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LONP1 encodes a mitochondrial matrix protein in the Lon family of ATP-dependent proteases. Zusätzlich bieten wir Ihnen Lon Peptidase 1, Mitochondrial Antikörper (74) und Lon Peptidase 1, Mitochondrial Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
LONP1 function and implication in human aging and disease was reviewed.
we observed that Lon protease downregulation is linked to a higher lipofuscinogenesis whereas the application of the mitochondrial-targeted antioxidant mitoTEMPO is able to prevent the accumulation of this protein aggregate.
Lon preferentially degrades the phosphorylated subunits of CcO (zeige RYR1 ELISA Kits) and plays a role in the regulation of CcO (zeige RYR1 ELISA Kits) activity in hypoxia and ischemia/reperfusion injury.
Lon protease (Lonp1), which is a key inductive of mitochondrial unfolded protein response (UPR(mt)) and is required to maintain the mitochondrial quality, was greatly induced in H. pylori infected gastric epithelial cells.
Mutations of Lon, which likely impair its chaperone properties, are at the basis of a genetic inherited disease named the cerebral, ocular, dental, auricular, skeletal (CODAS) syndrome. (Review)
Inhibition of Lon protease by triterpenoids alters mitochondria and is associated to cell death in human cancer cells.
Lon downregulation attenuated hypoxia-induced cardiomyocyte apoptosis through a reduction of reactive oxygen species level.
LONP1 encodes an enzyme of bacterial ancestry that participates in protein turnover within the mitochondrial matrix, and mutations in its ATP-binding and proteolytic domains cause CODAS syndrome.
A review on the recent discoveries concerning Lon Protease functions. [review]
These results suggest that the mechanism underlying cell survival regulated by Lon is mediated by the maintenance of the protein stability of Hsp60 (zeige HSPD1 ELISA Kits)-mtHsp70 (zeige HSPA9 ELISA Kits) complex.
LONP1 knockdown inhibits cellular proliferation and tumor and metastasis formation, whereas its overexpression increases tumorigenesis.
Epidermal growth factor (zeige EGF ELISA Kits) up-regulates the transcription of ATP-dependent protease through extracellular signal-regulated protein kinase (zeige CDK7 ELISA Kits)- and 1-phosphatidylinositol 3-kinase (zeige PIK3CG ELISA Kits)-dependent pathways.
Modulation of Lon protease activity during aging and oxidative stress.
The correlative effect of Lon and ClpP (zeige CLPP ELISA Kits) upregulation on loss of mitochondrial Fe-S proteins during the progression of the disease may suggest that Fe-S proteins are potential targets of Lon and ClpP (zeige CLPP ELISA Kits) proteases in FRDA (zeige FXN ELISA Kits).
This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene.
lon peptidase 1, mitochondrial
, protease, serine, 15
, lon protease homolog, mitochondrial-like
, hLON ATP-dependent protease
, lon protease homolog, mitochondrial
, mitochondrial ATP-dependent protease Lon
, mitochondrial lon protease-like protein
, serine protease 15
, lon protease-like protein
, ATP-dependent Lon protease
, hypothetical protein