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The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. Zusätzlich bieten wir Ihnen Importin 8 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal Importin 8 Primary Antibody für ICC, IF - ABIN4325788
Wu, Wang, Young, Lai, Li: Proteome-wide identification of novel binding partners to the oncogenic fusion gene protein, NPM-ALK, using tandem affinity purification and mass spectrometry. in The American journal of pathology 2009
Show all 2 Pubmed References
Human Polyclonal Importin 8 Primary Antibody für IHC (p), IHC - ABIN249599
Görlich, Dabrowski, Bischoff, Kutay, Bork, Hartmann, Prehn, Izaurralde: A novel class of RanGTP binding proteins. in The Journal of cell biology 1997
the findings of the present study provided novel insights into the control of IPO8 transcription, and may enhance understanding regarding RUNX2 (zeige RUNX2 Antikörper) regulatory mechanisms in osteoblast differentiation, bone development, and degenerative bone disease.
Our studies also suggest that nuclear entry is important for the prooncogenic activity of eIF4E (zeige EIF4E Antikörper), at least in this context. These findings position nuclear trafficking of eIF4E (zeige EIF4E Antikörper) as a critical step in its regulation and position the importin 8-eIF4E (zeige EIF4E Antikörper) complex as a novel therapeutic target.
importin alpha8 functions as a cNLS receptor with distinct cargo specificity, and that heterodimerization by importin alpha8 is a novel regulatory mode of cNLS binding, in addition to the autoinhibitory regulation by the importin beta (zeige KPNB1 Antikörper) binding domain.
Knockdown of IPO8 reduced the amount of nuclear p65 (zeige GORASP1 Antikörper) following TNF (zeige TNF Antikörper) stimulation. IPO8 binding to p65 (zeige GORASP1 Antikörper) is NLS (zeige ALDH1A2 Antikörper) independent.
TGF-beta (zeige TGFB1 Antikörper)-induced and basal state spontaneous nuclear import of Smad4 (zeige SMAD4 Antikörper) require importin 7 (zeige IPO7 Antikörper) and 8.
IPO8 is the most accurate reference gene for clinical lung specimens.
Study provides evidence that Imp8 is required for cytoplasmic miRNA-guided gene silencing and affects nuclear localization of Ago proteins.
Importin 8 plays a critical role in mediating the cytoplasm-to-nucleus transport of mature miRNAs. IPO8-mediated nuclear transport of mature miRNAs is also dependent on the association of IPO8 with the Argonaute 2 (zeige EIF2C2 Antikörper) complex.
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, RAN binding protein 8
, ran-binding protein 8
, ATP-binding cassette, sub-family C (CFTR/MRP), member 10
, oocyte maturation 1