LIM Domain Binding 3 (LDB3) ELISA Kits

LDB3 encodes a PDZ domain-containing protein. Zusätzlich bieten wir Ihnen LIM Domain Binding 3 Protein Antikörper (65) und LIM Domain Binding 3 Protein Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Human LDB3 LDB3 11155 O75112
Anti-Maus LDB3 LDB3 24131 Q9JKS4
Anti-Ratte LDB3 LDB3 498587  
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Weitere ELISA Kits für LIM Domain Binding 3 Protein Interaktionspartner

Human LIM Domain Binding 3 (LDB3) Interaktionspartner

  1. this is the first family with Arrhythmogenic right ventricular cardiomyopathy where a mutation in LDB3 is associated with Arrhythmogenic right ventricular cardiomyopathy

  2. Study identified abnormal inclusion of LDB3 exon 11 specific to myotonic dystrophy type at the RNA and protein level; inclusion changed the affinity of LDB3 for PKC, indicating that exon 11 may contribute to the activation of PKC in DM1

  3. results show that MFM-associated ZASP mutations in the actin-binding domain have deleterious effects on the core structure of the Z-discs in skeletal muscle.

  4. Z-band alternatively spliced PDZ motif protein (ZASP) is the major O-linked beta-N-acetylglucosamine-substituted protein in human heart myofibrils

  5. This results of this indicted that One patient harbored the missense mutation c.1719G>A (p.V566M) in the ZASP gene.

  6. ZASP1 can form protein complex with telethonin/T-Cap (zeige TCAP ELISA Kits) and Na(v)1.5. The left ventricular noncompaction-specific ZASP1 mutation can cause loss of function of Na(v)1.5, without significant alteration of the cytoskeletal protein (zeige ACTN1 ELISA Kits) complex.

  7. TNNT3 and LDB3 showed abnormal splicing and appeared more pronounced in myotonic dystrophies type 2 relative to myotonic dystrophies type 1.

  8. the D626N mutation of Cypher/ZASP increases the affinity of the LIM (zeige PDLIM5 ELISA Kits) domain for protein kinase C (zeige PKC ELISA Kits), which may be related to pathogenesis of dilated cardiomyopathy

  9. ZASP/Cypher internal fragments containing either ZM exon 4 or 6 co-localized with alpha-actinin (zeige ACTN1 ELISA Kits) in cultured myoblasts and nonmuscle cells.

  10. ZASP/Cypher anchors PGM1 (zeige PGM1 ELISA Kits) to Z-disc under conditions of stress. The impaired binding of PGM1 (zeige PGM1 ELISA Kits) to ZASP/Cypher might be involved in the pathogenesis of dilated cardiomyopathy.

Mouse (Murine) LIM Domain Binding 3 (LDB3) Interaktionspartner

  1. Cypher and ENH (zeige PDLIM5 ELISA Kits) redundantly play an essential role in sustaining Z-line structure from the earliest stages of cardiac function, and are redundantly required to maintain normal embryonic heart function and embryonic viability.

  2. results show that MFM-associated ZASP mutations in the actin-binding domain have deleterious effects on the core structure of the Z-discs in skeletal muscle.

  3. Results indicte that Cypher/ZASP interacted with the regulatory subunit RIIalpha of PKA.

  4. Data demonstrated that the Z-disk proteins, ZASP, titin (zeige TTN ELISA Kits) and vinculin (zeige VCL ELISA Kits) preferentially bind to alpha-actinin-2 (zeige ACTN2 ELISA Kits).

  5. Deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy.

  6. mutations of a structural/cytoskeletal protein (zeige ADD3 ELISA Kits), such as ZASP, lead to cardiac functional and electric abnormalities.

  7. Cypher isoforms are developmentally regulated in both skeletal and cardiac muscle

  8. Cypher plays a pivotal role in adult cardiac structure and function through protein-protein interactions with other Z-line proteins.

LIM Domain Binding 3 Protein (LDB3) Antigen-Profil

Beschreibung des Gens

This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified\; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains.

Genbezeichner und Symbole assoziert mit LIM Domain Binding 3 (LDB3) ELISA Kits

  • LIM domain binding 3b (ldb3b) Antikörper
  • LIM domain binding 3 S homeolog (ldb3.S) Antikörper
  • LIM domain binding 3 (ldb3) Antikörper
  • LIM domain binding 3 (LDB3) Antikörper
  • LIM domain binding 3 (Ldb3) Antikörper
  • AW742271 Antikörper
  • CMD1C Antikörper
  • CYPHER Antikörper
  • LDB3 Antikörper
  • ldb3l Antikörper
  • LDB3Z1 Antikörper
  • LDB3Z4 Antikörper
  • LVNC3 Antikörper
  • MFM4 Antikörper
  • MGC52706 Antikörper
  • MGC75668 Antikörper
  • ORACLE Antikörper
  • PDLIM6 Antikörper
  • RGD1564875 Antikörper
  • wu:fi31d08 Antikörper
  • ZASP Antikörper
  • zgc:55814 Antikörper

Bezeichner auf Proteinebene für LIM Domain Binding 3 (LDB3) ELISA Kits

LIM domain binding 3 , LIM domain binding 3 like , LIM domain-binding protein 3 , PDZ and LIM domain 6 , Z-band alternatively spliced PDZ-motif protein , protein cypher , PDZ-LIM domain protein , cypher , oracle protein , protein oracle

GENE ID SPEZIES
334100 Danio rerio
379929 Xenopus laevis
394699 Xenopus (Silurana) tropicalis
697140 Macaca mulatta
100348927 Oryctolagus cuniculus
100582910 Nomascus leucogenys
11155 Homo sapiens
536781 Bos taurus
24131 Mus musculus
498587 Rattus norvegicus
479269 Canis lupus familiaris
100151883 Sus scrofa
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