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HES6 encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Zusätzlich bieten wir Ihnen Hairy and Enhancer of Split 6 (Drosophila) Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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the PT enhancer with the 3'UTR (zeige UTS2R Antikörper) of hes6 responded to the inhibition of retinoic acid synthesis and fibroblast growth factor signaling in a manner similar to endogenous hes6.
hes6, the clock gene that does not oscillate, responds to negative feedback
Data define a network of Her/Hes (zeige ATCAY Antikörper) dimers underlying transcriptional negative feedback within the zebrafish segmentation clock, where Her7 acts directly within the delayed negative feedback as a DNA-binding heterodimer with Hes6.
Forms specific heterodimers with her1 (zeige EGFR Antikörper), which may directly be required for regulating further target genes.
Hes6 is involved in the regulation of neuroblast differentiation during adult neurogenesis, but does not influence integration into mature neurons.
Hes6 physically and functionally interacts with RelA (zeige NFkBP65 Antikörper)-containing NF-kappaB (zeige NFKB1 Antikörper) complexes in cortical progenitor cells to control cortical neurogenesis.
Hes6 regulates myogenic differentiation.
Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity.
Hes6 is a regulator of the neurogenic phase of cortical development by promoting neuronal fate while suppressing astrocyte differentiation.
ATOH1 (zeige ATOH1 Antikörper) activates HES6 transcription through binding to three clustered E boxes of its promoter
Data reveal a role for Ascl1 (zeige ASCL1 Antikörper) in the regulation of Hes6, a proneurogenic factor that inhibits Notch (zeige NOTCH1 Antikörper) signaling to promote neural rather than glial differentiation
prostate cancer-specific up-regulation of NOTCH3 (zeige NOTCH3 Antikörper) and HES6, is reported.
HES6 mutations are associated with castration resistant and androgen independent tumors in prostate cancer.
HES6 is up-regulated in aggressive human prostate cancer and drives tumour growth by enhancing the transcriptional activity of the AR, which is preferentially directed to a regulatory network enriched for transcription factors such as E2F1 (zeige E2F1 Antikörper).
HES6 contributes to the pathogenesis of alveolar rhabdomyosarcoma by enhancing both proliferation and cell motility.
HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation.
Data suggest that Hes-6 is a potential oncogene (zeige RAB1A Antikörper) overexpressed in breast cancer, with a tumor-promoting and proliferative function. Hes-6 is a novel estrogen-regulated gene in breast cancer cells.
Here, we show that WRPW motif deletion mutant Hes6 protein is substantially stabilized in comparison to the full length protein and that the enhanced stability is due to its resistance to proteasomal degradation.
Hes6 overexpression using a retroviral vector led to a decrease in Hes1 levels, an increase in beta-cell transcription factors and partial restoration of insulin (zeige INS Antikörper) expression
Increased expression of Notch3 (zeige NOTCH3 Antikörper), Jagged1 (zeige JAG1 Antikörper), Hes1, and Hes6 gene transcripts were observed during differentiation of cultured human skeletal muscle cells.
This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.
hairy and enhancer of split 6
, transcription cofactor HES-6
, class B basic helix-loop-helix protein 41