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Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Zusätzlich bieten wir Ihnen Immunoglobulin Associated alpha Antikörper (4) und viele weitere Produktgruppen zu diesem Protein an.
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BCR (zeige BCR Proteine) activation is accompanied by asymmetric conformational changes, possibly promoting the binding of Igalpha and Igbeta to differently localized signaling complexes
CD79a (zeige CD79A Proteine) myeloid cells showed enhanced ability to promote primary tumor growth and metastasis.
Data indicate that in the absence of DGKzeta (zeige DGKZ Proteine), the threshold for B cell antigen receptor (BCR (zeige BCR Proteine)) signaling, measured as activation of the Ras-extracellular signal-regulated kinase (ERK (zeige EPHB2 Proteine)) pathway, was markedly reduced in mature follicular B cells.
Data show that the B cell antigen receptor (BCR (zeige BCR Proteine)) and Igalpha may be required for B cell survival because they function as adaptor proteins in a BAFFR (zeige TNFRSF13C Proteine) signaling pathway leading to activation of Syk (zeige SYK Proteine), indicating crosstalk between the two receptors.
The mouse B cell-specific mb-1 (zeige PSMB5 Proteine) gene encodes an immunoreceptor tyrosine-based activation motif (ITAM) protein that may be evolutionarily conserved in diverse species by purifying selection.
endocytosed BCR (zeige BCR Proteine) sequentially regulates MAPK (zeige MAPK1 Proteine) and Akt (zeige AKT1 Proteine) signaling pathways from intracellular compartments
Arginine 198 in the tail of the Igalpha subunit of the BCR (zeige BCR Proteine) is methylated by the protein arginine methyltransferase 1 (zeige PRMT1 Proteine). Methylation negatively regulates the calcium and PI-3 (zeige PI3 Proteine) kinase pathways of the BCR (zeige BCR Proteine), promoting signals leading to B (zeige TDO2 Proteine) cell differentiation.
The direct recruitment of BLNK (zeige BLNK Proteine) to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways
IgA deficiency in lymphotoxin-deficient (LT(-/-)) mice could be fully reversed by reconstitution with LT-expressing bone marrow, despite the absence of both LNs and PPs.
The VHDJH recombination process at the IgH locus and the survival of pro-B cells that carry these rearrangements do not depend on the expression of Ig-alpha molecules.
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
B-cell antigen receptor complex-associated protein alpha chain
, Ig alpha
, MB-1 membrane glycoprotein
, immunoglobulin-associated alpha
, membrane-bound immunoglobulin-associated protein
, surface IgM-associated protein