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In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Zusätzlich bieten wir Ihnen HOXA2 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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Cow (Bovine) Polyclonal HOXA2 Primary Antibody für WB - ABIN2780802
Alasti, Sadeghi, Sanati, Farhadi, Stollar, Somers, Van Camp: A mutation in HOXA2 is responsible for autosomal-recessive microtia in an Iranian family. in American journal of human genetics 2008
Show all 2 Pubmed References
Hoxa2 knockdown in Xenopus results in hyoid to mandibular homeosis.
The role of HOXA2 gene in dominant isolated microtia and the dysmorphogenetic effect of this gene on ear development
5 genomic variants in GSC (zeige GSC Antikörper), HOXA2 and PRKRA (zeige PRKRA Antikörper) were identified through mutational analysis in Chinese patients with microtia.
The Hoxa2-mediated decay of RCHY1 (zeige RCHY1 Antikörper) involves both the 19S and 20S proteasome (zeige PSMA5 Antikörper) complexes
HOXA2 acts as a suppressor or TBP (zeige TBP Antikörper)-antagonist to inhibit MMP-9 (zeige MMP9 Antikörper) expression; while methylation-mediated inactivation of HOXA2 in NPC (zeige NPC1 Antikörper) derepresses MMP-9 (zeige MMP9 Antikörper) production and increases invasion of NPC (zeige NPC1 Antikörper) cells.
we have identified a nonsense mutation (Q235*) in HOXA2 that segregates with bilateral nonsyndromic microtia and hearing loss through three generations of a family in an autosomal dominant pattern.
Lack of mutations in the coding region of HOXA2 among the sporadic microtia patients.
A missense mutation in the HOXA2 in a consanguineous iranian family with bilateral microtia was reported.
Hoxa2, Meis and Pbx proteins act cooperatively on the ECR, via a core 32 bp sequence, to regulate Hmx1 expression.
our data support that KPC2 regulates Hoxa2 by promoting its relocation to the cytoplasm.
Ectopic Hoxa2 expression results in the transformation of the proximal Meckel's cartilage and the malleus into a supernumerary styloid process (SP), a second pharyngeal arch-derived mammalian-specific skeletal structure.
Hoxa2 operates as a tissue-specific cofactor, enhancing Meis binding to specific sites that provide the second arch with its anatomical identity
The impairment of chondrogenic differentiation by Hoxa2 overexpression.
Data show that the transcription factor Hoxa2 binds to Pcp4 chromatin and regulates Pcp4 expression in the second arch.
Hoxa2 partly controls the morphogenesis of the pinna through the BMP signalling pathway and expression of Eya1 (zeige EYA1 Antikörper), which in humans is involved in branchio-oto (zeige PGAP1 Antikörper)-renal syndrome.
Hoxb2 (zeige HOXB2 Antikörper) antagonizes Hoxa2 during rostral hindbrain oligodendrogenesis.
the sustained expression of Hoxa2 in the chondrocyte lineage is characterized by a proportionate short stature resulting from skeletal growth defect.
The data reveals that Hoxa2 has large genome coverage and potentially regulates thousands of genes.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development.
, transcription factor Hoxa2b
, homeobox A1
, homeo box A1
, Homeobox protein Hox-A2
, Homeobox gene A11
, Homeobox gene A2
, homeobox protein Hox-1.11
, homeobox protein Hox-A2
, homeobox protein Hox-1K
, homeo box A2
, transcription factor Hoxa2
, homeobox protein Hox-A2-like