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ICAM4 encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. Zusätzlich bieten wir Ihnen ICAM4 Antikörper (72) und ICAM4 Kits (18) und viele weitere Produktgruppen zu diesem Protein an.
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Human ICAM4 Protein expressed in Human Cells - ABIN2005647
Bhalla, Chugh, Mehrotra, Rathore, Tousif, Prakash Dwivedi, Prakash, Kumar Samuchiwal, Kumar, Kumar Singh, Ghanwat, Kumar, Das, Mohmmed, Malhotra, Ranganathan: Host ICAMs play a role in cell invasion by Mycobacterium tuberculosis and Plasmodium falciparum. in Nature communications 2015
Cytometry analysis evidenced a specific expression profile on reticulocytes of SCA infants, with notably an increased expression of the adhesion molecules Lu/BCAM (zeige BCAM Proteine), ICAM-4 and LFA-3, both in percentage of positive cells and in surface density.
ICAM-1 (zeige ICAM1 Proteine) and ICAM-4 play roles in host cell invasion by M. tuberculosis and P. falciparum, respectively.
Seven variant ICAM4 alleles were found, distinct from the wild-type ICAM4 allele (GenBank KF712272), known as LW*05 and encoding LW(a) .
Data from differentiating cultured erythroid precursor cells suggest that RhAG (Rh-associated glycoprotein (zeige RHAG Proteine)) knockdown abolishes Rh blood group (zeige DARC Proteine) expression (ICAM4; RhoD [ras homolog family member D]; CD47 Rh-related antigen (zeige CD47 Proteine)) in erythroid cells.
Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium.
In a transgenic mouse model of sickle cell disease ICAM-4 is implicated in abnormal adhesiveness of erythrocytes to endothelium.
ICAM-4 as the first red blood cells protein ligand of platelets that may have relevant physiological significance
binds to the I domains of the CD11a (zeige ITGAL Proteine)/CD18 (zeige ITGB2 Proteine) and CD11b/CD18 (zeige ITGAM Proteine) leukocyte integrins
12 single amino-acid changes in ICAM4 affected the interaction of ICAM-4 with alpha(V) integrins
Different integrins bind to different but partly overlapping sites on ICAM4, and ICAM4 may accommodate multiple integrin receptors present on leukocytes, platelets and endothelial cells.
A novel second splice cDNA encodes an ICAM-4 isoform lacking the membrane-spanning domain. Erythroblasts express both isoforms. This new isoform, ICAM (zeige ICAM1 Proteine)-4S, may modulate membrane-associated ICAM-4 binding & regulate erythroblast molecular attachments.
ICAM-4 is critical in erythroblastic island formation via ICAM-4/alpha(V) adhesion
This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100\; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms.
, LW blood group protein
, Landsteiner-Wiener blood group antigen a
, Landsteiner-Wiener blood group glycoprotein
, intercellular adhesion molecule 4
, intercellular adhesion molecule 4 (LW blood group)
, Landsteiner-Wiener blood group protein
, intercellular adhesion molecule 4, Landsteiner-Wiener blood group
, LW glycoprotein