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LGALS8 encodes a member of the galectin family. Zusätzlich bieten wir Ihnen Lectin, Galactoside-Binding, Soluble, 8 Kits (52) und Lectin, Galactoside-Binding, Soluble, 8 Proteine (26) und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal LGALS8 Primary Antibody für Func, IA - ABIN2192096
Levy, Arbel-Goren, Hadari, Eshhar, Ronen, Elhanany, Geiger, Zick: Galectin-8 functions as a matricellular modulator of cell adhesion. in The Journal of biological chemistry 2001
Show all 2 Pubmed References
Galectin-8 activates dendritic cells and stimulates antigen-specific immune response elicitation.
these data suggest that Gal-8 promotes the differentiation of highly suppressive Treg cells, which has implications for the treatment of inflammatory and autoimmune diseases.
this study uncovers a unique molecular mechanism of lymphangiogenesis in which galectin-8-dependent crosstalk among VEGF-C (zeige VEGFC Antikörper), podoplanin (zeige PDPN Antikörper) and integrin pathways plays a key role.
Gal (zeige GAL Antikörper)-8mut was unable to induce T-cell proliferation, but efficiently co-stimulated antigen-specific responses, bothin vitroandin vivo.
Gal-8 emerges as an attractive therapeutic candidate.
Galectin-8 induces RANKL (zeige TNFSF11 Antikörper) expression, osteoclastogenesis, and bone mass reduction in mice.
Gal-8 stimulated naive T cells, but had an antiproliferative effect when these cells were activated.A dose of recombinant Gal-8 administered with a suboptimal Ag dose to DO11.10 mice strengthened weak responses in vivo.
a novel role for Gal-8 in collaboration with Gal-1 (zeige LGALS1 Antikörper) in plasma cell formation, and suggest the possibility of using distinct LacNAc ligands to modulate the function of Gals.
The findings of the present study delineate the differential molecular requirements for Gal-8 activities on T-cells, and suggest a dual activity relying on activation state.
downstream effectors of PI3K, including PKB (zeige AKT2 Antikörper) and p70 S6 kinase (zeige PRKACB Antikörper), in part mediate cell adhesion, spreading, and microspike formation induced by galectin-8
Both Gal-8 isoforms led to enhanced adhesion of myeloma cells to vascular endothelium under dynamic shear stress conditions, Gal (zeige GAL Antikörper)-8L (by more than 40-fold) even stronger than Gal (zeige GAL Antikörper)-8S.
Our data indicate that Gal-8 interacts with ALCAM at the surface of breast cancer cells through glycosylation-dependent mechanisms. A novel heterophilic interaction between ALCAM and Gal-8 is demonstrated here, suggesting its physiologic relevance in the biology of breast cancer cells
we detected Gal-8 in human cerebrospinal fluid, suggesting a role in the CNS immune-surveillance circuit. In addition, we show that MS patients generate function-blocking anti-Gal-8 antibodies with pathogenic potential. Furthermore, circulating anti-Gal-8 antibodies associate with relapsing-remitting MS, and not with progressive MS phenotypes, predicting clinical disability at diagnosis within the first year of follow-up
Data suggest that galectin-8 is a potential independent favorable prognostic biomarker for survival and recurrence of patients with gastric cancer after surgery.
Platelet-derived factor V/Va is generated following endocytosis of the plasma-derived molecule by the platelet precursor cells, megakaryocytes, via a two receptor system consisting of LRP-1 (zeige LRP1 Antikörper) and an unidentified specific "binding site".
Gal-8 expression is a potential independent unfavorable prognostic indicator for postoperative recurrence of patients with localized pT1 (zeige ZNF77 Antikörper) clear cell renal cell carcinoma (zeige MOK Antikörper)
The fundamental roles of galectin-8 in human anaplastic large cell lymphoma
The implications of gal-8 in tumor angiogenesis remain to be further explored, but it is exciting to speculate that modulating gal-8-glycan interactions could be used to block lymphatic-vascular connections vital for metastasis
We integrate here the available information on Gal-8 expression in different tumor types and attempt to elucidate associations of its expression and localization with tumor progression[review]
This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified.
lectin, galactoside-binding, soluble, 8
, lectin, galactoside-binding, soluble, 8 (galectin 8)
, galectin 8
, lectin, galactose binding, soluble 5
, galectin-8 variant II
, Po66 carbohydrate binding protein
, po66 carbohydrate-binding protein
, prostate carcinoma tumor antigen 1
, 30 kDa S-type lectin
, lectin, galactose binding, soluble 8
, galectin family xgalectin-VIIIa