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Indoleamine 2,3-Dioxygenase 2 Proteine (IDO2)

Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011].. Zusätzlich bieten wir Ihnen IDO2 Antikörper (120) und IDO2 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
IDO2 169355 Q6ZQW0
IDO2 681319  
IDO2 209176  
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Showing 8 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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HOST_Escherichia coli (E. coli) Human His tag 10 μg Anmelden zum Anzeigen 18 bis 20 Tage
287,50 €
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HOST_Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
640,00 €
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HOST_Escherichia coli (E. coli) Ratte His tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
571,43 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Escherichia coli (E. coli) Ratte Unkonjugiert   100 μg Anmelden zum Anzeigen 7 bis 14 Tage
674,40 €
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HOST_Escherichia coli (E. coli) Maus Unkonjugiert   100 μg Anmelden zum Anzeigen 7 bis 14 Tage
818,45 €
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IDO2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Rat (Rattus)

Mouse (Murine) ,

Weitere Proteine zu Indoleamine 2,3-Dioxygenase 2 (IDO2) Interaktionspartnern

Human Indoleamine 2,3-Dioxygenase 2 (IDO2) Interaktionspartner

  1. High IDO2 expression is associated with Colorectal Cancer.

  2. High IDO2 expression is associated with cervical cancer.

  3. functional importance of IDO (zeige IDO1 Proteine) enzymes in human Crohn's disease

  4. Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1 (zeige IDO1 Proteine)

  5. These results demonstrate that IDO2 plays a novel role as a negative regulator of IDO1 (zeige IDO1 Proteine) by competing for heme-binding with IDO1 (zeige IDO1 Proteine).

  6. The IDO2 is now known to catalyze the first and rate-limiting step in the catabolism of tryptophan along a relative newcomer to the kynurenine pathway field.

  7. Multiple-scattering (MS) analysis of EXAFS data on met-indoleamine 2,3-dioxygenase-2 (IDO2) and analysis of XANES have provided the first direct structural information about the axial donor ligands of the iron center for this recently discovered protein.

  8. IDO2 is expressed in both mDCs and plasmacytoid DCs and is not modulated by PGE2. IDO2 expression is constitutively, stably expressed in steady-state conditions and may contribute to the homeostatic tolerogenic capacity of DCs.

  9. Indoleamine2,3-dioxygenase and tryptophanyl-tRNA synthetase (zeige WARS Proteine) may play critical roles in the immune pathogenesis of chronic kidney disease.

  10. Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 (zeige IDO1 Proteine) and IDO2) and discovery of selective IDO1 (zeige IDO1 Proteine) inhibitors.

Mouse (Murine) Indoleamine 2,3-Dioxygenase 2 (IDO2) Interaktionspartner

  1. Indoleamine-2,3-dioxygenase (IDO (zeige IDO1 Proteine)) production by Plasmacytoid dendritic cells (pDCs)is necessary to confer suppressive function to T-Cells, Regulatory (Tregs) in experimental autoimmune encephalomyelitis (EAE).

  2. Ido2 may be important for mouse embryo implantation and decidualization.

  3. The data showed that there is not significant effect of IDO1 (zeige IDO1 Proteine) or TDO2 (zeige TDO2 Proteine) on mortality in pneumococcal meningitis.

  4. IDO2 is critical for IDO1 (zeige IDO1 Proteine)-mediated T-cell regulation and exerts a non-redundant function in inflammation.

  5. Deletion of Ido1 (zeige IDO1 Proteine) and reduced mRNA expression for Ido2 neither affected the concentration of the downstream metabolites of tryptophan nor mRNA expression for downstream genes on the kynurenine pathway in inguinal lymph nodes.

  6. results provide important insights into IDO2 function by defining its pathogenic contributions to autoantibody-mediated autoimmunity.

  7. Immunohistochemical analysis in Ido1 (zeige IDO1 Proteine)(-/-) mouse epididymis showed that Ido2 protein was extensively upregulated due to the loss of Ido1 (zeige IDO1 Proteine) expression.

  8. IDO-1 (zeige IDO1 Proteine) and IDO-2 play biologically important, contradictory roles during intracellular protozoal infection - facilitating (Toxoplasma gondii) or suppressing (Leishmania major) microbial clearance in a pathogen-specific manner.

  9. Findings implicate novel IDO (zeige IDO1 Proteine) related enzyme IDO2 in cancer as a result of its preferential inhibition by the D racemer of 1-methyl-tryptophan, used widely in its racemic form (D,L-1MT) as an IDO (zeige IDO1 Proteine) inhibitor including as an anticancer agent

  10. A second tryptophan catabolic enzyme inducible by IFNg (zeige IFNG Proteine), implicated in transcriptional immune regulation (IFNg (zeige IFNG Proteine)-driven negative feedback), may limit the pro-inflammatory and anti-proliferative functions(Review)

IDO2 Protein Überblick

Protein Überblick

Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007

Genbezeichner und Symbole assoziert mit IDO2

  • indoleamine 2,3-dioxygenase 2 (IDO2)
  • indoleamine 2,3-dioxygenase 2 (Ido2)
  • AI265623 Protein
  • C230043N17Rik Protein
  • Ido-2 Protein
  • Indol1 Protein

Bezeichner auf Proteinebene für IDO2

indoleamine 2,3-dioxygenase 2 , indoleamine 2,3-dioxygenase 2-like , IDO-2 , indoleamine 2,3-dioxygenase-like 1 protein , indoleamine 2,3-dioxygenase-like protein 1 , indoleamine-pyrrole 2,3 dioxygenase-like 1 , indoleamine-pyrrole 2,3-dioxygenase-like protein 1

GENE ID SPEZIES
100402049 Callithrix jacchus
707424 Macaca mulatta
100085939 Ornithorhynchus anatinus
100435160 Pongo abelii
100480334 Ailuropoda melanoleuca
100580956 Nomascus leucogenys
169355 Homo sapiens
482846 Canis lupus familiaris
513810 Bos taurus
681319 Rattus norvegicus
209176 Mus musculus
100056686 Equus caballus
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