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HSP encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. Zusätzlich bieten wir Ihnen Heat Shock Protein Antikörper (27) und Heat Shock Protein Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
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These results hereby imply SelK may regulate the release of Ca(2+) by CHERP and play an important role in the proliferation and differentiation of T cell by TCR stimulation.
SELK has the dynamic structural features to be defined as a HUB protein able to interact with multiple members.
overexpression of SelK can inhibit human cancer cell Matrigel adhesion and migration
IP3R palmitoylation is a critical regulator of Ca(2+) flux in immune cells and define a previously unidentified DHHC/Selk complex responsible for this process.
SelK reduces hydrophobic substrates, such as phospholipid hydroperoxides, which are known to damage cell membranes.
Polymorphisms in thioredoxin reductase (zeige PRDX5 Proteine) and selenoprotein K genes and selenium status modulate risk of prostate cancer
Data suggest that SelK is involved in the Derlin-dependent ERAD of glycosylated misfolded proteins and that the function defined by the prototypic SelK is the widespread function of selenium in eukaryotes.
Human lymphocyte SelK colocalizes with endoplasmic reticulum (zeige CCR1 Proteine) biomarker KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum receptor.
SelK is a novel antioxidant in cardiomyocytes and is related to the regulation of cellular redox balance.
interaction between SelK and p97(VCP (zeige vcp Proteine)) is SelS (zeige SELS Proteine)-dependent, and the resulting ERAD complex (SelS (zeige SELS Proteine)-p97(VCP (zeige vcp Proteine))-SelK) plays an important role in ERAD and ER stress
Selk deficiency through genetic deletion or low selenium in culture media leads to low expression of the IP3R due to a defect in IP3R palmitoylation. DHHC6/Selk interactions in the ER membrane depend on SH3/SH3 binding domain interactions.
Selk is important for stable, localized expression of CD36 (zeige CD36 Proteine) in macrophages during inflammation, thereby contributing to foam cell formation and atherogenesis.
Selenoprotein K is a novel target of m-calpain (zeige CAPN2 Proteine), and cleavage is regulated by Toll (zeige TLR4 Proteine)-like receptor 2,3,4 and 9-induced calpastatin (zeige CAST Proteine) in macrophages
Sel K-deficient T cells exhibit decreased chemokine receptor (zeige CCR1 Proteine)-mediated calcium flux.
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant.
Heat Shock Protein family member (hsp-25)
, heat shock protein
, heat shock protein, 30 kDa