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anti-Huntingtin Associated Protein 1 (HAP1) Antikörper

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. Zusätzlich bieten wir Ihnen HAP1 Proteine (6) und HAP1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
HAP1 11792 P28352
HAP1 9001 P54257
HAP1 29430 P54256
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Top anti-HAP1 Antikörper auf antikoerper-online.de

Showing 10 out of 85 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Maus Ziege Unkonjugiert EIA, WB AP23773PU-N HAP-1 antibody staining of Mouse Brain lysate at 0.1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Anmelden zum Anzeigen 8 bis 10 Tage
385,00 €
Details
Human Maus Unkonjugiert ICC, FACS, IHC (fro), IF, IHC (p), IP, IHC, WB Staining of rat hypothalamus using ABIN259097. Detection of HAP1 in mouse brain lysate using ABIN259097. 0.1 mL Anmelden zum Anzeigen 2 bis 4 Tage
291,00 €
Details
Human Ziege Unkonjugiert ELISA, WB ABIN334416 (0.1µg/ml) staining of Human Brain (Hippocampus) lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Anmelden zum Anzeigen 3 bis 4 Tage
349,82 €
Details
Maus Maus Unkonjugiert IF, WB Western blot analysis of HAP1 on a rat cerebrum lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the anti- HAP1 antibody. Immunoflourescence staining of PC12 cells (rat neuroblastoma, ATCC CRL 1721). 50 μg Anmelden zum Anzeigen 2 bis 4 Tage
146,73 €
Details
Human Ziege Unkonjugiert ELISA, WB ABIN188689 (0.1?g/ml) staining of Human Brain (Hippocampus) lysate (35?g protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Western Blot: HAP1 Antibody [ABIN1886893] - Analysis of HAP1 in human brain (Hippocampus) lysate using this antibody at 0.1 ug/ml. 0.1 mg Anmelden zum Anzeigen 2 bis 4 Tage
311,00 €
Details
Maus Ziege Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 3 bis 4 Tage
349,82 €
Details
Human Kaninchen Unkonjugiert EIA, IHC (p) 50 μg Anmelden zum Anzeigen 8 bis 10 Tage
517,00 €
Details
Human Ziege Unkonjugiert EIA, WB 0.1 mg Anmelden zum Anzeigen 8 bis 10 Tage
357,50 €
Details
Human Ziege Unkonjugiert IHC (p), ELISA, WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
501,70 €
Details
Human Ziege Unkonjugiert ELISA, WB 0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
505,48 €
Details

HAP1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-HAP1 Antikörper

  1. Human Monoclonal HAP1 Primary Antibody für ICC, FACS - ABIN259097 : Chan, Nasir, Gutekunst, Coleman, Maclean, Maas, Metzler, Gertsenstein, Ross, Nagy, Hayden: Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior. in Human molecular genetics 2002 (PubMed)
    Zeige alle 7 Referenzen für ABIN259097

  2. Mouse (Murine) Monoclonal HAP1 Primary Antibody für IF, WB - ABIN968461 : Gutekunst, Li, Yi, Ferrante, Li, Hersch: The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1998 (PubMed)
    Zeige alle 5 Referenzen für ABIN968461

  3. Mouse (Murine) Polyclonal HAP1 Primary Antibody für EIA, WB - ABIN615992 : Rong, McGuire, Fang, Sheng, Shin, Li, Li: Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 (PubMed)
    Zeige alle 2 Referenzen für ABIN615992

  4. Human Polyclonal HAP1 Primary Antibody für ELISA, WB - ABIN188689 : Takeshita, Fujinaga, Zhao, Yanai, Shinoda: Huntingtin-associated protein 1 (HAP1) interacts with androgen receptor (AR) and suppresses SBMA-mutant-AR-induced apoptosis. in Human molecular genetics 2006 (PubMed)

Weitere Antikörper gegen HAP1 Interaktionspartner

Mouse (Murine) Huntingtin Associated Protein 1 (HAP1) Interaktionspartner

  1. HAP1 co-localizes with synapsin I (zeige SYN1 Antikörper) in cortical neurons as discrete puncta

  2. Suppression of Ape1/Ref-1 (zeige APEX1 Antikörper) redox function leads to an increased cell surface retention of IL-12 (zeige IL12A Antikörper) and enhances Th1 (zeige HAND1 Antikörper) responses.

  3. findings suggest that Hap1 is important for insulin (zeige INS Antikörper) secretion of pancreatic beta-cells via regulating the intracellular trafficking and plasma membrane localization of Cav1.2 (zeige CACNA1C Antikörper), providing new insight into the mechanisms that regulate insulin (zeige INS Antikörper) release from pancreatic beta-cells.

  4. Is closely associated with upregulation of the Ref1 (zeige THOC4 Antikörper)/Nrf2 (zeige NFE2L2 Antikörper) signalling pathway.

  5. Results show the stimulatory effect of PARP-1 (zeige PARP1 Antikörper) on APE1 (zeige APEX1 Antikörper)-dependent base excision repair (BER). PARP-1 (zeige PARP1 Antikörper) and APE1 (zeige APEX1 Antikörper) appear to have a functional interaction in BER since PARP-1 (zeige PARP1 Antikörper) can stimulate the strand incision activity of APE1 (zeige APEX1 Antikörper).

  6. Early loss of Hap1 significantly reduces postnatal hippocampal neurogenesis, and leads to adult depressive-like behavior.

  7. Hap1 interacts with Bcr (zeige BCR Antikörper) on microtubules to regulate neuronal differentiation.

  8. increases in APEX1 (zeige APEX1 Antikörper) level confer protection against the murine paternal age effect, thus highlighting the role of APEX1 (zeige APEX1 Antikörper) in preserving reproductive health with increasing age and in protection against genotoxin-induced mutagenesis in somatic cells

  9. Endothelial cell tumor proliferation was found to be dependent on Apex-1 (zeige APEX1 Antikörper) expression.

  10. Expression of OGG1 (zeige OGG1 Antikörper) and APEX1 (zeige APEX1 Antikörper) was decreased at 3h after last exposure to Aroclor 1254 and only the expression level of APEX1 (zeige APEX1 Antikörper) was recovered at 24-h after, so inhibition of DNA repair can be a potential mode of action of Aroclor 1254 gonadal toxicity.

Human Huntingtin Associated Protein 1 (HAP1) Interaktionspartner

  1. data fully support that HAP1 (zeige APEX1 Antikörper) is a GKAP (zeige DLGAP1 Antikörper), anchoring specifically to the cGMP-dependent protein kinase (zeige CDK7 Antikörper) isoform Ibeta, and provide further evidence that also PKG (zeige PRKG1 Antikörper) spatiotemporal signaling is largely controlled by anchoring proteins

  2. HAP1 (zeige APEX1 Antikörper) gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity

  3. Overexpression of HAP1 (zeige APEX1 Antikörper) reduced in vitro cell growth in breast cancer cell lines.

  4. The results of this study found no association was found between the HAP1 (zeige APEX1 Antikörper) T441M polymorphism and the age at onset of Huntington's disease .

  5. The results of this study suggested that HAP1 (zeige APEX1 Antikörper) co-localizes and associates with APP (zeige APP Antikörper) in physiological conditions of mouse and human brain.

  6. WT HTT (zeige HTT Antikörper) regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1 (zeige PCM1 Antikörper)).

  7. HAP1 (zeige APEX1 Antikörper)/stigmoid body interacts with the normal ataxin-3 (zeige ATXN3 Antikörper) through Josephin (zeige ATXN3 Antikörper) domain

  8. sortilin (zeige SORT1 Antikörper) stabilizes the proBDNF.HAP1 complex

  9. ADORA2A (zeige ADORA2A Antikörper), but not HAP1 (zeige APEX1 Antikörper) or OGG1 (zeige OGG1 Antikörper), may have a role in age at onset in Huntington's disease

  10. REVIEW: function of HAP1 (zeige APEX1 Antikörper)

HAP1 Antigen-Profil

Protein Überblick

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit HAP1

  • apurinic/apyrimidinic endonuclease 1 (Apex1) Antikörper
  • huntingtin-associated protein 1 (HAP1) Antikörper
  • huntingtin-associated protein 1 (Hap1) Antikörper
  • APE Antikörper
  • Apex Antikörper
  • HAP-1 Antikörper
  • HAP1 Antikörper
  • HAP1-A Antikörper
  • HAP1-B Antikörper
  • HAP2 Antikörper
  • hHLP1 Antikörper
  • HIP5 Antikörper
  • HLP Antikörper
  • Ref-1 Antikörper

Bezeichner auf Proteinebene für HAP1

AP endonuclease 1 , APEN , APEX nuclease , DNA-(apurinic or apyrimidinic site) lyase , apurinic-apyrimidinic endonuclease 1 , redox factor-1 , HAP-1 , huntingtin-associated protein 2 , neuroan 1 , huntingtin-associated protein 1 (neuroan 1)

GENE ID SPEZIES
11792 Mus musculus
9001 Homo sapiens
15114 Mus musculus
29430 Rattus norvegicus
607751 Canis lupus familiaris
618422 Bos taurus
Ausgewählte Anbieter für anti-HAP1 (HAP1) Antikörper
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