Leucine Carboxyl Methyltransferase 1 (LCMT1) ELISA Kits

LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA\\; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008].. Zusätzlich bieten wir Ihnen Leucine Carboxyl Methyltransferase 1 Antikörper (62) und Leucine Carboxyl Methyltransferase 1 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Human LCMT1 LCMT1 51451 Q9UIC8
Anti-Maus LCMT1 LCMT1 30949  
Anti-Ratte LCMT1 LCMT1 361643 Q6P4Z6
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Weitere ELISA Kits für Leucine Carboxyl Methyltransferase 1 Interaktionspartner

Human Leucine Carboxyl Methyltransferase 1 (LCMT1) Interaktionspartner

  1. LCMT1-PME-1 (zeige PPME1 ELISA Kits) methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division

  2. alterations in the membrane localization of PP2A and Tau following down-regulation of LCMT1 may lead to PP2A and Tau dysfunction in AD.

  3. Data indicate that PP2A (zeige PPP2R4 ELISA Kits) holoenzyme biogenesis and activity are controlled by five PP2A (zeige PPP2R4 ELISA Kits) modulators, consisting of alpha4, PTPA (zeige PPP2R4 ELISA Kits), LCMT1, PME-1 (zeige PPME1 ELISA Kits) and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled.

  4. GSK-3beta (zeige GSK3b ELISA Kits) can inhibit PP2A (zeige PPP2R4 ELISA Kits) by increasing the inhibitory L309-demethylation involving upregulation of PME-1 (zeige PPME1 ELISA Kits) and inhibition of PPMT1

  5. determined crystal structures of human LCMT-1 in isolation and in complex with PP2A stabilized by a cofactor mimic. The structures show that the LCMT-1 active-site pocket recognizes the carboxyl terminus of PP2A

  6. X-ray crystal structure of human LCMT1 protein in complex with the cofactor S-adenosylmethionine (AdoMet (zeige MAT1A ELISA Kits)) has been solved to a resolution of 2 A.

  7. LCMT-1 is important for normal progression through mitosis and cell survival and is essential for embryonic development

Mouse (Murine) Leucine Carboxyl Methyltransferase 1 (LCMT1) Interaktionspartner

  1. LCMT-1 homozygous knock-out MEFs exhibited hyperphosphorylation of HDAC3, a reported target of the methylation-dependent PP4R1-PP4c complex. Collectively, our data suggest that LCMT-1 coordinately regulates the carboxyl methylation of PP2A-related phosphatases and, consequently, their holoenzyme assembly and function.

  2. In LCMT1 deficiency enzyme activity and methylation of PP2A are reduced in a coordinate fashion, suggesting that LCMT1 is the only PP2A methyltransferase.

  3. Enhanced expression of LCMT1 in cultured neuroblastoma cells, which increases endogenous methylated catalytic C subunit and Balpha levels, induces changes in F-actin organization.

  4. LCMT-1 is important for normal progression through mitosis and cell survival and is essential for embryonic development

Leucine Carboxyl Methyltransferase 1 (LCMT1) Antigen-Profil

Beschreibung des Gens

LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA\; MIM 176915) (De Baere et al., 1999

Genbezeichner und Symbole assoziert mit LCMT1

  • leucine carboxyl methyltransferase 1 (LCMT1) Antikörper
  • leucine carboxyl methyltransferase 1 (lcmt1) Antikörper
  • leucine carboxyl methyltransferase 1 (ANI_1_2090074) Antikörper
  • leucine carboxyl methyltransferase 1 (PTRG_02142) Antikörper
  • leucine carboxyl methyltransferase 1 (MCYG_00360) Antikörper
  • leucine carboxyl methyltransferase 1 (AOR_1_842194) Antikörper
  • leucine carboxyl methyltransferase 1 (Tsp_08223) Antikörper
  • leucine carboxyl methyltransferase 1 (Lcmt1) Antikörper
  • AL033290 Antikörper
  • Lcmt Antikörper
  • LCMT-1 Antikörper
  • MGC114784 Antikörper
  • PPMT1 Antikörper
  • zgc:101094 Antikörper

Bezeichner auf Proteinebene für LCMT1

leucine carboxyl methyltransferase 1 , [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1 , protein phosphatase methyltransferase 1 , protein-leucine O-methyltransferase

GENE ID SPEZIES
416565 Gallus gallus
447907 Danio rerio
467930 Pan troglodytes
548787 Xenopus (Silurana) tropicalis
608360 Canis lupus familiaris
734508 Xenopus laevis
4983025 Aspergillus niger CBS 513.88
6338383 Pyrenophora tritici-repentis Pt-1C-BFP
9225317 Arthroderma otae CBS 113480
10099666 Aspergillus oryzae RIB40
10906787 Trichinella spiralis
100196453 Salmo salar
100528205 Ictalurus punctatus
100606762 Nomascus leucogenys
51451 Homo sapiens
30949 Mus musculus
361643 Rattus norvegicus
618021 Bos taurus
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