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HERC2 belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. Zusätzlich bieten wir Ihnen HERC2 Antikörper (19) und viele weitere Produktgruppen zu diesem Protein an.
identified HERC2, a HECT domain-containing E3 ligase, as being responsible for polyubiquitination of USP33 (zeige USP33 ELISA Kits).
HERC2 acts as a regulator of E6AP (zeige ube3a ELISA Kits).
Evaluated the association of seven OCA2-HERC2 SNPs and haplotypes with pigmentation characteristics (eye, skin, hair and freckles) in the highly admixed and phenotypically heterogeneous Brazilian population. Such SNPs and haplotypes could be deemed as good predictors for the presence of freckles and for skin, eye and hair pigmentation in the Brazilian population.
We showed that loss of HERC2 function leads to the accumulation of XPA and BRCA1 in the patient's fibroblasts and generates decreased sensitivity to apoptosis and increased level of DNA repair
SNP rs12913832 in HERC2 was found to be strongly associated with blue eye colour. SNP associations with hair and skin colour were weaker and genotypes less predictive.
Ubiquitin-dependent NCOA4 turnover is promoted by excess iron and involves an iron-dependent interaction between NCOA4 and the HERC2 ubiquitin ligase.
Data show that histone H2A deubiquitinase USP16 interacts with E3 ubiquitin-protein ligase HERC2, negatively regulates DNA damage-induced ubiquitin foci formation, and is required for termination of the ubiquitin signal.
Results identify HERC2 as a regulator of p53 (zeige TP53 ELISA Kits) signaling.
results thus suggest that HERC2 regulates the basal turnover of FBXL5, and that this ubiquitin-dependent degradation pathway contributes to the control of mammalian iron metabolism
ATR (zeige ANTXR1 ELISA Kits)-mediated phosphorylation induces XPA (zeige XPA ELISA Kits) stabilization by antagonizing HERC2-catalyzed XPA (zeige XPA ELISA Kits) ubiquitination.
given a particular HERC2/OCA2 genotype, males are more prone to have lighter eye colors than predicted by their genotypes, while females tend to have darker eye colors than predicted
This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16.
, E3 ubiquitin-protein ligase HERC2
, HECT domain and RCC1-like domain-containing protein 2
, probable E3 ubiquitin-protein ligase HERC2
, hect domain and RCC1-like domain-containing protein 2
, hect domain and RLD 2