anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein (IKBKAP) Antikörper

The protein encoded by IKBKAP is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. Zusätzlich bieten wir Ihnen Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
IKBKAP 230233 Q7TT37
IKBKAP 8518 O95163
IKBKAP 140934 Q8VHU4
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Top anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein Antikörper auf antikoerper-online.de

Showing 10 out of 94 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Maus Unkonjugiert WB IKBKAP monoclonal antibody (M03), clone 6G9 Western Blot analysis of IKBKAP expression in HeLa on formalin-fixed paraffin-embedded human colon (antibody concentration 3 µg/mL). 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$450.00
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC (p), ELISA, WB Human Lung, Nerve (formalin-fixed, paraffin-embedded) stained with IKBKAP antibody ABIN214271 at 20 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$451.00
Details
Human Maus Unkonjugiert IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to IKBKAP on formalin-fixed paraffin-embedded human colon. [antibody concentration 3 ug/ml] IKBKAP monoclonal antibody (M03), clone 6G9 Western Blot analysis of IKBKAP expression in HeLa . 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$440.00
Details
Human Kaninchen Unkonjugiert ICC, IHC (p), WB Human Prostate (formalin-fixed, paraffin-embedded) stained with IKBKAP antibody ABIN214497 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Testis (formalin-fixed, paraffin-embedded) stained with IKBKAP antibody ABIN214497 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$451.00
Details
Hund Kaninchen Unkonjugiert WB   100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
$368.50
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Human Kaninchen Unkonjugiert EIA, IF, WB   0.1 mg Anmelden zum Anzeigen 12 bis 15 Tage
$469.32
Details
Human Maus Unkonjugiert ELISA, WB 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$537.17
Details
Human Kaninchen Unkonjugiert IF, IHC (p), WB 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
$368.50
Details
Human Kaninchen Unkonjugiert WB Western Blot: IKBKAP Antibody [ABIN153156] - Analysis of IKBKAP in Interleukin-1-stimulated 293 cells using this antibody at 1:500 dilution. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$415.44
Details

IKBKAP Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein Antikörper

  1. Human Polyclonal IKBKAP Primary Antibody für ICC, ELISA - ABIN1002511 : Krappmann, Hatada, Tegethoff, Li, Klippel, Giese, Baeuerle, Scheidereit: The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component. in The Journal of biological chemistry 2000 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal IKBKAP Primary Antibody für IHC (p), ELISA - ABIN563666 : Lefler, Cohen, Kantor, Cheishvili, Even, Birger, Turetsky, Gil, Even-Ram, Aizenman, Bashir, Maayan, Razin, Reubinoff, Weil: Familial Dysautonomia (FD) Human Embryonic Stem Cell Derived PNS Neurons Reveal that Synaptic Vesicular and Neuronal Transport Genes Are Directly or Indirectly Affected by IKBKAP Downregulation. in PLoS ONE 2015 (PubMed)

Weitere Antikörper gegen Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein Interaktionspartner

Arabidopsis thaliana Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein (IKBKAP) Interaktionspartner

  1. show that the Elongator (elo1, elo2, and elo3) complex was purified from plant cell cultures as a six-component complex.

  2. Elongator is important for plants to respond to ABA and drought exposure and that ABO1/ELO2 may play a vital role in ABA signal transduction pathways.[ABO1]

Mouse (Murine) Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein (IKBKAP) Interaktionspartner

  1. Results show that although Ikbkap is not required for normal development of retinal ganglion cells, its loss causes a slow, progressive retinal ganglion cells degeneration most severely in the temporal retina, which is later followed by indirect photoreceptor loss and complete retinal disorganization.

  2. Our results show that tissue-specific expression of RBM24 (zeige RBM24 Antikörper) can explain the neuron-specific aberrant splicing of IKBKAP exon 20 in familial dysautonomia, and that ectopic expression of RBM24 (zeige RBM24 Antikörper) in neuronal tissue could be a novel therapeutic target of the disease.

  3. ELP1 has a neuron autonomous role in sympathetic and sensory target tissue innervation

  4. Phosphatidylserine increases IKBKAP levels in a humanized knock-in IKBKAP mouse model for Familial dysautonomia.

  5. Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3 (zeige PAX3 Antikörper)+ progenitors and peripheral neurons.

  6. our study not only reveals a novel function of IKAP in meiosis, but also suggests that IKAP contributes to this process partly by exerting its effect on transcription and tRNA modification

  7. IKAP expression levels modulate disease severity in a mouse model of familial dysautonomia.

  8. IKAP is essential for expression of specific genes involved in cardiac morphogenesis (zeige XIRP1 Antikörper), and cardiac failure is the likely cause of abnormal vascular development and embryonic lethality; deletion of exon 20 abolishes gene function

  9. mutations in the human I-kappaB kinase-associated protein (IKBKAP) gene are responsible for familial dysautonomia (FD).no animal model of FD currently exists, cloning of the mouse Ikbkap gene is an important step toward creating a mouse model for FD

  10. description of a humanized IKBKAP transgenic mouse that models a tissue-specific human splicing defect

Human Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein (IKBKAP) Interaktionspartner

  1. overexpression of miR (zeige MLXIP Antikörper)-203a-3p leads to a decrease of NOVA1 (zeige NOVA1 Antikörper), counter-balanced by an increase of IKAP, supporting a potential interaction between NOVA1 (zeige NOVA1 Antikörper) and IKAP.

  2. IKAP might be a vesicular like protein that might be involved in neuronal transport in hESC derived PNS neurons

  3. The formation of the Elp1 dimer contributes to its stability in vitro and in vivo and is required for the assembly of human Elongator complexes.

  4. IKBKAP mRNA levels decreased during a familial dysautonomia crisis and returned to baseline after recovery. The cause-and-effect relationship is unclear.

  5. Phosphatidylserine increases IKBKAP levels in a humanized knock-in IKBKAP mouse model for Familial dysautonomia.

  6. Digoxin-mediated repression of SRSF3 (zeige SRSF3 Antikörper) expression plays a role in the digoxin-mediated inclusion of exon 20 in the IKBKAP transcript generated from the familial dysautonomia mutant allele.

  7. Combined treatment with epigallocatechin gallate and genistein synergistically upregulates wild-type IKBKAP-encoded RNA and protein levels in familial dysautonomia-derived cells.

  8. IKAP plays pleiotropic roles in both the peripheral and central nervous systems

  9. IKAP/hELP1 deficiency has an effect on gene expression in differentiating neuroblastoma (zeige ARHGEF16 Antikörper) cells, and possibly on familial dysautonomia

  10. IKK complex-associated protein deficiency upregulates the microtubule destabilizing protein SCG10 (zeige STMN2 Antikörper) and, in parallel, disorganizes the cytoskeleton

Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein (IKBKAP) Antigen-Profil

Protein Überblick

The protein encoded by this gene is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. This encoded protein can bind NF-kappa-B-inducing kinase (NIK) and IKKs through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia.

Genbezeichner und Symbole assoziert mit IKBKAP

  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein (IKBKAP) Antikörper
  • elongator complex protein 1 (ELP1) Antikörper
  • elongator complex protein 1 (elp1) Antikörper
  • IKI3 family protein (ABO1) Antikörper
  • inhibitor of kappa light polypeptide enhancer in B cells, kinase complex-associated protein (Ikbkap) Antikörper
  • elongator complex protein 1 (Elp1) Antikörper
  • ielongator complex protein 1 S homeolog (elp1.S) Antikörper
  • 3110040G09Rik Antikörper
  • 6030413P05 Antikörper
  • ABA-OVERLY SENSITIVE 1 Antikörper
  • C78473 Antikörper
  • DKFZp469N1415 Antikörper
  • DYS Antikörper
  • ELO2 Antikörper
  • ELONGATA 2 Antikörper
  • ELP1 Antikörper
  • FD Antikörper
  • IKAP Antikörper
  • IKBKAP Antikörper
  • IKI3 Antikörper
  • MSH12.15 Antikörper
  • MSH12_15 Antikörper
  • TOT1 Antikörper

Bezeichner auf Proteinebene für IKBKAP

elongator complex protein 1 , inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein , IKK complex-associated protein , IKK-complex-associated protein IKAP , ikappaB kinase complex-associated protein , inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein , elongator acetyltransferase complex subunit 1 , p150 , ELP1 , IKAP , putative elongator complex protein 1

GENE ID SPEZIES
427375 Gallus gallus
473014 Pan troglodytes
612455 Canis lupus familiaris
100170442 Xenopus (Silurana) tropicalis
100171912 Pongo abelii
100229335 Taeniopygia guttata
100560669 Anolis carolinensis
100585002 Nomascus leucogenys
831213 Arabidopsis thaliana
230233 Mus musculus
8518 Homo sapiens
140934 Rattus norvegicus
100009360 Oryctolagus cuniculus
735009 Xenopus laevis
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