Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Zusätzlich bieten wir Ihnen IDH2 Proteine (20) und IDH2 Kits (14) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 115 products:
Human Polyclonal IDH2 Primary Antibody für ICC, IF - ABIN4321024
Saha, Gordan, Kleinstiver, Vu, Najem, Yeo, Shi, Kato, Levin, Webber, Damon, Egan, Greninger, McDermott, Garnett, Jenkins, Rieger-Christ, Sullivan, Hezel, Liss, Mizukami, Goyal, Ferrone, Zhu, Joung et al.: Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. ... in Cancer discovery 2016
Show all 2 Pubmed References
Human Polyclonal IDH2 Primary Antibody für ELISA, WB - ABIN4321020
Abbas, Lugthart, Kavelaars, Schelen, Koenders, Zeilemaker, van Putten, Rijneveld, Löwenberg, Valk: Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value. in Blood 2010
Human Polyclonal IDH2 Primary Antibody für ICC, IF - ABIN4321022
Murgia, Nagaraj, Deshmukh, Zeiler, Cancellara, Moretti, Reggiani, Schiaffino, Mann: Single muscle fiber proteomics reveals unexpected mitochondrial specialization. in EMBO reports 2015
Human Polyclonal IDH2 Primary Antibody für WB - ABIN4890344
Shin, Kil, Park: Silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase by small interfering RNA enhances heat shock-induced apoptosis. in Biochemical and biophysical research communications 2008
Human Monoclonal IDH2 Primary Antibody für IHC (p), ELISA - ABIN561418
Gambichler, Terras, Kreuter, Skrygan: Altered global methylation and hydroxymethylation status in vulvar lichen sclerosus: further support for epigenetic mechanisms. in The British journal of dermatology 2014
Cow (Bovine) Polyclonal IDH2 Primary Antibody für WB - ABIN2783282
Vohwinkel, Lecuona, Sun, Sommer, Vadász, Chandel, Sznajder: Elevated CO(2) levels cause mitochondrial dysfunction and impair cell proliferation. in The Journal of biological chemistry 2011
Show all 2 Pubmed References
Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (zeige IDH3B Antikörper)
analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (zeige IDH3B Antikörper)
These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (zeige GRX1 Antikörper) activity.
Leaf IDH activity reduced by 43% in mutant
IDH (zeige IDH1 Antikörper) mutations define a distinct subtype of ICC, a malignancy that is largely refractory to current therapies. Our work demonstrates that IDHm ICC cells are hypersensitive to dasatinib and critically dependent on SRC (zeige SRC Antikörper) activity for survival and proliferation, pointing to new therapeutic strategies against these cancers.
Mutations in the IDH1 (zeige IDH1 Antikörper) and IDH2 genes perturb the epigenome through cytosine methylation, histone post-translational modifications and transcription factors. [review]
IDH2 mutation is associated with high-grade gliomas.
these results suggest a potential relationship between SIRT3 (zeige SIRT3 Antikörper) enzymatic activity, IDH2-K413 acetylation-determined dimerization, and a cancer-permissive phenotype
Identification of IDH1 (zeige IDH1 Antikörper) or IDH2 mutations supports the diagnosis of dedifferentiated chondrosarcoma rather than undifferentiated pleomorphic sarcoma of bone.
There are frequent IDH2 R172 mutations in undifferentiated and poorly-differentiated sinonasal carcinomas.
Results showed that TERT promoter mutational status combined with IDH-mutation allowed simple classification of grade II/III gliomas for stratifying patients and clarifying diagnostic accuracy by supplementing standard histopathological criteria.
Results identified IDH2 rs11540478 as a new susceptibility locus for lung cancer.
Functional studies demonstrated that IDH2 and PIK3CA (zeige PIK3CA Antikörper) hotspot mutations are likely drivers of solid papillary carcinoma with reverse polarity
IDH1 (zeige IDH1 Antikörper) and IDH2 mutants inhibit TET-promoted oxidation of RNA 5-methylcytosine to 5hydroxymethylcytosine.
The enzyme is highly sensitive to Mg(2 (zeige MCOLN1 Antikörper)+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2 (zeige MCOLN1 Antikörper)+)] in mitochondrial energy metabolism.
Findings demonstrate that IDH2 contributes to degeneration of the DA neuron in the neurotoxin model of Parkinson's Disease.
IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice.
IDH2 and NPM1 (zeige GJA1 Antikörper) mutations synergize in the development and maintenance of acute myeloid leukemia (zeige BCL11A Antikörper) stem-like cells.
7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144 leading to atherosclerosis.
These data demonstrate the proto-oncogenic role of mutant IDH2.
The tumor tissue of B16F10 cells transfected with IDH2 antisense cDNA exhibited induction of apoptosis and downregulation of angiogenesis markers.
Data indicate that tumor tissues from idh2-/- ((knock-out) mice had significantly decreased HIF-1alpha (zeige HIF1A Antikörper) expression, blunted mRNA expression of HIF-1alpha (zeige HIF1A Antikörper), VEGF (zeige VEGFA Antikörper), and the glucose transport protein Glut-1 (zeige SLC1A3 Antikörper) was also observed.
IDH2 mutants can cooperate with oncogenic Flt3 (zeige FLT3 Antikörper) or Nras (zeige NRAS Antikörper) alleles to drive leukemia in mice by impairing the differentiation of cells of the myeloid lineage
SIRT3 (zeige SIRT3 Antikörper) protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status
Results suggest that mitochondrial NADP(+)-dependent isocitrate dehydrogenase (zeige IDH1 Antikörper) plays a role in apoptosis induced by high glucose and may contribute to various pathologies associated with the long-term complications of diabetes.
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.
isocitrate dehydrogenase 2 (NADP+), mitochondrial
, isocitrate dehydrogenase [NADP], mitochondrial
, isocitrate dehydrogenase [NADP], mitochondrial-like
, NADP(+)-specific ICDH
, oxalosuccinate decarboxylase
, NADP+-specific isocitrate dehydrogenase
, NADPH-specific isocitrate dehydrogenase