Interferon Regulatory Factor 6 Proteine (IRF6)

IRF6 encodes a member of the interferon regulatory transcription factor (IRF) family. Zusätzlich bieten wir Ihnen IRF6 Antikörper (98) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
IRF6 3664 O14896
IRF6 54139 P97431
Ratte IRF6 IRF6 364081  
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Showing 8 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
640,00 €
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HOST_Escherichia coli (E. coli) Maus His tag,T7 tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
680,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 7 bis 14 Tage
811,90 €
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HOST_Escherichia coli (E. coli) Maus Unkonjugiert   100 μg Anmelden zum Anzeigen 7 bis 14 Tage
851,19 €
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IRF6 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine) ,
,

Weitere Proteine zu Interferon Regulatory Factor 6 (IRF6) Interaktionspartnern

Human Interferon Regulatory Factor 6 (IRF6) Interaktionspartner

  1. In all three affecteds the known pathogenic mutation c.265A>G, p.Lys89Glu in IRF6 was identified. While inter- as well as intra-familial variability has been described in IRF6-related disorders, the occurrence of a typical Van (zeige TNIP1 Proteine) der (zeige GDF3 Proteine) Woude Syndrome without any other anomalies as well as a diagnosis of Popliteal pterygium syndrome in the same family is rare.

  2. Association between IRF6 and 8q24 polymorphisms and nonsyndromic cleft lip with or without cleft palate

  3. Here, we demonstrate the protein functions of human IRF6 missense gene variants could be rapidly assessed in detail by their abilities to rescue the irf6 -/- phenotype in zebrafish through variant mRNA microinjections at the one-cell stage.

  4. The data presented suggest an important role for cytoplasmic IRF6 in regulating the availability or localization of the NME1 (zeige NME1 Proteine)/2 complex and thus the dynamic behavior of epithelia during lip/palate development.

  5. IRF6 dysregulation may be involved in the development of Vulvar Squamous Cell Carcinoma from vulvar lichen sclerosus (VLS). Methylation of the IRF6 promoter may be a marker of cancer risk in patients with VLS.

  6. Here, the authors have established that IRF6 promotes the differentiation of oral keratinocytes in response to Porphyromonas gingivalis.

  7. It has been shown that pathogenic IRF6 mutations are likely to occur in a small fraction (~0.3%) of individuals with apparent nonsyndromic orofacial cleft, across multiple ethnic groups.

  8. The 8q24 region plays a role in cleft lip/palate and the IRF6 G/A haplotype (rs2235371/rs642961) increases the risk for oral cleft in the Brazilian population.

  9. Studied the correlation of IRF6 rs642961 polymorphism and NSCL (zeige NHLH1 Proteine)/P in Iranian NSCL (zeige NHLH1 Proteine)/P families; the family-based association analysis revealed no significant association between IRF6 rs642961 genotypes and an increased NSCL (zeige NHLH1 Proteine)/P risk.

  10. Mutations in IRF6 cause Van der Woude and popliteal pterygium syndrome and contribute to nonsyndromic cleft lip phenotypes but have not previously been associated with a PRS phenotype.

Zebrafish Interferon Regulatory Factor 6 (IRF6) Interaktionspartner

  1. Here, we demonstrate the protein functions of human IRF6 missense gene variants could be rapidly assessed in detail by their abilities to rescue the irf6 -/- phenotype in zebrafish through variant mRNA microinjections at the one-cell stage.

  2. Fish IRF6 is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 (zeige MYD88 Proteine) and TBK1 (zeige TBK1 Proteine), suggesting that differences in the IRF6 regulation pattern exist between lower and higher vertebrates.

  3. Authors report that Kruppel-like factor 17 (Klf17 (zeige KLF17 Proteine)), like Grhl3 (zeige GRHL3 Proteine), acts downstream of Irf6 in this network in zebrafish periderm.

  4. In zebrafish periderm, grainyhead-like 3 (grhl3 (zeige GRHL3 Proteine)) (an ancient regulator of the epidermal permeability barrier), was identified as acting downstream of Irf6. Simultaneous inhibition of grhl1 (zeige GRHL1 Proteine) and grhl3 (zeige GRHL3 Proteine) disrupted periderm differentiation in zebrafish.

  5. analysis of zebrafish expression of IRF6

  6. These experiments reveal a conserved role for maternally-encoded Irf6 in differentiation of a simple epithelium in X. laevis and D. rerio.

Mouse (Murine) Interferon Regulatory Factor 6 (IRF6) Interaktionspartner

  1. IRF6 suppresses PPARgamma (zeige PPARG Proteine) through binding IRF (zeige TRIM63 Proteine) recognition sites located upstream of the PPARgamma (zeige PPARG Proteine) coding region. Taken together, the results suggest that an IRF6/PPARgamma (zeige PPARG Proteine) regulatory axis suppresses anti-inflammatory responses in bone marrow-derived macrophages and provides references for future study addressing dysregulated metabolic and immunologic homeostasis of obese adipose tissue.

  2. Irf6 and RTK signaling interact in regulating periderm differentiation and function, as well as provide a rationale to screen for epistatic interactions between variants in IRF6 and RTK signaling pathway genes in human orofacial clefting populations.

  3. These data provide the first mechanistic insight into the heightened caries susceptibility associated with CLP (zeige HAPLN1 Proteine) and indicate a direct role for the major CLP (zeige HAPLN1 Proteine) gene Irf6 in salivary gland development and a significant role in regulating oral immunity in mice.

  4. that downregulation of interferon regulatory factor 6 affords protection against TNI (zeige TNNI2 Proteine) through Akt (zeige AKT1 Proteine)-eNOS (zeige NOS3 Proteine) pathway-mediated antioxidative and anti-inflammatory activity

  5. Irf6 is required for resistance to Lipopolysaccharides-induced endotoxic shock. In addition, Irf6-deficient bone marrow-derived neutrophils exhibited increased chemotactic index and velocity compared with wild-type cells in vitro.

  6. TGFbeta3 increases IRF6 expression and subsequently regulates SNAI2 (zeige SNAI2 Proteine) expression; IRF6 appears to regulate epithelial mesenchymal transition during palatal fusion via SNAI2 (zeige SNAI2 Proteine).

  7. Pvrl1 (zeige PVRL1 Proteine) is a bona fide target gene of the transcription factor p63 (zeige CKAP4 Proteine), whereas Pvrl4 (zeige PVRL4 Proteine) regulation is linked to epidermal differentiation and is under Irf6

  8. Data suggest that Irf6 functions through the RhoA (zeige RHOA Proteine) pathway to regulate cellular migration.

  9. These results support a role for IRF6 in brain morphometry and provide evidence for a potential genetic link to abnormal brain development in orofacial clefting.

  10. Irf6 plays important cell-autonomous and non-cell-autonomous roles in muscular differentiation and cytoskeletal formation in the tongue.

IRF6 Protein Überblick

Protein Überblick

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit IRF6

  • interferon regulatory factor 6 (IRF6)
  • interferon regulatory factor 6 (irf6)
  • interferon regulatory factor 6 (Irf6)
  • AI876454 Protein
  • DKFZp469E012 Protein
  • E230028I05Rik Protein
  • IRF6 Protein
  • LPS Protein
  • mirf6 Protein
  • OFC6 Protein
  • PIT Protein
  • PPS Protein
  • PPS1 Protein
  • VWS Protein
  • VWS1 Protein
  • xIRF-6 Protein
  • zgc:63500 Protein

Bezeichner auf Proteinebene für IRF6

interferon regulatory factor 6 , interferon regulatory factor 6-like , IRF-6

GENE ID SPEZIES
443083 Ovis aries
457701 Pan troglodytes
594908 Xenopus (Silurana) tropicalis
712958 Macaca mulatta
100174467 Pongo abelii
100402804 Callithrix jacchus
100594750 Nomascus leucogenys
3664 Homo sapiens
393570 Danio rerio
443771 Xenopus laevis
480015 Canis lupus familiaris
397521 Sus scrofa
614253 Bos taurus
54139 Mus musculus
364081 Rattus norvegicus
100349520 Oryctolagus cuniculus
419863 Gallus gallus
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