anti-Like-Glycosyltransferase (LARGE) Antikörper

LARGE, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. Zusätzlich bieten wir Ihnen Like-Glycosyltransferase Proteine (6) und Like-Glycosyltransferase Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
LARGE 9215 O95461
LARGE 16795 Q9Z1M7
LARGE 361368  
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Top anti-Like-Glycosyltransferase Antikörper auf antikoerper-online.de

Showing 10 out of 40 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-LARGE Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Ziege Unkonjugiert ELISA, WB Western Blot: LARGE Antibody [NBP1-49865] - Analysis of LARGE (aa421-433) in Human Kidney lysate (35ug protein in RIPA buffer) using NBP1-49865 at 1 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Anmelden zum Anzeigen 2 bis 4 Tage
311,00 €
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Rind (Kuh) Ziege Unkonjugiert EIA, WB   0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
357,50 €
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Human Ziege Unkonjugiert ELISA, WB 0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
505,48 €
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Fledermaus Ziege Unkonjugiert ELISA, WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
722,86 €
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Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
Details
Rind (Kuh) Ziege Unkonjugiert ELISA   0.1 mg Anmelden zum Anzeigen 2 bis 4 Tage
242,00 €
Details
Human Ziege Unkonjugiert ELISA, WB   0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
472,74 €
Details
Human Ziege Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 3 bis 4 Tage
349,82 €
Details
Human Kaninchen Unkonjugiert WB LARGE antibody used at 1 ug/ml to detect target protein. 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
495,58 €
Details

LARGE Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Rat (Rattus) ,
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Am meisten referenzierte anti-Like-Glycosyltransferase Antikörper

  1. Cow (Bovine) Polyclonal LARGE Primary Antibody für ELISA - ABIN4229228 : de Bernabé, Inamori, Yoshida-Moriguchi, Weydert, Harper, Willer, Henry, Campbell: Loss of alpha-dystroglycan laminin binding in epithelium-derived cancers is caused by silencing of LARGE. in The Journal of biological chemistry 2009 (PubMed)

Weitere Antikörper gegen Like-Glycosyltransferase Interaktionspartner

Human Like-Glycosyltransferase (LARGE) Interaktionspartner

  1. This study suggests LARGE as the first known modifier of plasma antithrombin (zeige SERPINC1 Antikörper).

  2. results reveal that the LARGE-glycan of dystroglycan serves as a tunable extracellular matrix protein scaffold, the extension of which is required for normal skeletal muscle function

  3. LARGE could act as a bifunctional glycosyltransferase (zeige GTDC2 Antikörper), with xylosyltransferase and glucuronyltransferase activities, which produced repeating units of [-3-xylose-alpha1,3-glucuronic acid-beta1-]; allowed alpha-DG to bind laminin-G domain-containing ECM (zeige MMRN1 Antikörper) ligands

  4. the ligand-binding activity of alpha-dystroglycan is conferred primarily by LARGE modification at Thr (zeige TRH Antikörper)-317 and -319, within the highly conserved first 18 amino acids of the mucin (zeige SLC13A2 Antikörper)-like domain

  5. LARGE2 (zeige GYLTL1B Antikörper) was found to support the maturation of alpha-dystroglycan more effectively than LARGE.

  6. LARGE repression is responsible for the defects in dystroglycan-mediated cell adhesion that are observed in epithelium-derived cancer cells and point to a defect of dystroglycan glycosylation as a factor in cancer progression

Mouse (Murine) Like-Glycosyltransferase (LARGE) Interaktionspartner

  1. data suggest LARGE overexpression may only be deleterious under a forced regenerative context, such as that resulting from a reduction in FKRP (zeige FKRP Antikörper): in the absence of such a defect we show that systemic expression of LARGE can indeed act therapeutically, and that even dramatic LARGE overexpression is well-tolerated in heart and skeletal muscle

  2. MBP1 (zeige ENO1 Antikörper) inhibits Ab fibril formation in vitro and demonstrate the ability of MBP1 (zeige ENO1 Antikörper) to reduce Ab pathology and improve behavioral performance.

  3. The overexpression of LARGE aggravates muscular dystrophy by suppressing the muscle regeneration and this adverse effect is mediated via reduced expression of IGF-1 (zeige IGF1 Antikörper).

  4. Endogenous glucuronyltransferase activity of LARGE or LARGE2 (zeige GYLTL1B Antikörper) required for functional modification of alpha-dystroglycan in cells and tissues.

  5. The overexpression of LARGE leads to a shortened lifespan and worsening of the FKRP (zeige FKRP Antikörper)-MD phenotype

  6. blocking Large during muscle regeneration results in synthesis of dystroglycan with minimal LARGE-glycan repeats in association with less compact basement membrane, immature neuromuscular junctions, and dysfunctional muscle predisposed to dystrophy

  7. Muscular dystrophy defects are primarily due to the effects of LARGE and glycosylated dystroglycan in stabilizing the endplate of the neuromuscular junction.

  8. LARGE could act as a bifunctional glycosyltransferase (zeige GTDC2 Antikörper), with xylosyltransferase and glucuronyltransferase activities, which produced repeating units of [-3-xylose-alpha1,3-glucuronic acid-beta1-]; allowed alpha-DG to bind laminin-G domain-containing ECM (zeige MMRN1 Antikörper) ligands

  9. Differential glycosylation of alpha-dystroglycan and proteins other than alpha-dystroglycan by like-glycosyltransferase.

  10. a mechanism by which Large competes with galactosyltransferase to target GlcNAc terminals to induce the functional glycans on alpha-DG

Like-Glycosyltransferase (LARGE) Antigen-Profil

Protein Überblick

This gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Genbezeichner und Symbole assoziert mit LARGE

  • like-glycosyltransferase (LARGE) Antikörper
  • like-glycosyltransferase (large) Antikörper
  • glycosyltransferase-like 1B (GYLTL1B) Antikörper
  • like-glycosyltransferase (Large) Antikörper
  • BPFD36 Antikörper
  • DKFZp459G0120 Antikörper
  • enr Antikörper
  • fg Antikörper
  • froggy Antikörper
  • Gyltl1a Antikörper
  • gyltl1b Antikörper
  • gyltl1b-b Antikörper
  • LARGE Antikörper
  • Mbp-1 Antikörper
  • Mbp1 Antikörper
  • mdc1d Antikörper
  • MDDGA6 Antikörper
  • MDDGB6 Antikörper
  • mKIAA0609 Antikörper
  • myd Antikörper
  • NV15834 Antikörper

Bezeichner auf Proteinebene für LARGE

glycosyltransferase-like protein LARGE1 , glycosyltransferase-like 1A , acetylglucosaminyltransferase-like 1A , acetylglucosaminyltransferase-like protein , like-glycosyltransferase , glycosyltransferase-like protein LARGE1-like , glycosyltransferase-like protein LARGE2 , like-acetylglucosaminyltransferase , myodystrophy , glycosyltransferase-like 1B , glycosyltransferase-like 1B-B , glycosyltransferase-like protein LARGE2-B

GENE ID SPEZIES
418062 Gallus gallus
446213 Danio rerio
470192 Pan troglodytes
717403 Macaca mulatta
100068935 Equus caballus
100118066 Nasonia vitripennis
100174135 Pongo abelii
100346008 Oryctolagus cuniculus
100366528 Saccoglossus kowalevskii
100410756 Callithrix jacchus
100466251 Ailuropoda melanoleuca
423200 Gallus gallus
9215 Homo sapiens
16795 Mus musculus
361368 Rattus norvegicus
474521 Canis lupus familiaris
506466 Bos taurus
734944 Xenopus laevis
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