anti-Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) Antikörper

Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. Zusätzlich bieten wir Ihnen ISCU Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ISCU 23479 Q9H1K1
ISCU 288740  
ISCU 66383 Q9D7P6
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Top anti-ISCU Antikörper auf antikoerper-online.de

Showing 10 out of 59 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-Iscu Antibody Titration: 1.0 ug/ml Positive Control: Rat Lung 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert WB ISCU Antibody (C-term) (ABIN1881467) western blot analysis in mouse lung tissue lysates (35 µg/lane). This demonstrates the ISCU antibody detected the ISCU protein (arrow). ISCU Antibody (C-term) (ABIN1881467) western blot analysis in mouse lung tissue lysates (35 µg/lane). This demonstrates the ISCU antibody detected the ISCU protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Maus Unkonjugiert IF, ELISA, WB Immunofluorescence of monoclonal antibody to NIFUN on HeLa cell. [antibody concentration 10 ug/ml] NIFUN monoclonal antibody (M01), clone 3B8-1C4 Western Blot analysis of NIFUN expression in HL-60 . 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$430.00
Details
Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: ISCU Antibody [NBP2-14998] - Paraffin-embedded A549 xenograft, using antibody at 1:500 dilution. Immunocytochemistry/Immunofluorescence: ISCU Antibody [NBP2-14998] - Analysis of methanol-fixed HeLa, using antibody at 1:200 dilution. 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$447.56
Details
Human Maus Unkonjugiert IF, WB Immunofluorescence of monoclonal antibody to NIFUN on HeLa cell (antibody concentration 10 µg/mL). NIFUN monoclonal antibody (M01), clone 3B8-1C4 Western Blot analysis of NIFUN expression in HL-60. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$450.00
Details
Human Maus Unkonjugiert IHC, WB Immunohistochemistry: ISCU Antibody (4F5) [NBP2-45436] - Analysis of Carcinoma of Human pancreas tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Immunohistochemistry: ISCU Antibody (4F5) [NBP2-45436] - Analysis of Carcinoma of Human thyroid tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$447.56
Details
Ratte Kaninchen Unkonjugiert WB Western Blot: ISCU Antibody [NBP1-74072] - Rat Lung Lysate 1ug/ml Gel Concentration 10-20% 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$447.56
Details
Human Maus Unkonjugiert WB   100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$493.17
Details
Human Maus Unkonjugiert IHC (p), WB   100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$493.17
Details

ISCU Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Mouse (Murine)


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Am meisten referenzierte anti-ISCU Antikörper

  1. Human Polyclonal ISCU Primary Antibody für WB - ABIN1881467 : Chan, Zhang, Hemann, Mahoney, Zweier, Loscalzo: MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. in Cell metabolism 2009 (PubMed)
    Show all 5 Pubmed References

  2. Human Monoclonal ISCU Primary Antibody für IF, ELISA - ABIN565100 : Heather, Cole, Tan, Ambrose, Pope, Abd-Jamil, Carter, Dodd, Yeoh, Schofield, Clarke: Metabolic adaptation to chronic hypoxia in cardiac mitochondria. in Basic research in cardiology 2012 (PubMed)

Weitere Antikörper gegen ISCU Interaktionspartner

Human Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) Interaktionspartner

  1. We have shown that ASO treatment diminished aberrant splicing and increased ISCU protein levels in both patient fibroblasts and patient myotubes in a concentration dependent fashion. Upon ASO treatment, levels of SDHB (zeige SDHB Antikörper) in patient myotubular cell lines increased to levels observed in control myotubular cell lines

  2. The NFS1 (zeige NFS1 Antikörper)/ISD11 (zeige LYRM4 Antikörper) complex further interacts with scaffold protein (zeige HOMER1 Antikörper) ISCU and regulator protein frataxin (zeige FXN Antikörper), thereby forming a quaternary complex for Fe-S cluster formation.

  3. Molecular dynamics flexible fitting of protein structures docked into the EM map of the model revealed a [FXN (zeige FXN Antikörper)(42-210)]24.[NFS1 (zeige NFS1 Antikörper)]24.[ISD11 (zeige LYRM4 Antikörper)]24.[ISCU]24 complex, consistent with the measured 1:1:1:1 stoichiometry of its four components.

  4. ISCU expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 (zeige TP53 Antikörper) mutation.

  5. Thus, driven by acquired (hypoxia) or genetic causes, the miR (zeige MLXIP Antikörper)-210-ISCU1/2 regulatory axis is a pathogenic lynchpin causing iron-sulfur deficiency and pulmonary hypertension.

  6. The core Fe-S biosynthetic enzymatic complex generated [2Fe-2S] cluster intermediates that converted to stable [2Fe-2S] clusters bound to uncomplexed ISCU2.

  7. IscU is a new substrate of MK2 (zeige KCNA2 Antikörper) both in Drosophila cells and in human cells

  8. Fe-S assembly protein (ISCU2) and frataxin (zeige FXN Antikörper) convert substrates l-cysteine, ferrous iron, and electrons into Fe-S clusters.

  9. the G50E iron-sulfur cluster scaffold protein (zeige NFU1 Antikörper) (ISCU) mutation has a role in mitochondrial myopathy

  10. NFS1 (zeige NFS1 Antikörper) binds preferentially to the D-state of ISCU while mtHSP70 (zeige HSPA9 Antikörper) binds preferentially to the D-state of ISCU and HSC20 (zeige HSCB Antikörper) binds preferentially to the S-state of ISCU.

Mouse (Murine) Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) Interaktionspartner

  1. ISCU expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 (zeige TP53 Antikörper) mutation.

  2. IscU is a marginally stable protein at low ionic strength to the point that undergoes cold denaturation at around -8 degrees C with a corresponding dramatic decrease of enthalpy, which is consistent with the fluxional nature of the protein.

  3. mTORC1 associates with ISCU and phosphorylates ISCU at serine 14. This phosphorylation stabilized ISCU protein.

  4. Data show that complete loss of ISCU results in early embryonic death and confirm a fundamental role for ISCU in mammals.

  5. While IFN-gamma (zeige IFNG Antikörper) alone induced Nfs1 (zeige NFS1 Antikörper) protein instability, LPS (zeige TLR4 Antikörper) triggered a delayed decline of Nfs1 (zeige NFS1 Antikörper), rather involving transcriptional events or mRNA instability.

ISCU Antigen-Profil

Protein Überblick

Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria.

Genbezeichner und Symbole assoziert mit ISCU

  • iron-sulfur cluster assembly enzyme ISCU, mitochondrial (LOC409130) Antikörper
  • iron-sulfur cluster assembly enzyme (ISCU) Antikörper
  • iron-sulfur cluster assembly enzyme a (iscua) Antikörper
  • iron-sulfur cluster assembly enzyme (Iscu) Antikörper
  • 2310020H20Rik Antikörper
  • AA407971 Antikörper
  • HML Antikörper
  • hnifU Antikörper
  • ISU2 Antikörper
  • Nifu Antikörper
  • Nifun Antikörper
  • RGD1309562 Antikörper
  • si:ch211-191d15.3 Antikörper
  • zC191D15.3 Antikörper

Bezeichner auf Proteinebene für ISCU

iron-sulfur cluster assembly enzyme ISCU, mitochondrial , iron-sulfur cluster scaffold homolog (E. coli) , iron-sulfur cluster assembly enzyme , IscU iron-sulfur cluster scaffold homolog (E. coli) , NifU-like N-terminal domain containing , zC191D15.3 (novel protein with leucine-rich repeat domains) , IscU iron-sulfur cluster scaffold homolog , iron-sulfur cluster scaffold homolog , nifU-like N-terminal domain-containing protein , nifU-like protein , ISCU2

GENE ID SPEZIES
409130 Apis mellifera
477527 Canis lupus familiaris
514789 Bos taurus
497179 Danio rerio
23479 Homo sapiens
288740 Rattus norvegicus
66383 Mus musculus
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