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Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Zusätzlich bieten wir Ihnen HtrA Serine Peptidase 3 Antikörper (28) und HtrA Serine Peptidase 3 Kits (16) und viele weitere Produktgruppen zu diesem Protein an.
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Human HTRA3 Protein expressed in Insect Cells - ABIN807971
Dynon, Heng, Puryer, Li, Walton, Endo, Nie: HtrA3 as an early marker for preeclampsia: specific monoclonal antibodies and sensitive high-throughput assays for serum screening. in PLoS ONE 2012
HTRA3 may be involved in folliculogenesis and luteinisation in the primate ovary. HTRA3 is possibly a factor involved in and potentially important for primate placentation.
Removal of the 6 additional LB loop residues caused a complete loss of the proper trimeric structure. Impairing their interactions with the PDZ domain decreased the amount of the trimers. The LB loop helps stabilize the DeltaN-HtrA3L oligomer structure suggesting involvement of the LB-PDZ interactions in the stabilization. A monomeric form of the DeltaN-HtrA3L is proteolytically inactive.
HtrA3 (zeige CAPN5 Proteine) expression in the peritumoral stroma of patients with stage II colorectal cancer is associated with high-grade tumor budding and may be a novel marker of poor outcome.
New insights into the structure and function of DeltaN-HtrA3 (zeige CAPN5 Proteine), which seems to have a unique combination of features among human HtrA (zeige HTRA1 Proteine) proteases.
HtrA3 (zeige CAPN5 Proteine) is likely to be associated with the acquisition of the invasive phenotype in oral squamous cell carcinoma cells and may be a potential prognostic marker for oral cance
HtrA1 (zeige HTRA1 Proteine) and HtrA3 (zeige CAPN5 Proteine) are crucial for trophoblast-decidual cell interaction in the control of trophoblast invasion.
Data indicate that the levels of high temperature requirement factor A3 (HtrA3)protein were lower in all subtypes of ovarian cancer and the lowest levels of HtrA3 (zeige CAPN5 Proteine) were in epithelial ovarian cancer.
Data indicate that in breast cancers with no lymphatic metastasis, the expression of HtrA3 (zeige CAPN5 Proteine) was lower in patients with estrogen receptor (ER (zeige ESR1 Proteine))- and progesterone receptor (PR (zeige PGR Proteine))-positive tumors.
HtrA3 (zeige CAPN5 Proteine) may have a role as an early marker for preeclampsia
results suggest that HtrA3 (zeige CAPN5 Proteine) variants may play different roles in cancer development, and that the increased HtrA3 (zeige CAPN5 Proteine)-L levels in thyroid tissue could be correlated with the development of malignant lesions
HTRA3 (zeige CAPN5 Proteine) is a target gene of the BACH1 (zeige BACH1 Proteine) transcription factor according to ChIP-seq analysis in HEK (zeige EPHA3 Proteine) 293 cells.
Both mRNA and protein of HtrA3 were localized specifically in the maternal decidua. Only the maternal decidual cells, but not blood vessels or uterine NK cells that are present in large numbers, were positive for HtrA3.
Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (By similarity).
Trypsin-like serine protease
, HtrA serine peptidase 3
, probable serine protease HTRA3-like
, high-temperature requirement factor A3
, pregnancy-related serine protease
, probable serine protease HTRA3
, serine protease HTRA3
, toll-associated serine protease