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In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Zusätzlich bieten wir Ihnen HOXA5 Antikörper (118) und HOXA5 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.
loss of HOXA5 in mammary cells leads to loss of epithelial traits, an increase in stemness and cell plasticity, and the acquisition of more aggressive phenotypes.
ATRA may inhibit the proliferation of K562 cells and promote apoptosis by upregulating the HOXA5 mRNA and protein expression.
Knockdown of HOXA5 suppressed the proliferation and metastasis of esophageal squamous cell cancer cells.
high expression levels of HOXA5 mRNA and protein in children with ALL indicate that HOXA5 is closely associated with childhood ALL.
Downregulation of HOXA5 by shRNA may trigger apoptosis and overcome drug resistance in leukemia cells.
HOXA5-induced apoptosis was p53 (zeige TP53 ELISA Kits)-independent.
Among the mechanosensitive genes, the two transcription factors, HoxA5 and Klf3 (zeige KLF3 ELISA Kits), contain cAMP-response-elements methylation of which could serve as a mechanosensitive master switch in gene expression in atherosclerosis. (Review)
In colon cancer, HOXA5 is downregulated, and its re-expression induces loss of the cancer stem cell phenotype, preventing tumor progression and metastasis.
Ectopic expression of HOXA5 in highly invasive cancer cells suppressed cell migration, invasion, and filopodia formation in vitro and inhibited metastatic potential in vivo.
The NK AML (zeige RUNX1 ELISA Kits) patients with NPM1 (zeige NPM1 ELISA Kits) mutations exhibited elevated HOXA4 (zeige HOXA4 ELISA Kits) methylation and expression levels of HOXA5 and MEIS1 (zeige MEIS1 ELISA Kits) compared with the NPM1 (zeige NPM1 ELISA Kits) wildtype patients.
Hoxa5 possesses tissue-specific functions that differentially contribute to the morphogenesis of the respiratory tract.
mapping analysis allowed us to build hypotheses regarding HOXA5 functions in the nervous system after birth, such as a potential role in the establishment and refinement/plasticity of precerebellar circuits during postnatal and adult life
In presence of these inducing agents, lipid accumulation as well as expression of HoxA1 (zeige HOXA1 ELISA Kits), HoxA5, HoxC4 (zeige HOXC4 ELISA Kits) &HoxC8 (zeige HOXC8 ELISA Kits) markedly enhanced. Irrespective of presence or absence of T3, insulin (zeige INS ELISA Kits) down regulates HoxA10 (zeige HOXA10 ELISA Kits). T3 results in over expression of HoxA5, HoxC4 (zeige HOXC4 ELISA Kits) and HoxC8 (zeige HOXC8 ELISA Kits) genes, whereas insulin (zeige INS ELISA Kits) up regulates expression of only HoxC8 (zeige HOXC8 ELISA Kits)
Methylation profiling of HoxA5 gene promoter shows higher methylation in adult as compared to fetus in various somatic tissues of mouse being highest in adult spleen. However q-PCR results show higher expression during fetal stages being highest in fetal intestine followed by brain, liver and spleen. These results clearly indicate a strict correlation between DNA methylation (zeige HELLS ELISA Kits) and tissue-specific gene expression.
HoxA5 represents a novel molecule for restricting pathological and tumorigenic angiogenesis.
Enforced expression of Hoxa5 in haematopoietic stem cells leads to aberrant erythropoiesis in vivo.
YY1 (zeige YY1 ELISA Kits) acts as a transcriptional activator of Hoxa5 gene expression in mouse organogenesis.
Hoxa5 and Hoxb5 (zeige HOXB5 ELISA Kits) paralog genes share some functions during lung morphogenesis; Hoxa5 plays a predominant role.
Two Hox (zeige MSH2 ELISA Kits) genes, Hoxa5 and Hoxc5 (zeige HOXC5 ELISA Kits), control diverse aspects of phrenic motor column development.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis.
, homeo box A5
, similar to Homeobox protein Hox-A5 (Hox-1.3) (M2)
, hoxa5a protein
, homeobox protein Hox-1.3
, homeobox protein Hox-A5
, homeo box 1C
, homeobox protein HOXA5
, homeobox protein Hox-1C
, homeobox protein M2
, Homeobox protein Hox-A5