 Antikörper)-induced polarization and chemotaxis of neutrophils during inflammation through its function on adhesion via specific integrins, such as Mac-1 (CD11b/CD18 (zeige ITGAM Antikörper)).
The results show a complex function of LSP1 in regulating leukocyte recruitment to inflamed sites.
MK2-regulated LSP1 phosphorylation is involved in stabilization of F-actin polarization during neutrophil chemotaxis.
Underexpression of LSP1 is associated with Breast Cancer Recurrence.
LSP1 rs569550 and rs592373 polymorphisms are both risk factors for breast cancer.
The breast cancer SNP LSP1 rs3817198 was associated with an increased risk of lung cancer (odds ratio: 1.10) This association was strongest for women with adenocarcinoma (P = 1.2x10(-4)).
Data indicate that slit2N alters the localization and binding of Robo1 (zeige ROBO1 Antikörper) to WASp and LSP1 in HIV-1-gp120 (zeige ITIH4 Antikörper)-treated immature dendritic cells (iDCs).
Single nucleotide polymorphism in LSP1 is associated with breast cancer.
The LSP1 rs3817198T>C polymorphism is a low-penetrant risk factor for developing breast cancer but may not be in Africans.
Low-risk variants of LSP1 is associated with familial breast cancer.
The LSP1 and 2q35 SNPs appear to interact multiplicatively on breast cancer risk for BRCA2 (zeige BRCA2 Antikörper) mutation carriers.
LSP1 interacts with F-actin and the cytoskeleton through residues downstream of amino acid residue 230. The cytoskeleton binding site of mouse LSP1 maps to the 300-330 interval.
This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms.
lymphocyte-specific protein 1
, lymphocyte-specific protein 1, isoform 3
, 52 kDa phosphoprotein
, S37 protein
, leukocyte specific protein 1
, leukocyte-specific protein 1
, lymphocyte-specific antigen WP34
, 47 kDa actin binding protein
, 47 kDa actin-binding protein
, F-actin binding and cytoskeleton associated protein
, leufactin (leukocyte F-actin binding protein)
, 1 BAC CH230-300K22 (Children's Hospital Oakland Research Institute) complete
, lymphocyte specific 1