Kinase Suppressor of Ras 2 Proteine (KSR2)

Location-regulated scaffold connecting MEK to RAF. Zusätzlich bieten wir Ihnen Kinase Suppressor of Ras 2 Antikörper (73) und Kinase Suppressor of Ras 2 Kits (9) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
KSR2 283455 Q6VAB6
KSR2 333050  
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Showing 6 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
Details
HOST_Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 7 bis 8 Tage
235,20 €
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HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Anmelden zum Anzeigen 6 bis 8 Tage
306,74 €
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HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Anmelden zum Anzeigen 6 bis 8 Tage
306,74 €
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Insektenzellen Human GST tag   10 μg Anmelden zum Anzeigen 7 bis 9 Tage
304,76 €
Details

KSR2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
,
Mouse (Murine)

Weitere Proteine zu Kinase Suppressor of Ras 2 (KSR2) Interaktionspartnern

Human Kinase Suppressor of Ras 2 (KSR2) Interaktionspartner

  1. KSR2 deficiency affects stromal interaction molecule 1 (STIM1 (zeige STIM1 Proteine))/ORAI1 puncta formation, which is correlated with cytoskeleton disorganization.

  2. Study explored the role of KSR2 in humans by sequencing 2,101 individuals with severe early-onset obesity and identified multiple rare variants in KSR2 that disrupt signaling through the Raf (zeige RAF1 Proteine)-MEKERK pathway and impair cellular fatty acid oxidation and glucose oxidation in transfected cells.

  3. study demonstrated that miR (zeige MLXIP Proteine)-31 upregulated IL-2 (zeige IL2 Proteine) expression via reduction of its up-stream kinase suppressor, KSR2, and is a component of T cell activation

  4. The involvement of KSR2 in regulation of cell proliferation was predicted by a KSR2-centered network analysis.

  5. KSR (zeige KSR1 Proteine) interacts with a regulatory Raf (zeige RAF1 Proteine) molecule in cis (zeige CISH Proteine) to induce a conformational switch of MEK (zeige MAP2K1 Proteine), facilitating MEK's phosphorylation by a separate catalytic Raf (zeige RAF1 Proteine) molecule in trans

  6. Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia (zeige BCL11A Proteine) cells.

  7. hKSR-2, a new member of the KSR (zeige KSR1 Proteine) family, negatively regulates Cot (zeige MAP3K8 Proteine)-mediated MAP kinase (zeige MAPK1 Proteine) and NF-kappaB (zeige NFKB1 Proteine) pathway signaling

  8. We find that while hKSR-2 blocks MEKK3 (zeige MAP3K3 Proteine) activation, it has little to no effect on other members of the MAP3K family, including MEKK4 (zeige MAP3K4 Proteine), TAK1 (zeige MAP3K7 Proteine), and Ras-Raf (zeige RAF1 Proteine), suggesting that its effects are selective.

  9. These results demonstrate that kinase suppressor of Ras 2 is a direct target of 1,25-dihydroxyvitamin D(3)in HL60 cells, and is required for optimal monocytic differentiation.

  10. KSR-2 may act as a scaffold protein (zeige HOMER1 Proteine) similar as KSR-1 (zeige KSR1 Proteine) to mediate the MAPK (zeige MAPK1 Proteine) core (RAF (zeige RAF1 Proteine)-MEK (zeige MAP2K1 Proteine)-ERK (zeige EPHB2 Proteine)) signaling but with a distinct RAF (zeige RAF1 Proteine) isoform specificity; KSR-2 may only mediate the A-RAF (zeige ARAF Proteine) signaling while KSR-1 (zeige KSR1 Proteine) transduces signals only from c-RAF (zeige RAF1 Proteine).

Mouse (Murine) Kinase Suppressor of Ras 2 (KSR2) Interaktionspartner

  1. KSR2 deficiency affects stromal interaction molecule 1 (STIM1 (zeige STIM1 Proteine))/ORAI1 (zeige TMEM132A Proteine) puncta formation, which is correlated with cytoskeleton disorganization.

  2. KSR2 is essential to tumor cell energy homeostasis and critical to the integration of mitogenic and metabolic signaling pathways

  3. The metabolic phenotype of KSR2 heterozygous (KSR2(+/minus;)) and KSR2(-/-) mice suggests that human KSR2 variants may contribute to a similar phenotype linked to human chromosome 12q24

  4. KSR2 regulates AMPK (zeige PRKAA1 Proteine)-dependent glucose uptake and fatty acid oxidation in mouse embryonic fibroblasts and glycolysis in a neuronal cell line.

  5. The protein phosphatase calcineurin (zeige PPP3CA Proteine) selectively interacts with KSR2 and KSR2 uniquely contributes to Ca2 (zeige CA2 Proteine)+-mediated ERK (zeige EPHB2 Proteine) signaling.

Kinase Suppressor of Ras 2 (KSR2) Protein Überblick

Protein Überblick

Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

Genbezeichner und Symbole assoziert mit KSR2

  • kinase suppressor of ras 2 (KSR2)
  • kinase suppressor of ras 2 (Ksr2)

Bezeichner auf Proteinebene für KSR2

kinase suppressor of Ras 2

GENE ID SPEZIES
283455 Homo sapiens
333050 Mus musculus
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