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Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. Zusätzlich bieten wir Ihnen ISCU Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 59 products:
Human Polyclonal ISCU Primary Antibody für WB - ABIN1881467
Chan, Zhang, Hemann, Mahoney, Zweier, Loscalzo: MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. in Cell metabolism 2009
Show all 5 Pubmed References
Human Monoclonal ISCU Primary Antibody für IF, ELISA - ABIN565100
Heather, Cole, Tan, Ambrose, Pope, Abd-Jamil, Carter, Dodd, Yeoh, Schofield, Clarke: Metabolic adaptation to chronic hypoxia in cardiac mitochondria. in Basic research in cardiology 2012
We have shown that ASO treatment diminished aberrant splicing and increased ISCU protein levels in both patient fibroblasts and patient myotubes in a concentration dependent fashion. Upon ASO treatment, levels of SDHB (zeige SDHB Antikörper) in patient myotubular cell lines increased to levels observed in control myotubular cell lines
The NFS1 (zeige NFS1 Antikörper)/ISD11 (zeige LYRM4 Antikörper) complex further interacts with scaffold protein (zeige HOMER1 Antikörper) ISCU and regulator protein frataxin (zeige FXN Antikörper), thereby forming a quaternary complex for Fe-S cluster formation.
Molecular dynamics flexible fitting of protein structures docked into the EM map of the model revealed a [FXN (zeige FXN Antikörper)(42-210)]24.[NFS1 (zeige NFS1 Antikörper)]24.[ISD11 (zeige LYRM4 Antikörper)]24.[ISCU]24 complex, consistent with the measured 1:1:1:1 stoichiometry of its four components.
ISCU expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 (zeige TP53 Antikörper) mutation.
Thus, driven by acquired (hypoxia) or genetic causes, the miR (zeige MLXIP Antikörper)-210-ISCU1/2 regulatory axis is a pathogenic lynchpin causing iron-sulfur deficiency and pulmonary hypertension.
The core Fe-S biosynthetic enzymatic complex generated [2Fe-2S] cluster intermediates that converted to stable [2Fe-2S] clusters bound to uncomplexed ISCU2.
IscU is a new substrate of MK2 (zeige KCNA2 Antikörper) both in Drosophila cells and in human cells
Fe-S assembly protein (ISCU2) and frataxin (zeige FXN Antikörper) convert substrates l-cysteine, ferrous iron, and electrons into Fe-S clusters.
the G50E iron-sulfur cluster scaffold protein (zeige NFU1 Antikörper) (ISCU) mutation has a role in mitochondrial myopathy
NFS1 (zeige NFS1 Antikörper) binds preferentially to the D-state of ISCU while mtHSP70 (zeige HSPA9 Antikörper) binds preferentially to the D-state of ISCU and HSC20 (zeige HSCB Antikörper) binds preferentially to the S-state of ISCU.
IscU is a marginally stable protein at low ionic strength to the point that undergoes cold denaturation at around -8 degrees C with a corresponding dramatic decrease of enthalpy, which is consistent with the fluxional nature of the protein.
mTORC1 associates with ISCU and phosphorylates ISCU at serine 14. This phosphorylation stabilized ISCU protein.
Data show that complete loss of ISCU results in early embryonic death and confirm a fundamental role for ISCU in mammals.
While IFN-gamma (zeige IFNG Antikörper) alone induced Nfs1 (zeige NFS1 Antikörper) protein instability, LPS (zeige TLR4 Antikörper) triggered a delayed decline of Nfs1 (zeige NFS1 Antikörper), rather involving transcriptional events or mRNA instability.
Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria.
iron-sulfur cluster assembly enzyme ISCU, mitochondrial
, iron-sulfur cluster scaffold homolog (E. coli)
, iron-sulfur cluster assembly enzyme
, IscU iron-sulfur cluster scaffold homolog (E. coli)
, NifU-like N-terminal domain containing
, zC191D15.3 (novel protein with leucine-rich repeat domains)
, IscU iron-sulfur cluster scaffold homolog
, iron-sulfur cluster scaffold homolog
, nifU-like N-terminal domain-containing protein
, nifU-like protein