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The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. Zusätzlich bieten wir Ihnen Hemoglobin Alpha, Adult Chain 1 Antikörper (39) und Hemoglobin Alpha, Adult Chain 1 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
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identify a novel sequence on Hb alpha that is important for Hb alpha/eNOS (zeige NOS3 Proteine) complex formation and is critical for nitric oxide signaling at myoendothelial junctions
The human locus establishes prominent sites of Polycomb (zeige CBX2 Proteine) complex recruitment in pluripotent stem cells, whereas the corresponding mouse locus does not.
The objective of this study was to test whether amino acid differences among triplicated alpha-globin paralogs are attributable to a relaxation of purifying selection or to a history of positive selection.
It is suggested that the higher expression of hemoglobin (zeige HBB Proteine) alpha1 in the brain may be associated with ECM (zeige MMRN1 Proteine) and could be a source of excess heme, a molecule that is considered to trigger the pathogenesis of cerebral malaria.
These data suggest that CP2b (zeige CYP27B1 Proteine) potentiate erythroid cell-specific alpha-globin expression by recruiting CP2c into the nucleus.
Carriers of Hb Nanning are asymptomatic and could be missed by screening based on MCV and MCH (zeige PMCH Proteine) cutoffs of <80.0 fL and <27.0 pg, respectively. Both carriers of the mutation in the study have MCV and MCH (zeige PMCH Proteine) values that are 2 standard deviations (SDs (zeige SDS Proteine)) below normal, as would be predicted for an alpha+-thal.
Data indicate that binding of hemoblobin (Hb) to glycoprotein1balpha (GP1balpha) induced platelet activation plays a crucial role in thrombus formation on immobilized von Willebrand factor (VWF (zeige VWF Proteine)) or type I collagen under shear stresses.
Hb Adana mutation was preferentially present in the alpha2-globin genes in Malays compared to the other ethnicities in Malaysia.
Seven novel nondeletional alpha-thalassemia mutations localized on the alpha2-globin gene in the heterozygous state were identified
Gene frequency for HBA2 (zeige HBa2 Proteine):c.301-24delGinsCTCGGCCC carriers among the Chinese population in Guangxi.
Hemoglobin Constant Spring mutation in Southeast Asians with thalassemia.
We report herein for the first time the description of HbA2 (zeige HBa2 Proteine)' in the Tunisian population.
In maturing RBC (zeige CACNA1C Proteine) progenitors AHSP (zeige aHSP Proteine) bind to free alpha-globin (zeige HBA1 Proteine) chains to increase the HbA (zeige SCN2A Proteine) production. (Review)
Two mutations detected the -a(3,7) single gene deletion found in 75% of cases and the nongene deletion a2 IVS1 [-5nt (zeige ACPP Proteine)] in the remaining samples
Copy number variations in alpha-globin (zeige HBA1 Proteine) 2 gene is associated with increased levels of HbF with beta thalassemia.
Data indicate that on incubating hemoglobin with glyoxal for 0-20 days, advanced glycation end products (AGEs) were detected on day 20.
Residues 33-61a of hemoglobin alpha-chain from cattle tick gut (zeige GUSB Proteine) exhibit nonconventional conformation for an antimicrobial peptide (zeige cAMP Proteine), bound to sodium dodecyl sulfate micelles. The peptide is able to disrupt the bacterial membrane of Micrococcus luteus A270.
The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin\; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1\; some nondeletion alpha thalassemias have also been reported.
alpha 1 globin
, alpha globin 1
, haemaglobin alpha 1
, hemoglobin alpha chain
, hemoglobin subunit alpha
, Hemoglobin alpha chain
, globin, alpha 1
, alpha globin
, alpha-2 globin