anti-Integral Membrane Protein 2B (ITM2B) Antikörper

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. Zusätzlich bieten wir Ihnen Integral Membrane Protein 2B Proteine (19) und Integral Membrane Protein 2B Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ITM2B 9445 Q9Y287
ITM2B 16432 O89051
ITM2B 290364 Q5XIE8
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Top anti-Integral Membrane Protein 2B Antikörper auf antikoerper-online.de

Showing 10 out of 63 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Huhn Unkonjugiert IHC (fro), WB Figure 1. Western Blot of various organs stained with anti BRI (ITM2B), N-terminal B6 mouse strain. 0.2 mg Anmelden zum Anzeigen 6 bis 8 Tage
$621.50
Details
Rind (Kuh) Ziege Unkonjugiert IHC (p), ELISA, WB Anti-ITM2B antibody IHC staining of human small intestine, myenteric plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN962664 concentration 41396 ug/ml. 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$451.00
Details
Human Ziege Unkonjugiert ELISA, WB Western Blot: ITM2B Antibody [NBP1-36963] - Analysis of ITM2B in Human Hippocampus lysate (35ug protein in RIPA buffer) using NBP1-36963 at 1 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$408.19
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: ITM2B Antibody [NBP2-17000] - Analysis of methanol-fixed HeLa, using antibody at 1:200 dilution. Western Blot: ITM2B Antibody [NBP2-17000] - 50 ug mouse brain lysate/extract 12% SDS-PAGE ITM2B antibody dilution: 1:1000. 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$447.56
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Western Blot: ITM2B Antibody [NBP1-88354] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY411840) Immunohistochemistry-Paraffin: ITM2B Antibody [NBP1-88354] - Staining of human duodenum shows strong cytoplasmic positivity with a granular pattern in glandular cells. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$439.69
Details
Human Maus Unkonjugiert FACS, IHC, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ITM2B (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-ITM2B. Flow cytometric Analysis of Hela cells, using anti-ITM2B antibody (ABIN2454457), (Red), compared to a nonspecific negative control antibody, (Blue). 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$482.90
Details
Human Huhn Unkonjugiert IHC (fro)   0.2 mg Anmelden zum Anzeigen 6 bis 8 Tage
$577.50
Details
Rind (Kuh) Ziege Unkonjugiert WB   0.1 mg Anmelden zum Anzeigen 12 bis 15 Tage
$375.38
Details
Human Ziege Unkonjugiert ELISA, WB 0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$481.25
Details
Human Huhn Unkonjugiert WB 0.05 mg Anmelden zum Anzeigen 2 bis 3 Tage
$412.50
Details

ITM2B Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Rat (Rattus)
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Am meisten referenzierte anti-Integral Membrane Protein 2B Antikörper

  1. Human Polyclonal ITM2B Primary Antibody für ELISA, WB - ABIN451809 : Majewski, Lee, Jeong, Yoon, Kram, Kim, Tuziak, Bondaruk, Lee, Park, Tang, Chung, Shen, Ahmed, Johnston, Grossman, Dinney, Zhou, Harris, Snyder, Filipek, Narod, Watson, Lynch, Gazdar, Bar-Eli, Wu et al.: Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy. ... in Laboratory investigation; a journal of technical methods and pathology 2008 (PubMed)

  2. Human Polyclonal ITM2B Primary Antibody für ICC, IF - ABIN4327783 : Baron, Baron, Baron: The ITM2B (BRI2) gene is a target of BCL6 repression: Implications for lymphomas and neurodegenerative diseases. in Biochimica et biophysica acta 2015 (PubMed)

Weitere Antikörper gegen Integral Membrane Protein 2B Interaktionspartner

Human Integral Membrane Protein 2B (ITM2B) Interaktionspartner

  1. Familial British dementia (FBD) and familial Danish dementia (FDD) are caused by mutations in the BRI2 gene.

  2. when BRI2 is phosphorylated a significant increase in neuronal outgrowth and differentiation is evident

  3. Data depict roles for Bri2 and apolipoprotein E4 (ApoE4) proteins in a long-term memory regulation pathway. A single mutation in one Itm2b/Bri2 allele can affect both long-term and working memory, while ApoE4 seems to regulate short-term/working memory.

  4. Cystine-linked oligomers of ABri are toxic to neurons and block long-term potentiation.

  5. Data indicate integral membrane 2B (ITM2B) as a target of B-cell CLL/lymphoma 6 (zeige BCL6 Antikörper) protein (BCL6 (zeige BCL6 Antikörper)) repression in lymphoma.

  6. Data indicate that the mutation originates the highly amyloidogenic molecule integral membrane protein 2B ABri.

  7. This review support the hypothesis that BRI2 change during disease devel-opment, and thus may have a role in Alzheimer disease.

  8. It binds amyloid precursor protein (zeige APP Antikörper) to halt amyloid-b production and inhibits amyloid-b aggregation via its BRICHOS-domain suggesting a link between BRI2 and Alzheimer's disease (AD)

  9. Findings highlight pathogenic mechanism(s) associated with ITM2B mutations underlying dementia or retinal disease and add a new candidate to the list of genes involved in inherited retinal dystrophies.

  10. Structural modeling of transmembrane (BRICHOS) domains of BRI2/ITM2B and SFTPC (zeige SFTPC Antikörper) (pulmonary surfactant protein C (zeige SFTPC Antikörper)) precursor identifies conserved region structurally complementary to beta-sheet/amyloid-prone region in BRICHOS domain-containing proteins.

Mouse (Murine) Integral Membrane Protein 2B (ITM2B) Interaktionspartner

  1. Data indicate that double transgenic (Tg-FDD-Tau) mice showed a significant decrease in synaptophysin (zeige SYP Antikörper) levels.

  2. BRI2 protein regulates beta-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE (zeige IDE Antikörper)).

  3. Suggest that Adam7 (zeige ADAM7 Antikörper) functions in fertilization through the formation of a complex with heat shock protein 5 (zeige HSPA5 Antikörper), calnexin (zeige CANX Antikörper) and Itm2b during capacitation in sperm.

  4. The shor form of ITM2B induces apoptosis in IL-2 (zeige IL2 Antikörper)-stimulated cells. The long form can't induce it. ITM2B(s) interacts with Bcl-2 (zeige BCL2 Antikörper), but not with Bad. Mutation of the L and D residues in the BH3 domain abolished the ability of ITM2B(s) to promote apoptosis.

  5. ITM2B(S) induces apoptosis via a caspase (zeige CASP3 Antikörper)-dependent mitochondrial pathway.

  6. BH3-only (zeige BBC3 Antikörper) protein ITM2Bs is able to induce apoptotic cell death in p53 (zeige TP53 Antikörper)+/+, as well as in p53 (zeige TP53 Antikörper)-/- cell lines.

  7. Itm2b mRNA was differentially expressed in mouse male reproductive tissues, during sexual maturation and up-regulated by testosterone.

Integral Membrane Protein 2B (ITM2B) Antigen-Profil

Protein Überblick

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

Genbezeichner und Symbole assoziert mit ITM2B

  • integral membrane protein 2B (ITM2B) Antikörper
  • integral membrane protein 2B (Itm2b) Antikörper
  • integral membrane protein 2Ba (itm2ba) Antikörper
  • integral membrane protein 2B L homeolog (itm2b.L) Antikörper
  • integral membrane protein 2B (itm2b) Antikörper
  • integral membrane protein 2b (itm2b) Antikörper
  • ABRI Antikörper
  • AI256040 Antikörper
  • Bri Antikörper
  • Bri2 Antikörper
  • Bricd2b Antikörper
  • D14Sel6 Antikörper
  • E3-16 Antikörper
  • E25B Antikörper
  • E25BMM Antikörper
  • FBD Antikörper
  • imBRI2 Antikörper
  • ITM2B Antikörper
  • MGC52745 Antikörper
  • MGC76131 Antikörper
  • wu:fc05f02 Antikörper
  • zgc:55770 Antikörper
  • zgc:85688 Antikörper

Bezeichner auf Proteinebene für ITM2B

ABri/ADan amyloid peptide , BRICHOS domain containing 2B , immature BRI2 , transmembrane protein BRI , Integral membrane protein 2B (E25B protein) , integral membrane protein 2B , putative transmembrane protein E3-16 , transmembrane protein E3-16 , BRICHOS-like protein , integral membrane protein 2b

GENE ID SPEZIES
9445 Homo sapiens
16432 Mus musculus
290364 Rattus norvegicus
323632 Danio rerio
380074 Xenopus laevis
394850 Xenopus (Silurana) tropicalis
395969 Gallus gallus
452714 Pan troglodytes
476916 Canis lupus familiaris
510575 Bos taurus
595120 Sus scrofa
100174988 Ovis aries
100528504 Ictalurus punctatus
100459693 Pongo abelii
100716017 Cavia porcellus
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