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Humans lipodystrophy is characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Zusätzlich bieten wir Ihnen LPIN3 Antikörper (43) und LPIN3 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
Association analysis showed that different genotypes of LPIN2 (zeige LPIN2 ELISA Kits) were associated with back-fat thickness between the 6th and 7th ribs (P < 0.01).
a newly identified novel cell-penetrating sequence (LPIN; RRKRRRRRK) from the nuclear localization sequence (NLS (zeige ALDH1A2 ELISA Kits)) of human nuclear phosphatase, LPIN3.
LPIN1 (zeige LPIN1 ELISA Kits)-related myolysis constitutes a major cause of early-onset rhabdomyolysis and occasionally in adults. Heterozygous LPIN1 (zeige LPIN1 ELISA Kits) mutations may cause mild muscular symptoms. No major defects of LPIN2 (zeige LPIN2 ELISA Kits) or LPIN3 genes were associated with muscle manifestations.
Data revealed that lipin 1 (zeige LPIN1 ELISA Kits) formed stable homo-oligomers with itself and hetero-oligomers with lipin 2 (zeige LPIN2 ELISA Kits)/3.
Lipin-3 exhibits phosphatidate phosphatase type-1 (PAP1) activity, which has a key role in glycerolipid synthesis.
Humans lipodystrophy is characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mice carrying mutations in the fatty liver dystrophy (fld) gene have similar phenotypes. Through positional cloning, the mouse gene responsible for fatty liver dystrophy was isolated and designated Lpin1. The nuclear protein encoded by Lpin1 was named lipin. Lpin1 mRNA was expressed at high levels in adipose tissue and was induced during differentiation of preadipocytes. These results indicated that lipin is required for normal adipose tissue development and provided a candidate gene for human lipodystrophy. Through database searches, mouse and human EST and genomic sequences with similarities to Lpin1 were identified. These included two related mouse genes (Lpin2 and Lpin3) and three human homologs (LPIN1, LPIN2, and LPIN3). Human LPIN1 gene has been mapped to 2p25.\; linkages of fat mass and serum leptin levels to this same region have been noted. Human LPIN2 and LPIN3 mapped to chromosomes 18p11 and 20q11-q12, respectively. The mouse genes encoding Lpin1, Lpin2, and Lpin3 mapped to chromosome 12, 17, and 2, respectively.
, phosphatidate phosphatase LPIN3
, phosphatidate phosphatase LPIN3-like