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Location-regulated scaffold connecting MEK to RAF. Zusätzlich bieten wir Ihnen Kinase Suppressor of Ras 2 Antikörper (73) und Kinase Suppressor of Ras 2 Kits (10) und viele weitere Produktgruppen zu diesem Protein an.
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A pleiotropic effect of KSR2-rs7973260 was found on the risk of metabolic syndrome, severe hypertriglyceridemia, and diabetes.
KSR2 deficiency affects stromal interaction molecule 1 (STIM1 (zeige STIM1 Proteine))/ORAI1 puncta formation, which is correlated with cytoskeleton disorganization.
Study explored the role of KSR2 in humans by sequencing 2,101 individuals with severe early-onset obesity and identified multiple rare variants in KSR2 that disrupt signaling through the Raf (zeige RAF1 Proteine)-MEKERK pathway and impair cellular fatty acid oxidation and glucose oxidation in transfected cells.
study demonstrated that miR (zeige MLXIP Proteine)-31 upregulated IL-2 (zeige IL2 Proteine) expression via reduction of its up-stream kinase suppressor, KSR2, and is a component of T cell activation
The involvement of KSR2 in regulation of cell proliferation was predicted by a KSR2-centered network analysis.
KSR (zeige KSR1 Proteine) interacts with a regulatory Raf (zeige RAF1 Proteine) molecule in cis (zeige CISH Proteine) to induce a conformational switch of MEK (zeige MAP2K1 Proteine), facilitating MEK's phosphorylation by a separate catalytic Raf (zeige RAF1 Proteine) molecule in trans
Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia (zeige BCL11A Proteine) cells.
hKSR-2, a new member of the KSR (zeige KSR1 Proteine) family, negatively regulates Cot (zeige MAP3K8 Proteine)-mediated MAP kinase (zeige MAPK1 Proteine) and NF-kappaB (zeige NFKB1 Proteine) pathway signaling
We find that while hKSR-2 blocks MEKK3 (zeige MAP3K3 Proteine) activation, it has little to no effect on other members of the MAP3K family, including MEKK4 (zeige MAP3K4 Proteine), TAK1 (zeige MAP3K7 Proteine), and Ras-Raf (zeige RAF1 Proteine), suggesting that its effects are selective.
These results demonstrate that kinase suppressor of Ras 2 is a direct target of 1,25-dihydroxyvitamin D(3)in HL60 cells, and is required for optimal monocytic differentiation.
KSR2 deficiency affects stromal interaction molecule 1 (STIM1 (zeige STIM1 Proteine))/ORAI1 (zeige TMEM132A Proteine) puncta formation, which is correlated with cytoskeleton disorganization.
KSR2 is essential to tumor cell energy homeostasis and critical to the integration of mitogenic and metabolic signaling pathways
The metabolic phenotype of KSR2 heterozygous (KSR2(+/minus;)) and KSR2(-/-) mice suggests that human KSR2 variants may contribute to a similar phenotype linked to human chromosome 12q24
KSR2 regulates AMPK (zeige PRKAA1 Proteine)-dependent glucose uptake and fatty acid oxidation in mouse embryonic fibroblasts and glycolysis in a neuronal cell line.
The protein phosphatase calcineurin selectively interacts with KSR2 and KSR2 uniquely contributes to Ca2 (zeige CA2 Proteine)+-mediated ERK (zeige EPHB2 Proteine) signaling.
Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
kinase suppressor of Ras 2