Isoprenylcysteine Carboxyl Methyltransferase (ICMT) ELISA Kits

ICMT encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. Zusätzlich bieten wir Ihnen Isoprenylcysteine Carboxyl Methyltransferase Antikörper (51) und Isoprenylcysteine Carboxyl Methyltransferase Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
ICMT 23463 O60725
ICMT 57295 Q9EQK7
ICMT 170818  
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Weitere ELISA Kits für Isoprenylcysteine Carboxyl Methyltransferase Interaktionspartner

Human Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Interaktionspartner

  1. ICMT function is critical for the tumorigenesis capacity of naturally occurring mutant KRAS human cancer cells.

  2. simultaneous inhibition of BCR-ABL1 and Icmt may represent a potential therapeutic strategy for CML.

  3. impact of Icmt on tumorigenic processes

  4. Silencing ICMT in osteosarcoma cells decreas (zeige NOTCH1 ELISA Kits)ed Notch1 signaling in (zeige PDX1 ELISA Kits)response to stimulation with cell-surface ligands.

  5. a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion.

  6. modulation of pcCMT activity in retinoic acid (RA)-treated SH-SY5Y neuroblastoma (zeige ARHGEF16 ELISA Kits) cells

  7. ICMTase is a critical component of the redox-sensitive VCAM-1-selective signaling pathway and appears to activate a discrete inflammatory signaling pathway, at least in part, through the methylation of Rac1 in endothelial cells.

  8. findings suggest that inhibition of isoprenylcysteine-O-carboxyl methyltransferase (ICMT) causes endothelial cell apoptosis by attenuation of Ras GTPase (zeige RACGAP1 ELISA Kits) methylation and activation and its downstream antiapoptotic signaling pathway.

  9. These studies identify isoprenylcysteine carboxyl methyltransferase as a potential target for reducing the growth of K-Ras (zeige HRAS ELISA Kits)- and B-Raf (zeige SNRPE ELISA Kits)-induced malignancies.

  10. ICMT inhibition induces endothelial cell apoptosis through GRP94 (zeige HSP90B1 ELISA Kits)

Mouse (Murine) Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Interaktionspartner

  1. simultaneous inhibition of BCR-ABL1 and Icmt may represent a potential therapeutic strategy for CML.

  2. ICMT deficiency precisely phenocopied Notch1 (zeige NOTCH1 ELISA Kits) deficiency in the Pdx1 (zeige PDX1 ELISA Kits)-Cre;LSL-KrasG12D model by exacerbating pancreatic intraepithelial neoplasias, promoting facial papillomas, and derepressing Wnt (zeige WNT2 ELISA Kits) signaling.

  3. findings suggest that inhibition of isoprenylcysteine-O-carboxyl methyltransferase (ICMT) causes endothelial cell apoptosis by attenuation of Ras GTPase (zeige RACGAP1 ELISA Kits) methylation and activation and its downstream antiapoptotic signaling pathway.

  4. inactivating Icmt reduced splenomegaly, the number of immature myeloid cells in peripheral blood, tissue infiltration by myeloid cells, reduced lung tumor development and myeloproliferation phenotypes in a mouse model of K-RAS-induced cancer.

Cow (Bovine) Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Interaktionspartner

  1. ICMT inhibition induces endothelial cell apoptosis through GRP94 (zeige HSP90B1 ELISA Kits)

Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Antigen-Profil

Beschreibung des Gens

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.

Genbezeichner und Symbole assoziert mit ICMT

  • isoprenylcysteine carboxyl methyltransferase (icmt) Antikörper
  • isoprenylcysteine carboxyl methyltransferase (Bcen_5417) Antikörper
  • isoprenylcysteine carboxyl methyltransferase (Acid_0983) Antikörper
  • isoprenylcysteine carboxyl methyltransferase (Bcenmc03_4825) Antikörper
  • Isoprenylcysteine carboxyl methyltransferase (Rpic_1767) Antikörper
  • Isoprenylcysteine carboxyl methyltransferase (Mesil_1887) Antikörper
  • Isoprenylcysteine carboxyl methyltransferase (Slip_1333) Antikörper
  • Isoprenylcysteine carboxyl methyltransferase (Deba_2487) Antikörper
  • Isoprenylcysteine carboxyl methyltransferase (Bresu_2161) Antikörper
  • isoprenylcysteine carboxyl methyltransferase (Mpet_0933) Antikörper
  • isoprenylcysteine carboxyl methyltransferase (Mpet_1639) Antikörper
  • Isoprenylcysteine carboxyl methyltransferase (Saut_0066) Antikörper
  • isoprenylcysteine carboxyl methyltransferase (Intca_3523) Antikörper
  • isoprenylcysteine carboxyl methyltransferase (Deima_2891) Antikörper
  • Isoprenylcysteine carboxyl methyltransferase (Despr_1203) Antikörper
  • Isoprenylcysteine carboxyl methyltransferase (Deipr_0831) Antikörper
  • Isoprenylcysteine carboxyl methyltransferase (Mesop_2650) Antikörper
  • Isoprenylcysteine carboxyl methyltransferase (Mesop_3385) Antikörper
  • Isoprenylcysteine carboxyl methyltransferase (Mesop_3501) Antikörper
  • Isoprenylcysteine carboxyl methyltransferase (Mesop_4056) Antikörper
  • Isoprenylcysteine carboxyl methyltransferase (Mesop_4939) Antikörper
  • Isoprenylcysteine carboxyl methyltransferase (Theth_0229) Antikörper
  • isoprenylcysteine carboxyl methyltransferase (ICMT) Antikörper
  • isoprenylcysteine carboxyl methyltransferase (Icmt) Antikörper
  • 1700008E11Rik Antikörper
  • C80758 Antikörper
  • fcmt Antikörper
  • Gm13095 Antikörper
  • HSTE14 Antikörper
  • im:6895697 Antikörper
  • MST098 Antikörper
  • MSTP098 Antikörper
  • OTTMUSG00000010406 Antikörper
  • pcCMT Antikörper
  • PCMT Antikörper
  • PPMT Antikörper
  • STE14 Antikörper
  • zgc:110258 Antikörper

Bezeichner auf Proteinebene für ICMT

protein-S-isoprenylcysteine O-methyltransferase , isoprenylcysteine carboxyl methyltransferase , Isoprenylcysteine carboxyl methyltransferase , prenylated protein carboxyl methyltransferase , prenylcysteine carboxyl methyltransferase , protein-S isoprenylcysteine O-methyltransferase , FCMT , PPMT , farnesyl cysteine carboxyl methyltransferase , pcCMT , prenylcysteine carboxyl methlytransferase

GENE ID SPEZIES
550281 Danio rerio
4094605 Burkholderia cenocepacia AU 1054
4430863 Candidatus Solibacter usitatus Ellin6076
6127637 Burkholderia cenocepacia MC0-3
6287318 Ralstonia pickettii 12J
9251399 Meiothermus silvanus DSM 9946
9274122 Syntrophothermus lipocalidus DSM 12680
9494959 Desulfarculus baarsii DSM 2075
9504035 Brevundimonas subvibrioides ATCC 15264
9743393 Methanoplanus petrolearius DSM 11571
9744111 Methanoplanus petrolearius DSM 11571
9757577 Sulfurimonas autotrophica DSM 16294
10086362 Intrasporangium calvum DSM 43043
10152256 Deinococcus maricopensis DSM 21211
10173921 Desulfobulbus propionicus DSM 2032
10256310 Deinococcus proteolyticus MRP
10826487 Mesorhizobium opportunistum WSM2075
10827223 Mesorhizobium opportunistum WSM2075
10827339 Mesorhizobium opportunistum WSM2075
10827904 Mesorhizobium opportunistum WSM2075
10828798 Mesorhizobium opportunistum WSM2075
10884973 Thermotoga thermarum DSM 5069
23463 Homo sapiens
397717 Xenopus laevis
419373 Gallus gallus
489628 Canis lupus familiaris
57295 Mus musculus
170818 Rattus norvegicus
100514410 Sus scrofa
785548 Bos taurus
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