anti-Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4) Antikörper

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. Zusätzlich bieten wir Ihnen Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
KIR2DL4 3805 Q99706
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Top anti-Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 Antikörper auf antikoerper-online.de

Showing 10 out of 139 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Kaninchen Unkonjugiert FACS, IHC (p), WB Western blot analysis of KIR2DL4 Antibody (C-term) (ABIN652985) in MDA-MB231 cell line lysates (35 µg/lane). KIR2DL4 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human breast carcinoma reacted with KIR2DL4 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Maus Fluorescein FACS Detection of KIR2DL4/CD158d in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human KIR2DL4/CD158d Fluorescein-conjugated Monoclonal Antibody. Detection of KIR2DL4/CD158d in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human KIR2DL4/CD158d Fluorescein-conjugated Monoclonal Antibody. 25 Tests Anmelden zum Anzeigen 3 bis 4 Tage
116,00 €
Details
Human Maus PE FACS Detection of KIR2DL4/CD158d in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) treated with 150 ng/mL Recombinant Human IL-2. Detection of KIR2DL4/CD158d in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) treated with 150 ng/mL Recombinant Human IL-2. 25 Tests Anmelden zum Anzeigen 3 bis 4 Tage
116,00 €
Details
Human Maus Unkonjugiert EIA, WB Human recombinant protein KIR2DL1, KIR2DL3 and KIR2DL4 (each 20ng per well) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human KIR2DL4 (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and a ECL detection system * Lane 1 : Extracellular domain of KIR2DL1(23-223aa) Lane 2 : Extracellular domain of KIR2DL3(23-223aa) Lane 3 : Extracellular domain of KIR2DL4(44-202aa) 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
341,00 €
Details
Human Maus Unkonjugiert Func, FACS, IF, IP, WB   0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
286,00 €
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Human Maus PE FACS   100 Tests Anmelden zum Anzeigen 7 bis 9 Tage
319,00 €
Details
Human Kaninchen Unkonjugiert EIA, FACS, IHC (p), WB Flow cytometry analysis of MDA-MB231 cells using CD158d / KIR2DL4 Antibody (C-term) Cat.-No AP52370PU-N (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Formalin-fixed and paraffin-embedded human breast carcinoma reacted with CD158d / KIR2DL4 Antibody (C-term) followed which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Human Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
Details
Human Maus Unkonjugiert Agon, CyTOF, FACS Human KIR2DL4/CD158d Antibody Induces IFN-gamma Secretion in NK-92 Cells. Human KIR2DL4/CD158d Monoclonal Antibody induces IFN-gamma secretion in the NK-92 human natural killer lymphoma cell line in a dose-dependent manner, as measured using the Quantikine Human IFN-gamma ELISA Kit. The ED50 for this effect is typically 0.5-2 ug/mL. Human KIR2DL4/CD158d Antibody Induces IFN-gamma Secretion in NK-92 Cells. Human KIR2DL4/CD158d Monoclonal Antibody induces IFN-gamma secretion in the NK-92 human natural killer lymphoma cell line in a dose-dependent manner, as measured using the Quantikine Human IFN-gamma ELISA Kit. The ED50 for this effect is typically 0.5-2 ug/mL. 500 μg Anmelden zum Anzeigen 3 bis 4 Tage
330,00 €
Details

KIR2DL4 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

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Am meisten referenzierte anti-Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 Antikörper

  1. Human Monoclonal KIR2DL4 Primary Antibody für Func, ICC - ABIN1981883 : Goodridge, Witt, Christiansen, Warren: KIR2DL4 (CD158d) genotype influences expression and function in NK cells. in Journal of immunology (Baltimore, Md. : 1950) 2003 (PubMed)
    Show all 5 Pubmed References

  2. Human Monoclonal KIR2DL4 Primary Antibody für Func, ICC - ABIN489933 : LeMaoult, Zafaranloo, Le Danff, Carosella: HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005 (PubMed)
    Show all 5 Pubmed References

  3. Human Monoclonal KIR2DL4 Primary Antibody für Func, ICC - ABIN509568 : Yan, Fan: Residues Met76 and Gln79 in HLA-G alpha1 domain involve in KIR2DL4 recognition. in Cell research 2005 (PubMed)
    Show all 5 Pubmed References

  4. Human Monoclonal KIR2DL4 Primary Antibody für FACS - ABIN4898687 : Baudhuin, Lesport, Sousa, Migraine, Vigneron, Lemaoult, Carosella, Mooney, Favier: HLA-G inhibition of NK-cell cytolytic function is uncoupled from tumor cell lipid raft reorganization. in European journal of immunology 2012 (PubMed)
    Show all 4 Pubmed References

  5. Human Monoclonal KIR2DL4 Primary Antibody für FACS - ABIN4898688 : Cai, Zhang, Zhou, Wang, Fu, Zhang, Shi, Zhang, Yang, Wu, Tien, Wang: Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients. in Clinical immunology (Orlando, Fla.) 2008 (PubMed)
    Show all 4 Pubmed References

  6. Human Polyclonal KIR2DL4 Primary Antibody für FACS, IHC (p) - ABIN652985 : Wi?niewski, Kowal, Wyrodek, Nowak, Majorczyk, Wagner, Pawlak-Adamska, Jankowska, ?lesak, Frydecka, Ku?nierczyk: Genetic polymorphisms and expression of HLA-G and its receptors, KIR2DL4 and LILRB1, in non-small cell lung cancer. in Tissue antigens 2015 (PubMed)

  7. Human Monoclonal KIR2DL4 Primary Antibody für FACS - ABIN4898685 : Dunphy, Guinan, Chorcora, Jayaraman, Traherne, Trowsdale, Pende, Middleton, Gardiner: 2DL1, 2DL2 and 2DL3 all contribute to KIR phenotype variability on human NK cells. in Genes and immunity 2015 (PubMed)

Weitere Antikörper gegen Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 Interaktionspartner

Human Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4) Interaktionspartner

  1. Serum levels of soluble HLA-G (zeige HLAG Antikörper) were similar in CMV- and CMV+ subjects but levels in culture supernatants were significantly higher in cells from CMV+ than from CMV- subjects stimulated with CMV antigens. The HLA-G (zeige HLAG Antikörper) ligand KIR2DL4 was mainly expressed on NK cells and CD56 (zeige NCAM1 Antikörper)+ T cells with no differences between CMV+ and CMV- subjects.

  2. a woman's heterozygosity in HLA-G (zeige HLAG Antikörper) and LILRB1 (zeige LILRB1 Antikörper) might be an advantage for a success of reproduction, but the partner's heterozygosity in 9A/10A KIR2DL4 alleles might not

  3. Decreased level of KIR2DL4 rather than its single nucleotide polymorphism is correlated with the susceptibility of pre-eclampsia

  4. the KIR2DL4 on human mast cells facilitates HLA-G (zeige HLAG Antikörper)-expressing cancer invasion and the subsequent metastasis.

  5. Among 438 Polish people, a weak difference was seen between males and females in 9769 C/A genotypes and alleles. Fertile women had a high frequency of homozygosity for the defective 9A variant, so KIR2DL4 is not absolutely necessary for reproduction.

  6. Array CGH showed a 95 Kb de novo duplication on chromosome 19q13.4 encompassing four killer cell immunoglobulin-like receptor (zeige KIR2DS1 Antikörper) (KIR (zeige GEM Antikörper)) genes.

  7. Results show that HLA-E (zeige HLAE Antikörper) and KIR2DL4 demonstrate evidence of positive selection between human, chimpanzee and gorilla suggesting a main role for immunological adaptations linked to embryo deep invasion of the maternal endometrium during pregnancy.

  8. The unique functional properties of KIR2DL4 may be mediated by self-association of the receptor.

  9. Genetic polymorphism of KIR2DL4, a putative NK cell receptor for HLA-G (zeige HLAG Antikörper), does not influence susceptibility to asthma.

  10. Abs to KIR2DL4 and HLA-G (zeige HLAG Antikörper) did not block NK cell IFN-gamma (zeige IFNG Antikörper) production.

Rhesus Monkey Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4) Interaktionspartner

  1. Higher KIR2DL4 copy numbers is associated with an increased IFN-gamma production in NK cell subsets in SIV-infected Mamu-A*01-negative rhesus macaques.

  2. In the Indian population, two different KIR2DL4 entities are encountered, which differ in their intra-cellular signalling motifs. One genotype contains a complex mutation in the distal region of exon 9, which negates a serine/threonine kinase site.

Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4) Antigen-Profil

Protein Überblick

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\\\\; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the 'framework' loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit KIR2DL4

  • killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 (KIR2DL4) Antikörper
  • killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A (KIR2DL5A) Antikörper
  • CD158D Antikörper
  • G9P Antikörper
  • KIR2DL1 Antikörper
  • KIR2DL4 Antikörper
  • KIR103 Antikörper
  • KIR103AS Antikörper

Bezeichner auf Proteinebene für KIR2DL4

CD158 antigen-like family member D , KIR-103AS , MHC class I NK cell receptor KIR103AS , NK cell receptor , killer Ig receptor , killer cell immunoglobulin-like receptor 2DL4 , killer cell inhibitory receptor 103AS , natural killer cell inhibitory receptor , killer cell immunoglobulin-like receptor 2DL5A , killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 , killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 , killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5 , killer cell immunoglobulin-like receptor KIR2DL4 , killer cell immunogobulin-like receptor two domains long cytoplasmic tail 4

GENE ID SPEZIES
3805 Homo sapiens
282860 Bos taurus
450205 Pan troglodytes
722782 Macaca mulatta
100137355 Papio anubis
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