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ICMT encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. Zusätzlich bieten wir Ihnen Isoprenylcysteine Carboxyl Methyltransferase Antikörper (52) und Isoprenylcysteine Carboxyl Methyltransferase Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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ICMT catalyzed carboxylmethylation is critical for RAB4A (zeige RAB4A ELISA Kits) activation and interaction with effectors, its localization to endosomes and recycling vesicles, and hence important for RAB4A (zeige RAB4A ELISA Kits)-dependent integrin beta3 recycling to plasma membrane.
ICMT function is critical for the tumorigenesis capacity of naturally occurring mutant KRAS human cancer cells.
simultaneous inhibition of BCR-ABL1 and Icmt may represent a potential therapeutic strategy for CML.
impact of Icmt on tumorigenic processes
Silencing ICMT in osteosarcoma cells decreas (zeige NOTCH1 ELISA Kits)ed Notch1 signaling in (zeige PDX1 ELISA Kits)response to stimulation with cell-surface ligands.
a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion.
modulation of pcCMT activity in retinoic acid (RA)-treated SH-SY5Y neuroblastoma (zeige ARHGEF16 ELISA Kits) cells
ICMTase is a critical component of the redox-sensitive VCAM-1-selective signaling pathway and appears to activate a discrete inflammatory signaling pathway, at least in part, through the methylation of Rac1 in endothelial cells.
findings suggest that inhibition of isoprenylcysteine-O-carboxyl methyltransferase (ICMT) causes endothelial cell apoptosis by attenuation of Ras GTPase (zeige RACGAP1 ELISA Kits) methylation and activation and its downstream antiapoptotic signaling pathway.
These studies identify isoprenylcysteine carboxyl methyltransferase as a potential target for reducing the growth of K-Ras (zeige HRAS ELISA Kits)- and B-Raf (zeige SNRPE ELISA Kits)-induced malignancies.
ICMT deficiency precisely phenocopied Notch1 (zeige NOTCH1 ELISA Kits) deficiency in the Pdx1 (zeige PDX1 ELISA Kits)-Cre;LSL-KrasG12D model by exacerbating pancreatic intraepithelial neoplasias, promoting facial papillomas, and derepressing Wnt (zeige WNT2 ELISA Kits) signaling.
inactivating Icmt reduced splenomegaly, the number of immature myeloid cells in peripheral blood, tissue infiltration by myeloid cells, reduced lung tumor development and myeloproliferation phenotypes in a mouse model of K-RAS-induced cancer.
ICMT inhibition induces endothelial cell apoptosis through GRP94 (zeige HSP90B1 ELISA Kits)
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.
prenylated protein carboxyl methyltransferase
, prenylcysteine carboxyl methyltransferase
, protein-S isoprenylcysteine O-methyltransferase
, protein-S-isoprenylcysteine O-methyltransferase
, farnesyl cysteine carboxyl methyltransferase
, prenylcysteine carboxyl methlytransferase
, isoprenylcysteine carboxyl methyltransferase
, Isoprenylcysteine carboxyl methyltransferase