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HNRNPK belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). Zusätzlich bieten wir Ihnen Heterogeneous Nuclear Ribonucleoprotein K Antikörper (168) und Heterogeneous Nuclear Ribonucleoprotein K Proteine (15) und viele weitere Produktgruppen zu diesem Protein an.
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Human HNRNPK ELISA Kit für Sandwich ELISA - ABIN420739
Yang, Zeng, Xu, Chen, Xiang, Fu, Yin, Zhong, Zeng, Wang, You, Zeng: Heterogeneous nuclear ribonucleoprotein K is overexpressed and associated with poor prognosis in gastric cancer. in Oncology reports 2016
High HNRNPK expression is associated with pancreatic cancer.
Down-regulation of DAB2IP (zeige DAB2IP ELISA Kits) correlated negatively with hnRNPK and MMP2 (zeige MMP2 ELISA Kits) expressions in CRC (zeige CALR ELISA Kits) tissues. In conclusion, our study elucidates a novel mechanism of the DAB2IP (zeige DAB2IP ELISA Kits)/hnRNPK/MMP2 (zeige MMP2 ELISA Kits) axis in the regulation of CRC (zeige CALR ELISA Kits) invasion and metastasis, which may be a potential therapeutic target.
Tumor cells bearing a p53 (zeige TP53 ELISA Kits) mutation showed increased damage levels and delayed repair. Knockdown of hnRNPK applied simultaneously with irradiation reduced colony-forming ability and survival of tumor cells. Taken together, our data shows that hnRNPK is a relevant modifier of DNA damage repair and tumor cell survival. We therefore recommend further studies to evaluate the potential of hnRNPK as a drug target for improvement
Data suggest that hnRNPK plays role in heat shock response of cells by regulating HSF1; hnRNPK inhibits HSF1 activity, resulting in reduced expression of HSP27 and HSP70 mRNAs; hnRNPK also down-regulates binding of HSF1 to heat shock response element. (hnRNPK = heterogeneous-nuclear ribonucleoprotein K; HSF1 = heat shock transcription factor 1; HSP = heat-shock protein)
KRAS-mutant colorectal carcinoma shows intrinsic radioresistance along with rapid upregulation of hnRNP K in response to ionizing radiation that can effectively be targeted by MEK (zeige MAP2K1 ELISA Kits) inhibition.
Nujiangexathone A, a novel compound from Garcinia nujiangensis, down-regulates hnRNPK levels in cervical tumor cells, inducing cell cycle arrest.
Our study also suggests that loss of function variants in HNRNPK should be considered as a molecular basis for patients with Kabuki-like syndrome
these findings support a critical role for hnRNP K in the regulation of autophagy in drug-resistant leukemia cells, and this RNP (zeige RNPC3 ELISA Kits) is therefore a potential target of clinical drug-resistance treatment.
hnRNP K is a multifunctional protein that can regulate both oncogenic and tumor suppressive pathways through a plethora of chromatin-, DNA-, RNA-, and protein-mediated activates, suggesting its aberrant expression may have broad-reaching cellular impacts. (Review)
These results establish the role of hnRNP K and PCPB1 in the translational control of morphine-induced MOR expression in human neuroblastoma (NMB) cells as well as cells stably expressing MOR (NMB1).
A novel role for the nuclear localization signal in regulating hnRNP K protein stability in vivo has been described.
a previously unidentified function of phosphorylation at this phylogenetically conserved site and implicates hnRNPK as an intracellular molecular target of ERK (zeige MAPK1 ELISA Kits)-mediated signaling in axon outgrowth.
hnRNP K is essential for successful optic axon regeneration via a novel post-transcriptional regulatory pathway.
A crucial role is reported for hnrpk in axon development in Xenoops laevis.
hnRNPK recruits PCGF3 (zeige PCGF3 ELISA Kits)/5-PRC1 (zeige PRC1 ELISA Kits) to the Xist RNA B-repeat to establish polycomb (zeige CBX2 ELISA Kits)-mediated chromosomal silencing.
the beneficial actions of insulin (zeige INS ELISA Kits) in diabetic nephropathy appear to be mediated, in part, by suppressing renal Nrf2 (zeige NFE2L2 ELISA Kits) and Agt (zeige AGXT ELISA Kits) gene transcription and preventing Nrf2 (zeige NFE2L2 ELISA Kits) stimulation of Agt (zeige AGXT ELISA Kits) expression via hnRNP F (zeige HNRNPF ELISA Kits)/K.
the cytoplasmic hnRNPK interacts with GSK3beta (zeige GSK3b ELISA Kits) and regulates its function.
Data implicate hnRNPK in the development of hematological disorders and suggest hnRNPK acts as a tumor suppressor.
These findings functionally integrate K17 (zeige KRT17 ELISA Kits), hnRNP K, and gene expression along with RSK (zeige RPS6KA1 ELISA Kits) and CXCR3 (zeige CXCR3 ELISA Kits) signaling in a keratinocyte-autonomous axis and provide a potential basis for their implication in tumorigenesis
Nova haploinsufficient mice had spontaneous epilepsy
HnRNP K-3' UTR (zeige UTS2R ELISA Kits) complex inhibits TAK1 (zeige NR2C2 ELISA Kits) mRNA translation.
hnRNP-K regulates extracellular matrix, cell motility, and angiogenesis pathways. Involvement of the selected genes (Cck (zeige CCK ELISA Kits), Mmp-3 (zeige MMP3 ELISA Kits), Ptgs2 (zeige PTGS2 ELISA Kits), and Ctgf (zeige CTGF ELISA Kits)) and pathways was validated by gene-specific expression analysis
HNRNPK affects production of the essential NEAT1_2 isoform by negatively regulating its 3'-end polyadenylation by arresting CFIm (zeige CPSF6 ELISA Kits) complex binding near NEAT1_1's alternative polyadenylation site.
Mitochondrial superoxide production stimulated by adiponectin serves as a trigger to initiate the translocation of hnRNP K, which in turn promotes UCP2 (zeige UCP2 ELISA Kits) expressions in liver.
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference\; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized.
dC-stretch binding protein
, transformation upregulated nuclear protein
, dC stretch-binding protein
, hnRNP K
, heterogeneous nuclear ribonucleoprotein K
, heterogeneous nuclear ribonucleoprotein k
, hnRNP-K protein
, heterogenous nuclear ribonucleoprotein K
, heterogeneous nuclear ribonucleoprotein K-like