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Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. Zusätzlich bieten wir Ihnen Integral Membrane Protein 2B Antikörper (63) und Integral Membrane Protein 2B Proteine (19) und viele weitere Produktgruppen zu diesem Protein an.
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Familial British dementia (FBD) and familial Danish dementia (FDD) are caused by mutations in the BRI2 gene.
when BRI2 is phosphorylated a significant increase in neuronal outgrowth and differentiation is evident
Data depict roles for Bri2 and apolipoprotein E4 (ApoE4) proteins in a long-term memory regulation pathway. A single mutation in one Itm2b/Bri2 allele can affect both long-term and working memory, while ApoE4 seems to regulate short-term/working memory.
Cystine-linked oligomers of ABri are toxic to neurons and block long-term potentiation.
Data indicate integral membrane 2B (ITM2B) as a target of B-cell CLL/lymphoma 6 (zeige BCL6 ELISA Kits) protein (BCL6 (zeige BCL6 ELISA Kits)) repression in lymphoma.
Data indicate that the mutation originates the highly amyloidogenic molecule integral membrane protein 2B ABri.
This review support the hypothesis that BRI2 change during disease devel-opment, and thus may have a role in Alzheimer disease.
It binds amyloid precursor protein (zeige APP ELISA Kits) to halt amyloid-b production and inhibits amyloid-b aggregation via its BRICHOS-domain suggesting a link between BRI2 and Alzheimer's disease (AD)
Findings highlight pathogenic mechanism(s) associated with ITM2B mutations underlying dementia or retinal disease and add a new candidate to the list of genes involved in inherited retinal dystrophies.
Structural modeling of transmembrane (BRICHOS) domains of BRI2/ITM2B and SFTPC (zeige SFTPC ELISA Kits) (pulmonary surfactant protein C (zeige SFTPC ELISA Kits)) precursor identifies conserved region structurally complementary to beta-sheet/amyloid-prone region in BRICHOS domain-containing proteins.
Data indicate that double transgenic (Tg-FDD-Tau) mice showed a significant decrease in synaptophysin (zeige SYP ELISA Kits) levels.
BRI2 protein regulates beta-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE (zeige IDE ELISA Kits)).
Suggest that Adam7 (zeige ADAM7 ELISA Kits) functions in fertilization through the formation of a complex with heat shock protein 5 (zeige HSPA5 ELISA Kits), calnexin (zeige CANX ELISA Kits) and Itm2b during capacitation in sperm.
The shor form of ITM2B induces apoptosis in IL-2 (zeige IL2 ELISA Kits)-stimulated cells. The long form can't induce it. ITM2B(s) interacts with Bcl-2 (zeige BCL2 ELISA Kits), but not with Bad. Mutation of the L and D residues in the BH3 domain abolished the ability of ITM2B(s) to promote apoptosis.
ITM2B(S) induces apoptosis via a caspase (zeige CASP3 ELISA Kits)-dependent mitochondrial pathway.
BH3-only (zeige BBC3 ELISA Kits) protein ITM2Bs is able to induce apoptotic cell death in p53 (zeige TP53 ELISA Kits)+/+, as well as in p53 (zeige TP53 ELISA Kits)-/- cell lines.
Itm2b mRNA was differentially expressed in mouse male reproductive tissues, during sexual maturation and up-regulated by testosterone.
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
ABri/ADan amyloid peptide
, BRICHOS domain containing 2B
, immature BRI2
, transmembrane protein BRI
, Integral membrane protein 2B (E25B protein)
, integral membrane protein 2B
, putative transmembrane protein E3-16
, transmembrane protein E3-16
, BRICHOS-like protein
, integral membrane protein 2b