Junctophilin 2 (JPH2) ELISA Kits

Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Zusätzlich bieten wir Ihnen Junctophilin 2 Antikörper (86) und Junctophilin 2 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Human JPH2 JPH2 57158 Q9BR39
Anti-Maus JPH2 JPH2 59091 Q9ET78
Anti-Ratte JPH2 JPH2 296345 Q2PS20
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Weitere ELISA Kits für Junctophilin 2 Interaktionspartner

Human Junctophilin 2 (JPH2) Interaktionspartner

  1. Junctophilin-2 is cleaved by calpain at multiple sites, resulting in dysfunctional junctophilin-2 truncations.

  2. Our data identify a mechanistic link between microtubule densification and T-tubule remodeling and reveal microtubule-mediated JP2 redistribution as a novel mechanism for T-tubule disruption, loss of excitation-contraction coupling, and heart failure.

  3. The S101R mutation may have an effect upon the stability of the JP2 dyad organization with the potential to alter JP2-protein interactions regulating calcium cycling.

  4. This study demonstrates that both JP1 (zeige JPH1 ELISA Kits) and JP2 in skeletal muscle undergo Ca2 (zeige CA2 ELISA Kits)+-dependent proteolysis by endogenous proteases when the intracellular Ca2 (zeige CA2 ELISA Kits)+ is raised within the physiological range for a sustained period

  5. Hypertrophy in skeletal myotubes induced by junctophilin-2 mutant, Y141H, involves an increase in store-operated Ca2 (zeige CA2 ELISA Kits)+ entry via Orai1 (zeige ORAI1 ELISA Kits).

  6. JP1 (zeige JPH1 ELISA Kits) and JP2 can facilitate the assembly of DHPR (zeige QDPR ELISA Kits) with other proteins of the excitation-contraction coupling machinery

  7. Loss-of-function mutations in JPH2 leads to cardiac-specific JPH2 deficiency and results in impaired cardiac contractility, causing heart failure and increased mortality.

  8. JPH2 levels are reduced in patients with hypertrophic cardiomyopathy. Reduced JPH2 expression results in reduced excitation-contraction coupling gain as well as altered Ca(2 (zeige CA2 ELISA Kits)+) homeostasis, which may be associated with prohypertrophic remodeling.

  9. S165F mutation of junctophilin 2 affects Ca2 (zeige CA2 ELISA Kits)+ signalling in skeletal muscle.

  10. this is the first report on JPH2 mutation associated with hypertrophic cardiomyopathy

Mouse (Murine) Junctophilin 2 (JPH2) Interaktionspartner

  1. This molecular rearrangement is compatible with direct inhibition of RyR (zeige RYR1 ELISA Kits) opening by junctophilin-2 to intrinsically stabilise the Ca(2 (zeige CA2 ELISA Kits)+) signalling properties of the junction and thus the contractile function of the cell.

  2. These results suggested that NCX1 (zeige SLC8A1 ELISA Kits) may play an important role in the proper spatial distribution of LTCC and JP2 in T-tubules in the context of pressure-overloading.

  3. Junctophilin-2 is cleaved by calpain at multiple sites, resulting in dysfunctional junctophilin-2 truncations.

  4. overexpression of JP2 provided significantly protective benefits after pressure overload

  5. Our data identify a mechanistic link between microtubule densification and T-tubule remodeling and reveal microtubule-mediated JP2 redistribution as a novel mechanism for T-tubule disruption, loss of excitation-contraction coupling, and heart failure.

  6. JPH2 may be critical in anchoring the invaginating sarcolemma to the sarcoplasmic reticulum, thereby enabling the maturation of the transverse tubules network

  7. JP2 deficiency abolished the increase in the density of transverse elements

  8. Our data suggest a novel mechanism by which reduced JPH2-mediated stabilization of RyR2 (zeige RYR2 ELISA Kits) due to loss-of-function mutation or reduced JPH2/RyR2 (zeige RYR2 ELISA Kits) ratios can promote SR Ca(2 (zeige CA2 ELISA Kits)+) leak and atrial arrhythmias

  9. This study demonstrates that both JP1 (zeige JPH1 ELISA Kits) and JP2 in skeletal muscle undergo Ca2 (zeige CA2 ELISA Kits)+-dependent proteolysis by endogenous proteases when the intracellular Ca2 (zeige CA2 ELISA Kits)+ is raised within the physiological range for a sustained period

  10. Reducing JP2 expression in ESC-CMs (zeige Cd2ap ELISA Kits) resulted in impaired mitochondrial status due to either abnormal cellular Ca(2 (zeige CA2 ELISA Kits)+) homeostasis or disturbing of juxtaposition.

Junctophilin 2 (JPH2) Antigen-Profil

Beschreibung des Gens

Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described.

Genbezeichner und Symbole assoziert mit Junctophilin 2 (JPH2) ELISA Kits

  • junctophilin 2 (JPH2) Antikörper
  • junctophilin 2 (Jph2) Antikörper
  • 1110002E14Rik Antikörper
  • CMH17 Antikörper
  • jp Antikörper
  • JP-2 Antikörper
  • Jp2 Antikörper

Bezeichner auf Proteinebene für Junctophilin 2 (JPH2) ELISA Kits

junctophilin 2 , junctophilin-2-like , junctophilin type 2 , junctophilin-2 , JP-2

GENE ID SPEZIES
469948 Pan troglodytes
770867 Gallus gallus
100461095 Pongo abelii
57158 Homo sapiens
610874 Canis lupus familiaris
100008613 Oryctolagus cuniculus
59091 Mus musculus
296345 Rattus norvegicus
614651 Bos taurus
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