anti-Hematopoietic Cell Signal Transducer (HCST) Antikörper

HCST encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. Zusätzlich bieten wir Ihnen HCST Kits (5) und HCST Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
HCST 10870 Q9UBK5
HCST 23900 Q9QUJ0
HCST 474146 Q6X9T8
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Top anti-HCST Antikörper auf antikoerper-online.de

Showing 10 out of 31 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Ziege Unkonjugiert ELISA, WB ABIN334384 (0.2µg/ml) staining of human spleen lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$326.89
Details
Human Ziege Unkonjugiert ELISA, WB ABIN188679 (0.2?g/ml) staining of Human Spleen lysate (35?g protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Western Blot: HCST Antibody [ABIN1886793] - (0.2ug/ml) staining of human spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$408.19
Details
Human Ziege Unkonjugiert EIA, WB   0.1 mg Anmelden zum Anzeigen 12 bis 15 Tage
$375.38
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Paraformaldehyde-fixed, paraffin embedded rat spleen tissue, Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes, Blocking buffer (normal goat serum) at 37°C for 30min, Antibody incubation with HCST Polyclonal Antibody, Unconjugated  at 1:400 overnight at 4°C, followed by a conjugated secondary for 20 minutes and DAB staining. 100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$295.90
Details
Human Ziege Unkonjugiert ELISA 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$610.50
Details
Human Ziege Unkonjugiert ELISA, WB 0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$481.25
Details
Human Kaninchen Alexa Fluor 488 IF (p)   100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$405.90
Details
Human Kaninchen Alexa Fluor 350 IF (p)   100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$405.90
Details
Human Kaninchen Alexa Fluor 555 IF (p)   100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$405.90
Details
Human Kaninchen Alexa Fluor 647 IF (p)   100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$405.90
Details

HCST Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Human , ,
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Mouse (Murine)


Rat (Rattus)


Am meisten referenzierte anti-HCST Antikörper

  1. Human Polyclonal HCST Primary Antibody für ELISA, WB - ABIN188679 : Upshaw, Arneson, Schoon, Dick, Billadeau, Leibson: NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells. in Nature immunology 2006 (PubMed)

Weitere Antikörper gegen HCST Interaktionspartner

Zebrafish Hematopoietic Cell Signal Transducer (HCST) Interaktionspartner

  1. The structure of the adaptor protein dap10 has been identified in the zebrafish genome.

Human Hematopoietic Cell Signal Transducer (HCST) Interaktionspartner

  1. These results suggest that NKG2D (zeige KLRK1 Antikörper)-DAP10 endocytosis represents a means to decrease cell surface receptor abundance, as well as to control signaling outcome in cytotoxic lymphocytes.

  2. findings indicate that the functional interaction between RAGE (zeige AGER Antikörper) and DAP10 coordinately regulates S100A8 (zeige S100A8 Antikörper)/A9-mediated survival and/or apoptotic response of keratinocytes

  3. TGF-beta1 (zeige TGFB1 Antikörper) may reduce the expression of NKG2D (zeige KLRK1 Antikörper)/DAP10 and 2B4 (zeige CD244 Antikörper)/SAPin patients with hepatitis B.

  4. HMBOX1 (zeige HMBOX1 Antikörper) negatively regulates the expression of NKG2D (zeige KLRK1 Antikörper) and the activation of the NKG2D (zeige KLRK1 Antikörper)/DAP10 signaling pathway in NK cells.

  5. Other gamma(c) cytokines act similarly to IL-2 (zeige IL2 Antikörper) in up-regulating DAP10 expression and NKG2D (zeige KLRK1 Antikörper)-DAP10 surface expression.

  6. TGF-BETA1 (zeige TGFB1 Antikörper) down-modulates surface NKG2D (zeige KLRK1 Antikörper) expression by controlling the transcriptional and translational levels of DAP10.

  7. A transgenic mouse model demonstrates that induction of tolerance in Ly49H (zeige KLRA8 Antikörper)-positive natural killer (NK) cells by chronic exposure to virus-encoded ligand m157 requires signaling through the Ly49H (zeige KLRA8 Antikörper) adaptor protein DAP12 (zeige TYROBP Antikörper), not the DAP10 adaptor protein.

  8. NKG2D (zeige KLRK1 Antikörper)-DAP10 triggers human NK cell-mediated killing via a Syk (zeige SYK Antikörper)-independent regulatory pathway.

  9. both activated and expanded CD8 (zeige CD8A Antikörper)+ T cells and NK cells use DAP10 for cytolysis

  10. Downstream targets of DAP10 and DAP12 (zeige TYROBP Antikörper) are constitutively activated in large granular lymphocyte leukemia cells, and expression of dominant-negative DAP10 and DAP12 (zeige TYROBP Antikörper) dramatically reduces their lytic capacity.

Mouse (Murine) Hematopoietic Cell Signal Transducer (HCST) Interaktionspartner

  1. Adoptive transfer of murine T cells expressing a chimeric-PD1 (zeige PDCD1 Antikörper)-Dap10 receptor may induce a preferential cytokine profile and T-cell differentiation phenotype for anti-lymphoma therapies.

  2. Rat and mouse CD94 (zeige KLRD1 Antikörper)/NKG2C (zeige KLRC2 Antikörper) heterodimers bind efficiently to both DAP12 (zeige TYROBP Antikörper) and DAP10; this binding is critically dependent on the transmembrane lysine residue of CD94 (zeige KLRD1 Antikörper).

  3. contributes to CD8 (zeige CD8A Antikörper)(+) T cell-mediated cytotoxic effector mechanisms during Mycobacterium tuberculosis infection

  4. demonstrate a previously uncharacterized interaction of SHIP1 (zeige INPP5D Antikörper) with DAP12 (zeige TYROBP Antikörper) that limits TREM2 (zeige TREM2 Antikörper)- and DAP12 (zeige TYROBP Antikörper)-dependent signaling and identify a mechanism through which SHIP1 (zeige INPP5D Antikörper) regulates key ITAM-containing receptors by blocking the binding and activation of PI3K

  5. selective associations with DAP10 determine stimulatory versus costimulatory activity of NKG2D (zeige KLRK1 Antikörper)

  6. Differential requirements for Vav (zeige VAV1 Antikörper) proteins in DAP10- and ITAM-mediated NK cell cytotoxicity.

  7. The importance of Fcgr3 (zeige CD16 Antikörper)/Cd3z (zeige CD247 Antikörper), Hcst, and Tyrobp (zeige TYROBP Antikörper) in the activation of NK cells in the uterus of pregnant mice is reported.

  8. Review of immune reactions against syngeneic tumors reveals an important physiological role of DAP10 adapter protein (zeige GRB10 Antikörper) signaling in maintaining tolerance to self, by controlling the development and activation threshold of autoreactive T cells.

  9. DAP10 signaling is involved in adjusting the activation threshold and generation of natural killer T cells and regulatory T cells to avoid autoreactivity, but it also modulates antitumor mechanisms.

  10. improved rejection of B16 melanomas in DAP10-deficient mice

Cow (Bovine) Hematopoietic Cell Signal Transducer (HCST) Interaktionspartner

HCST Antigen-Profil

Protein Überblick

This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.

Genbezeichner und Symbole assoziert mit HCST

  • hematopoietic cell signal transducer (HCST) Antikörper
  • hematopoietic cell signal transducer (hcst) Antikörper
  • hematopoietic cell signal transducer (Hcst) Antikörper
  • Dap10 Antikörper
  • HCST Antikörper
  • KAP10 Antikörper
  • PIK3AP Antikörper

Bezeichner auf Proteinebene für HCST

hematopoietic cell signal transducer , dap10 , DNAX-activation protein 10 , kinase assoc pro of ~10kDa , kinase assoc protein , membrane protein DAP10 , phosphoinositide-3-kinase adaptor protein , transmembrane adapter protein KAP10 , putative membrane adaptor molecule , immunoreceptor DAP10

GENE ID SPEZIES
612627 Canis lupus familiaris
748082 Pan troglodytes
100101460 Danio rerio
10870 Homo sapiens
23900 Mus musculus
474146 Rattus norvegicus
767892 Bos taurus
397267 Sus scrofa
574152 Macaca mulatta
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