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IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. Zusätzlich bieten wir Ihnen Interferon Regulatory Factor 2 Antikörper (140) und Interferon Regulatory Factor 2 Proteine (17) und viele weitere Produktgruppen zu diesem Protein an.
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In a genome wide are study to identify acute kidney injury risk in critically ill patients, the locus on chromosome 4, located 150 kb upstream of IRF2 was identified to regulate immunity pathways related to kidney disease risk gene APOL1 (zeige APOL1 ELISA Kits). Disruption of IRF-2 has been found to up-regulate the inflammatory response to infection.
Study shows that IRF2 knockdown inhibits growth, colony formation of OCI/AML-2 (zeige RUNX3 ELISA Kits), OCI/AML-3 (zeige RUNX2 ELISA Kits), and THP-1 (zeige GLI2 ELISA Kits) cells. In addition, IRF2 knockdown induces apoptosis of acute myeloid leukemia (zeige BCL11A ELISA Kits) (AML (zeige RUNX1 ELISA Kits)) cells by regulating apoptotic effectors. Further mechanism analysis shows that INPP4B (zeige INPP4B ELISA Kits) contributes to the effects of IRF2 on apoptosis and growth of AML (zeige RUNX1 ELISA Kits) cells. Thus, IRF2 serves as an important regulator in AML (zeige RUNX1 ELISA Kits) by targeting INPP4B (zeige INPP4B ELISA Kits).
miR (zeige MLXIP ELISA Kits)-450 targets IRF2 and thus supresses lung cancer cell proliferation and invasion.
It might play as a tumor suppressor by regulating P53 (zeige TP53 ELISA Kits) signaling in gastric cancer.
the association of IRF2 with susceptibility to systemic lupus erythematosus
Data suggest that interferon (zeige IFNA ELISA Kits) regulatory factors 1 and 2 (IRF1 (zeige IRF1 ELISA Kits) and IRF2) may serve as potential targets of therapy.
miR (zeige MLXIP ELISA Kits)-221 directly inhibits the expression of SOCS3 (zeige SOCS3 ELISA Kits) and IRF2.
KGF (zeige FGF7 ELISA Kits) could up-regulate IL-7 (zeige IL7 ELISA Kits) expression through the STAT1 (zeige STAT1 ELISA Kits)/IRF-1 (zeige IRF1 ELISA Kits), IRF-2 signaling pathway, which is a new insight in potential effects of KGF (zeige FGF7 ELISA Kits) on the intestinal mucosal immune system.
IFN regulatory factor 2 (Irf2) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3 (zeige SPINK1 ELISA Kits)
IRF2 overexpression protects against I/R injury by decreasing IRF1 (zeige IRF1 ELISA Kits)-dependent injury and may represent a novel therapeutic strategy.
Data show that HCFC2 (zeige HCFC2 ELISA Kits) is a critical component of the IRF1 (zeige IRF1 ELISA Kits) and IRF2 transcriptional machinery that regulates Tlr3 (zeige TLR3 ELISA Kits) gene expression.
Mysm1 enhanced function of the IRF2 and IRF8 promoters, suggesting that Mysm1 governs the IRFs for hematopoietic stem cell homeostasis.
Interferon regulatory factor 2 protects mice from lethal viral neuroinvasion
Chimeric IRF-2 binds with IRF (zeige TRIM63 ELISA Kits)-E motif and VREbeta but not with VREalpha1.
IFN regulatory factor 2 (Irf2) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3 (zeige SPINK3 ELISA Kits)
These results revealed a multi-faceted role of IRF-2 in the function of B cells, particularly B2 cells, through regulating proliferation in an IFNAR (zeige IFNAR1 ELISA Kits)-dependent manner and antibody production via up-regulation of Blimp-1 (zeige PRDM1 ELISA Kits).
In mice doubly deficient forIRF-2 and CD1d (zeige CD1D ELISA Kits), the overall memory phenotype T cell population is contrastingly enlarged.
IRF2 regulates exocytosis in pancreatic acinar cells; defects in this process might be involved in the early phases of acute pancreatitis.
Forced expression of the interferon regulatory factor 2 oncoprotein causes polyploidy and cell death in FDC-P1 myeloid hematopoietic progenitor cells.
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.
regulatory factor 2
, interferon responsive factor 2
, interferon regulatory factor 2b