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HOXB1 belongs to the homeobox family of genes. Zusätzlich bieten wir Ihnen HOXB1 Proteine (13) und viele weitere Produktgruppen zu diesem Protein an.
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Data indicate that hox genes hoxb1a and hoxb1b have separate functions in hindbrain development.
Hoxb1b is likely to directly regulate ppp1r14al expression in rhombomere 4.
This is the first disease-associated HOXB1 mutation with a likely loss-of-function effect suggesting that all HOXB1 variants reported so far also have severe impact on activity of this transcriptional regulator
findings revealed a novel homozygous mutation p.Arg230Trp (c.688C>T) within the HOXB1 gene of three members of a Turkish family with hereditary congenital facial paresis (HCFP3)
HOXB1 functions as a tumor suppressor, regulated by miR (zeige MLXIP Antikörper)-3175 in glioma.
The resulting phenotype includes bilateral facial palsy, hearing loss, and strabismus (zeige VANGL2 Antikörper) and correlates extensively with the previously reported Hoxb1(-/-) mouse phenotype.
HOXA1 (zeige HOXA1 Antikörper) A218G and HOXB1 nINS/INS (zeige INS Antikörper) variants may not contribute significantly to autism spectrum disorders risk
Hoxb1 Expression Induces Cell Fate Changes in the Trunk Neural Tube.
analysis of a tethered-hopping model for protein-DNA binding and unbinding based on Sox2 (zeige SOX2 Antikörper)-Oct1 (zeige POU2F1 Antikörper)-Hoxb1 ternary complex simulations
Data show that inducible Hox (zeige MSH2 Antikörper) genes are selectively sensitive to the inhibition of actin polymerization and that actin polymerization is required for the assembly of a transcription complex on the regulatory region of the Hox (zeige MSH2 Antikörper) genes.
It is unlikely that HoxB1 plays a significant role in the genetic predisposition to autism.
UTX (zeige KDM6A Antikörper) directly binds to the HOXB1 locus and is required for its activation
Hoxa1 (zeige HOXA1 Antikörper) and Hoxb1 have diverged in function through either sub- or neo-functionalization and that the HoxA1 (zeige HOXA1 Antikörper) and HoxB1 proteins are not mutually interchangeable when expressed from the Hoxa1 (zeige HOXA1 Antikörper) locus
provide a comprehensive account of the developmental role of Hoxb1 in patterning the vestibular system and evidence for a remarkable developmental plasticity in the descending control of reflex limb movements
These data suggest that Hoxb1 and Hoxa1 (zeige HOXA1 Antikörper) are more phenotypically divergent than previously reported and support that sub- and/or neofunctionalization has occurred in these paralogous genes leading to a divergence of gene function and incomplete redundancy
Hoxb1 regulates proliferation and differentiation of second heart field progenitors in pharyngeal mesoderm and genetically interacts with Hoxa1 (zeige HOXA1 Antikörper) during cardiac outflow tract development.
Hoxb1 is required for the anterior-posterior identity of precursors that contribute to the lateral vestibular nucleus.
The results of this study show that ES neural differentiation and inducible Hox (zeige MSH2 Antikörper) gene expression can be used as a sensitive model system to systematically identify Hox (zeige MSH2 Antikörper) novel target genes.
identified a novel Hoxb3 (zeige HOXB3 Antikörper) binding site S3 on the Hoxb1 locus and confirmed protein binding to this site in hindbrain tissues from the Hoxb3 (zeige HOXB3 Antikörper)(Tg) mutant
Analysis of two distinct retinoic acid response elements in the homeobox (zeige PRRX1 Antikörper) gene Hoxb1 in transgenic mice
Hoxb1 has a role in neural crest development into glia of the peripheral nervous system
Results suggest that tissues are primed to express Hox (zeige MSH2 Antikörper) genes, such as Hoxb1, early in gastrulation, concomitant with primitive streak formation and extension, and that Hox (zeige MSH2 Antikörper) gene inducibility is transferred by cell to cell signalling.
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17.
, homeobox gene B-1
, homeobox protein Hox-B1a
, homeobox protein Hox-2I
, homeobox protein Hox-B1
, homeo box B1
, homeobox protein Hox-2.9
, homeobox-containing transcription factor Hoxb-1