Like-Glycosyltransferase (LARGE) ELISA Kits

LARGE, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. Zusätzlich bieten wir Ihnen Like-Glycosyltransferase Antikörper (40) und Like-Glycosyltransferase Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
LARGE 9215 O95461
LARGE 16795 Q9Z1M7
Anti-Ratte LARGE LARGE 361368  
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Human
96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
788,70 €
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Maus
96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
788,70 €
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Huhn
96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
1.013,20 €
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Weitere ELISA Kits für Like-Glycosyltransferase Interaktionspartner

Human Like-Glycosyltransferase (LARGE) Interaktionspartner

  1. This study suggests LARGE as the first known modifier of plasma antithrombin (zeige SERPINC1 ELISA Kits).

  2. results reveal that the LARGE-glycan of dystroglycan serves as a tunable extra (zeige DAG1 PLURAL_@3194@)cellular matrix protein scaffold, the extension of which is required for normal skeletal muscle function

  3. LARGE could act as a bifunctional glycosyltransferase, with xylosyltransferase and glucuronyltransferase activities, which produced repeating units of [-3-xylose-alpha1,3-glucuronic acid-beta1-]; allowed alpha-DG to bind laminin-G domain-containing ECM (zeige MMRN1 ELISA Kits) ligands

  4. the ligand-binding activity of alpha-dystroglycan is conferred primarily by LARGE modification at Thr (zeige TRH ELISA Kits)-317 and -319, within the highly conserved first 18 amino acids of the mucin (zeige SLC13A2 ELISA Kits)-like domain

  5. LARGE2 (zeige GYLTL1B ELISA Kits) was found to support the maturation of alpha-dystroglycan more effectively than LARGE.

  6. LARGE repression is responsible for the defects in dystroglycan (zeige DAG1 PLURAL_@3194@)-mediated cell adhesion that are observed in epithelium-derived cancer cells and point to a defect of dystroglycan (zeige DAG1 PLURAL_@3194@) glycosylation as a factor in cancer progression

Mouse (Murine) Like-Glycosyltransferase (LARGE) Interaktionspartner

  1. data suggest LARGE overexpression may only be deleterious under a forced regenerative context, such as that resulting from a reduction in FKRP (zeige FKRP ELISA Kits): in the absence of such a defect we show that systemic expression of LARGE can indeed act therapeutically, and that even dramatic LARGE overexpression is well-tolerated in heart and skeletal muscle

  2. MBP1 (zeige ENO1 ELISA Kits) inhibits Ab fibril formation in vitro and demonstrate the ability of MBP1 (zeige ENO1 ELISA Kits) to reduce Ab pathology and improve behavioral performance.

  3. The overexpression of LARGE aggravates muscular dystrophy by suppressing the muscle regeneration and this adverse effect is mediated via reduced expression of IGF-1 (zeige IGF1 ELISA Kits).

  4. Endogenous glucuronyltransferase activity of LARGE or LARGE2 (zeige GYLTL1B ELISA Kits) required for functional modification of alpha-dystroglycan in cells and tissues.

  5. The overexpression of LARGE leads to a shortened lifespan and worsening of the FKRP (zeige FKRP ELISA Kits)-MD phenotype

  6. blocking Large during muscle regeneration results in synthesis of dystroglycan (zeige DAG1 PLURAL_@3194@) with minimal LARGE-glycan repeats in association with less compact basement membrane, immature neuromuscular junctions, and dysfunctional muscle predisposed to dystrophy

  7. Muscular dystrophy defects are primarily due to the effects of LARGE and glycosylated dystroglycan (zeige DAG1 PLURAL_@3194@) in stabilizing the endplate of the neuromuscular junction.

  8. LARGE could act as a bifunctional glycosyltransferase, with xylosyltransferase and glucuronyltransferase activities, which produced repeating units of [-3-xylose-alpha1,3-glucuronic acid-beta1-]; allowed alpha-DG to bind laminin-G domain-containing ECM (zeige MMRN1 ELISA Kits) ligands

  9. Differential glycosylation of alpha-dystroglycan and proteins other than alpha-dystroglycan by like-glycosyltransferase.

  10. a mechanism by which Large competes with galactosyltransferase (zeige a3GALT2 ELISA Kits) to target GlcNAc terminals to induce the functional glycans on alpha-DG

Like-Glycosyltransferase (LARGE) Antigen-Profil

Beschreibung des Gens

This gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Genbezeichner und Symbole assoziert mit LARGE

  • like-glycosyltransferase (LARGE) Antikörper
  • like-glycosyltransferase (large) Antikörper
  • glycosyltransferase-like 1B (GYLTL1B) Antikörper
  • like-glycosyltransferase (Large) Antikörper
  • BPFD36 Antikörper
  • DKFZp459G0120 Antikörper
  • enr Antikörper
  • fg Antikörper
  • froggy Antikörper
  • Gyltl1a Antikörper
  • gyltl1b Antikörper
  • gyltl1b-b Antikörper
  • LARGE Antikörper
  • Mbp-1 Antikörper
  • Mbp1 Antikörper
  • mdc1d Antikörper
  • MDDGA6 Antikörper
  • MDDGB6 Antikörper
  • mKIAA0609 Antikörper
  • myd Antikörper
  • NV15834 Antikörper

Bezeichner auf Proteinebene für LARGE

glycosyltransferase-like protein LARGE1 , glycosyltransferase-like 1A , acetylglucosaminyltransferase-like 1A , acetylglucosaminyltransferase-like protein , like-glycosyltransferase , glycosyltransferase-like protein LARGE1-like , glycosyltransferase-like protein LARGE2 , like-acetylglucosaminyltransferase , myodystrophy , glycosyltransferase-like 1B , glycosyltransferase-like 1B-B , glycosyltransferase-like protein LARGE2-B

GENE ID SPEZIES
418062 Gallus gallus
446213 Danio rerio
470192 Pan troglodytes
717403 Macaca mulatta
100068935 Equus caballus
100118066 Nasonia vitripennis
100174135 Pongo abelii
100346008 Oryctolagus cuniculus
100366528 Saccoglossus kowalevskii
100410756 Callithrix jacchus
100466251 Ailuropoda melanoleuca
423200 Gallus gallus
9215 Homo sapiens
16795 Mus musculus
361368 Rattus norvegicus
474521 Canis lupus familiaris
506466 Bos taurus
734944 Xenopus laevis
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