anti-Hepatic and Glial Cell Adhesion Molecule (HEPACAM) Antikörper

The protein encoded by HEPACAM is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. Zusätzlich bieten wir Ihnen Hepatic and Glial Cell Adhesion Molecule Proteine (11) und Hepatic and Glial Cell Adhesion Molecule Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
HEPACAM 220296 Q14CZ8
HEPACAM 72927 Q640R3
HEPACAM    
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Top anti-Hepatic and Glial Cell Adhesion Molecule Antikörper auf antikoerper-online.de

Showing 10 out of 50 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-HEPACAM Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>HT1080 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert WB HEPACAM Antibody (C-term) (ABIN656770) western blot analysis in HepG2 cell line lysates (35 µg/lane). This demonstrates the HEPACAM antibody detected the HEPACAM protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of hepaCAM Antibody (C-term) in HepG2 cell line lysates (35ug/lane). This demonstrates the HEPACAM antibody detected the HEPACAM protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Antigen: 0.2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Goat-Anti-Rabbit IgG at 1: 5000;  TMB staining;  Read the data in MicroplateReader by 450 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$295.90
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert WB   100 μL Anmelden zum Anzeigen 16 Days
$323.13
Details
Human Kaninchen Unkonjugiert WB   100 μL Anmelden zum Anzeigen 16 Days
$323.13
Details
Human Kaninchen Unkonjugiert WB Western Blot: HEPACAM Antibody [NBP1-60020] - HT1080 cell lysate, concentration 0.2-1 ug/ml. 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$447.56
Details
Human Kaninchen Alexa Fluor 594 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
Details
Human Kaninchen HRP IHC (p), WB   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
Details

HEPACAM Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-Hepatic and Glial Cell Adhesion Molecule Antikörper

  1. Human Polyclonal HEPACAM Primary Antibody für IF (p), IHC (p) - ABIN758651 : Maes, McGill, da Silva, Abels, Lebofsky, Maria Monteiro de Araújo, Tiburcio, Veloso Alves Pereira, Willebrords, Crespo Yanguas, Farhood, Beschin, Van Ginderachter, Zaidan Dagli, Jaeschke, Cogliati et al.: Involvement of connexin43 in acetaminophen-induced liver injury. ... in Biochimica et biophysica acta 2016 (PubMed)

Weitere Antikörper gegen Hepatic and Glial Cell Adhesion Molecule Interaktionspartner

Human Hepatic and Glial Cell Adhesion Molecule (HEPACAM) Interaktionspartner

  1. DNMT1 (zeige DNMT1 Antikörper) up-regulation induced by IL-6 (zeige IL6 Antikörper)/STAT3 (zeige STAT3 Antikörper) signaling was indispensable for IL-6 (zeige IL6 Antikörper)-mediated hepaCAM loss in renal cell carcinoma (zeige MOK Antikörper) (RCC (zeige XRCC1 Antikörper)) cell lines ACHN (zeige LARP6 Antikörper) and 769-P, while DNMT3b (zeige DNMT3B Antikörper) up-regulation was crucial for hepaCAM loss in A498.

  2. Out of 20 patients, macrocephaly, classic MRI (zeige C7ORF49 Antikörper) features, motor development delay and cognitive impairment were detected in 20(100%), 20(100%), 17(85%) and 4(20%) patients, respectively. 20(100%) were clinically diagnosed with MLC. 19(95%) were genetically diagnosed with 10 novel mutations in MLC1, MLC1 and GlialCAM mutations were identified in 15 and 4 patients, respectively

  3. HepaCAM depletion was discovered in bladder cancer tissues compared with adjacent normal tissues, and the decreased level was associated with the degradation of FoxO3 (zeige FOXO3 Antikörper).

  4. HepaCAM proteins were significantly decreased in bladder carcinoma. Low hepaCAM was not statistically associated with clinicopathological characteristics of the patients. HepaCAM overexpression activated caspase 3 (zeige CASP3 Antikörper)/8/9, downregulated poly-ADP ribose polymerase (zeige PARP1 Antikörper) and p-SMAD2 (zeige SMAD2 Antikörper)/3, and decreased apoptosis.

  5. The suppressive roles of HEPACAM in NSCLC.

  6. Due to the ability to reactivate expression of hepaCAM and inhibit growth of bladder cancer cells, AZAC may represent an effective treatment for bladder cancer.

  7. The extracellular domain of GlialCAM is necessary for cell junction targeting and for mediating interactions with itself or with MLC1 and ClC-2 (zeige CLCN2 Antikörper).

  8. HepaCAM may prevent the translocation of PKCepsilon (zeige PRKCE Antikörper) from cytosolic to particulate fractions, resulting in the inhibition of 786-0 cell proliferation.

  9. GlialCAM is able to interact with all CLC (zeige CLC Antikörper) channels tested in this study, targeting them to cell junctions and activating them by stabilizing the open configuration of the common gate

  10. Results allow classifying the effect of HEPACAM gene mutations in different subtypes and authors indicate different cellular mechanisms that lead to megalencephalic leukoencephalopathy pathogenesis.

Mouse (Murine) Hepatic and Glial Cell Adhesion Molecule (HEPACAM) Interaktionspartner

  1. we demonstrate an evolutionary conserved role for MLC1 in regulating glial surface levels of GLIALCAM, and this interrelationship explains why patients with mutations in either gene (MLC1 or GLIALCAM) share the same clinical phenotype.

  2. Data indicate that membrane protein MLC1 is crucial for proper localization of adhesion molecule (zeige NCAM1 Antikörper) GlialCAM and chloride channel (zeige CLCA1 Antikörper) ClC-2 (zeige CLCN2 Antikörper), and for changing ClC-2 (zeige CLCN2 Antikörper) currents.

  3. GlialCAM, an immunoglobulin-like cell adhesion molecule (zeige MCAM Antikörper) is expressed in glial cells of the central nervous system.

Hepatic and Glial Cell Adhesion Molecule (HEPACAM) Antigen-Profil

Protein Überblick

The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene.

Genbezeichner und Symbole assoziert mit HEPACAM

  • hepatic and glial cell adhesion molecule (HEPACAM) Antikörper
  • hepatocyte cell adhesion molecule (Hepacam) Antikörper
  • 2900042E01Rik Antikörper
  • GlialCAM Antikörper
  • Hepn1 Antikörper
  • MLC2A Antikörper
  • MLC2B Antikörper

Bezeichner auf Proteinebene für HEPACAM

hepatocyte cell adhesion molecule , protein hepaCAM

GENE ID SPEZIES
100064233 Equus caballus
220296 Homo sapiens
489305 Canis lupus familiaris
521015 Bos taurus
72927 Mus musculus
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