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HCFC1 is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. Zusätzlich bieten wir Ihnen HCFC1 Antikörper (41) und HCFC1 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Data show that Myc (zeige MYC Proteine) boxes (MbIV) is required for the association of MYC (zeige MYC Proteine) with the abundant transcriptional coregulator host cell factor-1 (HCF-1).
The M4 motif (ACTAYRNNNCCCR) is a functional regulatory bipartite cis (zeige CISH Proteine)-element, which engages a THAP11/HCF-1 complex via binding to the ACTAYR module, while the CCCRRNRNRC subsequence part constitutes a binding platform for Ikaros (zeige IKZF1 Proteine) and NFKB1 (zeige NFKB1 Proteine)
Beyond its well-known role in adding beta-O-GlcNAc (zeige OGT Proteine) to serine and threonine residues of nuclear and cytoplasmic proteins, OGT (zeige OGT Proteine) also acts as a protease in the maturation of the cell cycle regulator, HCF-1, and serves as an integral member of several protein complexes, many of them linked to gene expression. (Review)
findings show that cellular factors OCT2 and HCF1 bind OriP in association with Epstein-Barr virus nuclear antigen 1 to maintain elevated histone H3K4me3 and transcriptional enhancer function
O-GlcNAcylation of the transcription regulators Host Cell Factor-1 (HCF-1) and Ten-Eleven Translocation protein 2 (TET2) could be readily observed. Our study raises questions on the occurrence and abundance of O-GlcNAcylation as a histone modification
These results demonstrate that distinct OGT (zeige OGT Proteine)-binding sites in HCF-1 promote proteolysis, and provide novel insights into the mechanism of this unusual protease activity.
our work identifies plausible cellular consequences of missense HCFC1 variants and identifies likely and relevant disease mechanisms that converge on embryonic stages of brain development.
We report here two brothers with dysmorphic features and complex malformations resulting from an X-linked inherited cobalamin deficiency due to HCFC1 gene mutation.
THAP11, ZNF143 (zeige ZNF143 Proteine), and HCF-1 form a mutually dependent complex on chromatin, which is independent of E2F (zeige E2F1 Proteine) occupancy.
study reports the tetratricopeptide-repeat domain of O-GlcNAc (zeige OGT Proteine) transferase binds the carboxyl-terminal portion of an HCF-1 proteolytic repeat such that the cleavage region lies in the glycosyltransferase (zeige GTDC2 Proteine) active site above uridine diphosphate-GlcNAc; protein glycosylation and HCF-1 cleavage occur in the same active site
male epiblast-specific loss of Hcfc1 leads to a developmental arrest at E6.5 with a rapid progressive cell-cycle exit and an associated failure of anterior visceral endoderm migration and primitive streak formation.
Beyond its well-known role in adding beta-O-GlcNAc to serine and threonine residues of nuclear and cytoplasmic proteins, OGT (zeige OGT Proteine) also acts as a protease in the maturation of the cell cycle regulator, HCF-1, and serves as an integral member of several protein complexes, many of them linked to gene expression. (Review)
survival of the heterozygous Hcfc1(epiKO/+) female embryos llustrates the developmental plasticity of the post-implantation mouse embryo - in this instance, permitting survival of females heterozygous for an X-linked embryonic lethal allele
These results indicate that HCF-1 represents a novel transcriptional regulator required for maintaining pancreatic b-cell function.
Ronin/Hcf-1 controls a genetic program that contributes to the unimpeded growth of embryonic stem cells.
HCF-1 is an important component of the viral latency-reactivation cycle and it is regulated by association with a component that is distinct from the identified HCF-1 interaction factors
Bap1 (zeige BAP1 Proteine) helps to control cell proliferation by regulating HCF-1 protein levels and by associating with genes involved in the G(1)-S transition
HCFC1 plays a role in craniofacial development, which is in part mediated through the regulation of MMACHC (zeige MMACHC Proteine) expression
This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.
, VP16 accessory protein
, host cell factor 1
, VP16-accessory protein
, host cell factor C1