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The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. Zusätzlich bieten wir Ihnen und und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal IL27 Primary Antibody für ELISA - ABIN2474993
Batten, Ghilardi: The biology and therapeutic potential of interleukin 27. in Journal of molecular medicine (Berlin, Germany) 2007
endogenous levels of IL-27 affected the oncogenic properties of mutant p53 (zeige TP53 Antikörper) in vivo in a Li-Fraumeni mouse model. Lack of IL-27 signaling led to shortened survival times and increased incidence of osteosarcomas.
Interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhage. Interleukin-27 promotes the tissue-protecting functions of neutrophils via, at least partly, the induction of lactoferrin (zeige LTF Antikörper).
Serum IL-27 levels and cardiac IL-27 mRNA expression were significantly increased after LPS injection compared with control specimens.
these findings highlight critical roles for IFN-gamma (zeige IFNG Antikörper) and IL-27 in the mechanism of respiratory syncytial virus-induced exacerbation
IL-27-induced Sca-1 (zeige Ly6a Antikörper)(+) T cells had increased expression of effector/memory-associated transcription factor T-bet, Eomes (zeige EOMES Antikörper) and Blimp1 (zeige PRDM1 Antikörper).
found that during respiratory virus infection the prototypic inflammatory cytokine IL-6 (zeige IL6 Antikörper) is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27
We demonstrate that IL-27-deficiency is linked to increased mucosal presence of ILC2 in a model of inflammatory lung disease. Moreover, IL-27-treatment inhibited ILC2 proliferation and cytokine production and significantly reduced their accumulation in vivo.
These data suggest a novel role of the sympathetic neuroendocrine system for the modulation of IL-27-dependent acute inflammation.
results identified a novel mechanism of action of IL-27 on Tregs in the context of cancers.
These findings provide new evidence that IL-27 plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1beta (zeige IL1B Antikörper) secretion levels triggered by dual LPS (zeige TLR4 Antikörper)-ATP stimulation.
serum interleukin-27 and interleukin-35 concentrations in patients with Guillain-Barre syndrome
Expression of IL-27 in the serum was markedly increased in patients with sepsis-induced myocardial dysfunction compared with that in controls.
IL-27 significantly inhibited the M2 macrophages polarization and dampened the proliferation, migration and metastasis of pancreatic cancer cells and as well enhanced the efficacy of gemcitabine.
IL-27 increased NLRP3 (zeige NLRP3 Antikörper) inflammasome activation in monocytes with enhanced release of IL-1 beta (zeige IL1B Antikörper).
this study shows that interleukin 27 is up-regulated in patients with active inflammatory bowel disease
IL-27 polymorphisms might play a protective role for the development of ulcerative colitis in the Mexican population
IL-27 stimulation activated STAT1 (zeige STAT1 Antikörper) and STAT3 (zeige STAT3 Antikörper) in HeLa and T98G cells, suggesting that IL-27 engages the STAT1 (zeige STAT1 Antikörper)/3 pathway, which then leads to the upregulation of IL-6 (zeige IL6 Antikörper), IP-10 (zeige CXCL10 Antikörper), and MIG (zeige CXCL9 Antikörper)
IL-27 and IL-37 limit the induction of particular T cell subsets along with cytokine responses in S. stercoralis infections, which suggest the importance of IL-27 and IL-37 in immune modulation in a chronic helminth infection.
IL-27 is a pivotal regulator in endometriotic immune tolerance by triggering Th17 cells to produce IL-10 (zeige IL10 Antikörper).
HIV and Tat (zeige TAT Antikörper) inhibit LPS (zeige IRF6 Antikörper)-induced IL-27 production in human macrophages via distinct mechanisms: Tat (zeige TAT Antikörper) through the inhibition of cIAP-1 (zeige BIRC2 Antikörper)-TRAF-6 (zeige TRAF6 Antikörper) and subsequent inhibition of PI3K (zeige PIK3CA Antikörper) and p38 (zeige CRK Antikörper) MAPKs, whereas HIV through the inhibition of p38 MAPK (zeige MAPK14 Antikörper) activation.
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
IL-27 p28 subunit
, IL-27 subunit alpha
, interleukin 30
, interleukin-27 subunit alpha