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IRGM encodes a member of the p47 immunity-related GTPase family. Zusätzlich bieten wir Ihnen Immunity-Related GTPase Family, M Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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M1 macrophage may promote Th1 (zeige HAND1 Antikörper)/Th17 cell differentiation during the early experimental autoimmune encephalomyelitis, and the proinflammatory function of M1 cells requires Irgm1.
A series of metabolic studies indicated that the enhanced cytokine production was associated with marked metabolic changes in the Irgm1-deficient macrophages, including increased glycolysis and an accumulation of long chain acylcarnitines.
data suggested that the deficiency of LRG-47 might affect host's CD4 (zeige CD4 Antikörper)(+) T cell immune response via the weakening of IFN-gamma (zeige IFNG Antikörper) downstream signaling
Irgm1-/- embryonic fibroblasts show autophagic flux impairment and defective lysosomal degradation.
Interestingly, we observed that IRGM1 enhanced F-actin polymerization and triggers epithelial mesenchymal transition (EMT) through a mechanism involved in PIK3CA mediated Rac1 activation.
Interferon-beta (zeige IFNB1 Antikörper) activation recruited the immunity-related GTPase (zeige RACGAP1 Antikörper) M1 (IRGM1) to the Toxoplasma gondii-occupied parasitophorous vacuole in peritoneal macrophages and murine embryonic fibroblasts.
these data reveal an Irgm1-dependent mechanism that promotes the tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1 (zeige SH3GLB1 Antikörper)-dependent autophagy
Palmitoylation together with the alphaK helix firmly anchor Irgm1 in the Golgi and mitochondria, thus facilitating function of the protein.
2 Irgm1 isoforms generated by differential splicing localize to the Golgi apparatus & weakly to mitochondria. Only the long isoforms is seen on endolysosomal membranes. Irgm1 is a negative regulator of the immunity-related GTPase (zeige RACGAP1 Antikörper) protein family.
the paralogous IRGM proteins Irgm1 and Irgm3 fail to robustly associate with "non-self" PVs (zeige PVRL2 Antikörper) containing either the bacterial pathogen Chlamydia trachomatis or the protozoan pathogen Toxoplasma gondii
IRGM rs10065172 was associated with decreased risk of tuberculosis in Asian populations, but not in African/Africa-Americans. rs4958842, rs4859843, and rs4859846, had a large protective effect in Asians, whereas rs72553867 was not associated with tuberculosis risk.
Polymorphisms of IRGM gene is associated with susceptibility to ankylosing spondylitis.
IRGM polymorphism differences between latent and active TB suggests that genetic differences in autophagy might partly affect host TB infection status.
IRGM functional polymorphisms and haplotypes in promoter were associated with the susceptibility to pulmonary tuberculosis in Chinese Hubei Han population.
In Korean children, IRGM rs1000113 and IRGM rs72553867 exhibited associations with early-onset Crohn Disease as risk loci and defense loci, respectively.
The study confirms IRGM rs13361189 and rs4958847 polymorphisms to be important for Crohn's disease susceptibility and phenotype modulation, in accordance with previous findings.
Expression of viral protein 2C enhanced IRGM promoter activation, thereby increasing IRGM expression and inducing autophagy.
these data reveal an Irgm1-dependent mechanism that promotes the tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1 (zeige ZBTB24 Antikörper)-dependent autophagy
the IRGM(+313), an autophagy-related polymorphic locus, influences outcome in severely septic patients, with the possible involvement of autophagy in sepsis exacerbation
Results show association of IRGM gene SNPs with Crohn's disease in Indian patients and report a new mutation rs 9637876 in the IRGM gene associated with Crohn's disease.
This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.
immunity-related GTPase family M protein
, immunity-related GTPase M
, immunity-related GTPase family, M
, LPS-stimulated RAW 264.7 macrophage protein 47
, immunity-related GTPase family M protein 1
, interferon inducible protein 1
, interferon-inducible GTPase 3
, interferon-inducible protein 1
, LPS-stimulated RAW 264.7 macrophage protein 47 homolog
, LRG-47-like protein
, immunity-related GTPase family, M1