anti-Immunity-Related GTPase Family, M (IRGM) Antikörper

IRGM encodes a member of the p47 immunity-related GTPase family. Zusätzlich bieten wir Ihnen Immunity-Related GTPase Family, M Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
IRGM 15944 Q60766
IRGM 345611 A1A4Y4
IRGM 303090 Q6AYC2
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Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC (p), WB IRGM Antibody (C-term) (ABIN655080) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
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Maus Maus Unkonjugiert WB Mouse Irgm1  western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the IRGM1 antibody detected the Irgm1 protein (arrow). 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
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Human Kaninchen Unkonjugiert EIA, WB   0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
357,50 €
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Human Kaninchen Unkonjugiert EIA, IHC (p), WB   0.1 mg Anmelden zum Anzeigen 21 bis 26 Tage
357,50 €
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Human Kaninchen Unkonjugiert IHC (p), ELISA, WB Human Colon (formalin-fixed, paraffin-embedded) stained with IRGM antibody ABIN351455 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
501,70 €
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Human Kaninchen Unkonjugiert EIA, IHC (fro), IHC (p), WB IHC Image for AP22614PU-N Human Colon (formalin-fixed, paraffin-embedded) stained with IRGMat 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody LS-D1, alkaline phosphatase-streptavidin and chromogen. WB Image for AP22614PU-N Western blot analysis of IRGM in human brain lysate with IRGM antibody at (A) 1 and (B) 2 µg/ml. 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
517,00 €
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Human Kaninchen Unkonjugiert ELISA, WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
635,55 €
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Maus Maus Unkonjugiert WB Mouse Irgm1 Antibody  western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the IRGM1 antibody detected the IRGM1 protein (arrow). 0.1 mL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert ELISA, ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: IRGM Antibody [NBP1-76890] - Human brain with IRGM antibody at 5 ug/ml. Western Blot: IRGM Antibody [NBP1-76890] - Analysis in human brain lysate with antibody at (A) 1 and (B) 2 ug/mL. 0.1 mg Anmelden zum Anzeigen 3 bis 6 Tage
341,00 €
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Human Kaninchen Unkonjugiert IHC (p), IHC, ELISA, WB 50 μg Anmelden zum Anzeigen 8 bis 10 Tage
456,00 €
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IRGM Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Weitere Antikörper gegen Immunity-Related GTPase Family, M Interaktionspartner

Mouse (Murine) Immunity-Related GTPase Family, M (IRGM) Interaktionspartner

  1. M1 macrophage may promote Th1 (zeige HAND1 Antikörper)/Th17 cell differentiation during the early experimental autoimmune encephalomyelitis, and the proinflammatory function of M1 cells requires Irgm1.

  2. A series of metabolic studies indicated that the enhanced cytokine production was associated with marked metabolic changes in the Irgm1-deficient macrophages, including increased glycolysis and an accumulation of long chain acylcarnitines.

  3. data suggested that the deficiency of LRG-47 might affect host's CD4 (zeige CD4 Antikörper)(+) T cell immune response via the weakening of IFN-gamma (zeige IFNG Antikörper) downstream signaling

  4. Irgm1-/- embryonic fibroblasts show autophagic flux impairment and defective lysosomal degradation.

  5. Interestingly, we observed that IRGM1 enhanced F-actin polymerization and triggers epithelial mesenchymal transition (EMT) through a mechanism involved in PIK3CA mediated Rac1 activation.

  6. Interferon-beta (zeige IFNB1 Antikörper) activation recruited the immunity-related GTPase (zeige RACGAP1 Antikörper) M1 (IRGM1) to the Toxoplasma gondii-occupied parasitophorous vacuole in peritoneal macrophages and murine embryonic fibroblasts.

  7. these data reveal an Irgm1-dependent mechanism that promotes the tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1 (zeige SH3GLB1 Antikörper)-dependent autophagy

  8. Palmitoylation together with the alphaK helix firmly anchor Irgm1 in the Golgi and mitochondria, thus facilitating function of the protein.

  9. 2 Irgm1 isoforms generated by differential splicing localize to the Golgi apparatus & weakly to mitochondria. Only the long isoforms is seen on endolysosomal membranes. Irgm1 is a negative regulator of the immunity-related GTPase (zeige RACGAP1 Antikörper) protein family.

  10. the paralogous IRGM proteins Irgm1 and Irgm3 fail to robustly associate with "non-self" PVs (zeige PVRL2 Antikörper) containing either the bacterial pathogen Chlamydia trachomatis or the protozoan pathogen Toxoplasma gondii

Human Immunity-Related GTPase Family, M (IRGM) Interaktionspartner

  1. IRGM rs10065172 was associated with decreased risk of tuberculosis in Asian populations, but not in African/Africa-Americans. rs4958842, rs4859843, and rs4859846, had a large protective effect in Asians, whereas rs72553867 was not associated with tuberculosis risk.

  2. Polymorphisms of IRGM gene is associated with susceptibility to ankylosing spondylitis.

  3. IRGM polymorphism differences between latent and active TB suggests that genetic differences in autophagy might partly affect host TB infection status.

  4. IRGM functional polymorphisms and haplotypes in promoter were associated with the susceptibility to pulmonary tuberculosis in Chinese Hubei Han population.

  5. In Korean children, IRGM rs1000113 and IRGM rs72553867 exhibited associations with early-onset Crohn Disease as risk loci and defense loci, respectively.

  6. The study confirms IRGM rs13361189 and rs4958847 polymorphisms to be important for Crohn's disease susceptibility and phenotype modulation, in accordance with previous findings.

  7. Expression of viral protein 2C enhanced IRGM promoter activation, thereby increasing IRGM expression and inducing autophagy.

  8. these data reveal an Irgm1-dependent mechanism that promotes the tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1 (zeige ZBTB24 Antikörper)-dependent autophagy

  9. the IRGM(+313), an autophagy-related polymorphic locus, influences outcome in severely septic patients, with the possible involvement of autophagy in sepsis exacerbation

  10. Results show association of IRGM gene SNPs with Crohn's disease in Indian patients and report a new mutation rs 9637876 in the IRGM gene associated with Crohn's disease.

Immunity-Related GTPase Family, M (IRGM) Antigen-Profil

Protein Überblick

This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.

Genbezeichner und Symbole assoziert mit IRGM

  • immunity-related GTPase family, M (IRGM) Antikörper
  • immunity-related GTPase family M member 1 (Irgm1) Antikörper
  • immunity-related GTPase family, M (Irgm) Antikörper
  • IFI1 Antikörper
  • Iigp3 Antikörper
  • Iipg3 Antikörper
  • Irgm Antikörper
  • IRGM1 Antikörper
  • LRG-47 Antikörper
  • LRG47 Antikörper

Bezeichner auf Proteinebene für IRGM

immunity-related GTPase family M protein , immunity-related GTPase M , immunity-related GTPase family, M , LPS-stimulated RAW 264.7 macrophage protein 47 , immunity-related GTPase family M protein 1 , interferon inducible protein 1 , interferon-inducible GTPase 3 , interferon-inducible protein 1 , LPS-stimulated RAW 264.7 macrophage protein 47 homolog , LRG-47-like protein , immunity-related GTPase family, M1

GENE ID SPEZIES
471699 Pan troglodytes
481473 Canis lupus familiaris
15944 Mus musculus
345611 Homo sapiens
606863 Canis lupus familiaris
303090 Rattus norvegicus
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