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The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. Zusätzlich bieten wir Ihnen IL27 Antikörper (165) und IL27 Kits (51) und viele weitere Produktgruppen zu diesem Protein an.
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Human IL27 Protein expressed in Wheat germ - ABIN1307800
Di Meo, Airoldi, Sorrentino, Zorzoli, Esposito, Di Carlo: Interleukin-30 expression in prostate cancer and its draining lymph nodes correlates with advanced grade and stage. in Clinical cancer research : an official journal of the American Association for Cancer Research 2014
Show all 2 Pubmed References
IL-27 increased NLRP3 (zeige NLRP3 Proteine) inflammasome activation in monocytes with enhanced release of IL-1 beta (zeige IL1B Proteine).
this study shows that interleukin 27 is up-regulated in patients with active inflammatory bowel disease
IL-27 polymorphisms might play a protective role for the development of ulcerative colitis in the Mexican population
IL-27 stimulation activated STAT1 (zeige STAT1 Proteine) and STAT3 (zeige STAT3 Proteine) in HeLa and T98G cells, suggesting that IL-27 engages the STAT1 (zeige STAT1 Proteine)/3 pathway, which then leads to the upregulation of IL-6 (zeige IL6 Proteine), IP-10 (zeige CXCL10 Proteine), and MIG (zeige CXCL9 Proteine)
IL-27 and IL-37 limit the induction of particular T cell subsets along with cytokine responses in S. stercoralis infections, which suggest the importance of IL-27 and IL-37 in immune modulation in a chronic helminth infection.
IL-27 is a pivotal regulator in endometriotic immune tolerance by triggering Th17 cells to produce IL-10 (zeige IL10 Proteine).
HIV and Tat (zeige TAT Proteine) inhibit LPS (zeige IRF6 Proteine)-induced IL-27 production in human macrophages via distinct mechanisms: Tat (zeige TAT Proteine) through the inhibition of cIAP-1 (zeige BIRC2 Proteine)-TRAF-6 (zeige TRAF6 Proteine) and subsequent inhibition of PI3K (zeige PIK3CA Proteine) and p38 (zeige CRK Proteine) MAPKs, whereas HIV through the inhibition of p38 MAPK (zeige MAPK14 Proteine) activation.
IL27 (zeige EBI3 Proteine) recapitulates IFN-gamma (zeige IFNG Proteine) responses in hepatocellular carcinoma cells, but is inhibited by IL6 (zeige IL6 Proteine)-type cytokines.
These findings provide new evidence that IL-27 plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1beta (zeige IL1B Proteine) secretion levels triggered by dual LPS (zeige IRF6 Proteine)-ATP stimulation.
IL-27 enhanced the cytotoxicity and suppressed the proliferation of ovarian cancer cells
IL-27-induced Sca-1(+) T cells had increased expression of effector/memory-associated transcription factor T-bet, Eomes (zeige EOMES Proteine) and Blimp1 (zeige PRDM1 Proteine).
found that during respiratory virus infection the prototypic inflammatory cytokine IL-6 (zeige IL6 Proteine) is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27
We demonstrate that IL-27-deficiency is linked to increased mucosal presence of ILC2 in a model of inflammatory lung disease. Moreover, IL-27-treatment inhibited ILC2 proliferation and cytokine production and significantly reduced their accumulation in vivo.
These data suggest a novel role of the sympathetic neuroendocrine system for the modulation of IL-27-dependent acute inflammation.
results identified a novel mechanism of action of IL-27 on Tregs in the context of cancers.
These findings provide new evidence that IL-27 plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1beta (zeige IL1B Proteine) secretion levels triggered by dual LPS (zeige TLR4 Proteine)-ATP stimulation.
findings show that PGE2 inhibits IL-27 production in macrophages and in splenic conventional dendritic cells; and identify a novel pathway consisting of signaling through EP2/EP4-->induction of cAMP-->downregulation of IFN regulatory factor 1 expression and binding to the p28 IFN-stimulated response element site
these data provide the first evidence that IL-27 signals directly to B (zeige TDO2 Proteine) cells promote GCs (zeige UGCG Proteine) and support the role of IL-27 in lupus.
this study shows that IL-27 plays an important role in immune response and pathogen clearance during infection with Candida parapsilosis
Inhibition of IL-27p28 also enhanced the suppressive capacity of adoptively transferred CD4 (zeige CD4 Proteine)(+) nTregs by increasing the stability of Foxp3 (zeige FOXP3 Proteine) expression.
The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
IL-27 p28 subunit
, IL-27 subunit alpha
, interleukin 30
, interleukin-27 subunit alpha
, interluekin 27
, interleukin 27
, interleukin 27 p28 subunit