Hairless (HR) ELISA Kits

May act as a transcription factor that could act on to regulate one of the phases of hair growth.. Zusätzlich bieten wir Ihnen Hairless Antikörper (30) und Hairless Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Human HR HR 55806 O43593
Anti-Ratte HR HR 60563 P97609
Anti-Maus HR HR 15460 Q61645
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Weitere ELISA Kits für Hairless Interaktionspartner

Human Hairless (HR) Interaktionspartner

  1. mammalian Hr is a phosphoprotein which can exert cross-talk with the p53 (zeige TP53 ELISA Kits) pathway with important implications for the regulation of cell proliferation and differentiation in tissues such as skin and brain where Hr is highly expressed.

  2. We have identified two recurrent missense mutations in U2HR c.1A>T (p. Met1?) and c.104A>G (p.*35Wext1263*) in two Chinese Han families with Marie Unna Hereditary Hypotrichosis.

  3. study reports two cases of Marie Unna hereditary hypotrichosis; a novel nonsense mutation of U2HR was identified in the second case, but no causative mutation in U2HR or EPS8L3 (zeige EPS8L3 ELISA Kits) was found in the first case

  4. we have identified a mutation, c.74C>T, in a Chinese family with MUHH, which has been previously described in a family from Hungary. Our findings therefore indicate the prevalence of this mutation in diverse populations.

  5. Findings indicate that hairless (HR) is a H3K9 demethylase (zeige MBD2 ELISA Kits) that regulates epidermal homeostasis via direct control of its target genes.

  6. Unliganded VDR (zeige CYP27B1 ELISA Kits) upregulates the expression of hairless, the gene product of which acts as a downstream comodulator to feedback-repress DKKL1 (zeige DKKL1 ELISA Kits) and SOSTDC1 (zeige SOSTDC1 ELISA Kits).

  7. deletion mutants of hairless indicate that the JmjC domain contributes to the co-repressor activity

  8. Mutations in the gene HR coding for the hairless protein are associated with an autosomal recessive form of alopecia universalis

  9. Marie Unna hereditary hypotrichosis is caused by a novel mutation (U2HR) in the human hairless transcript.

  10. study reports a family with Marie Unna hereditary hypotrichosis (MUHH) from Turkey; identified the mutation c.2T > C (M1T) in all affected family members; concluded that there may be considerable clinical variations in MUHH

Mouse (Murine) Hairless (HR) Interaktionspartner

  1. This study examinedthe uncommon phenotype and using microarray analyses and functional studies, we found that beta-catenin was mediated by Hr. Progenitor keratinocytes from the bulge region differentiate into both epidermis and sebaceous glands, and fail to adopt the hair keratinocytes fate in the mutant scalp, due to the decreased Wnt/beta-catenin signaling in the absence of the hairless protein.

  2. HR regulates expression of genes in the MSX2 regulatory pathway, which explains abnormal hair follicle formation in Hr(Hp)/Hr(Hp) skin.

  3. Hairless is required for adipocyte differentiation.

  4. Hr loss results in a state of uncontrolled epidermal proliferation that promotes tumor development, and Hr mutant mice should no longer be considered merely hairless 'wild-type' mice

  5. regulation of Dlx3 (zeige DLX3 ELISA Kits) by HR affects the IRS (zeige IARS ELISA Kits) keratin expression, thus modulating the formation of IRS (zeige IARS ELISA Kits) of hair follicle.

  6. Foxe1 (zeige FOXE1 ELISA Kits) mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes.

  7. Hr evokes an anti-apoptotic response by disrupting a p53 (zeige TP53 ELISA Kits) dependent pathway involving Bcl2 (zeige BCL2 ELISA Kits) family members.

  8. hairless phenotype in CR rats is not allelic with mouse hairless

  9. This thyroid hormone (zeige PTH ELISA Kits)-regulated corepressor associates with histone deacetylases in neonatal rat brain.

  10. HR regulates the precise timing of Wnt (zeige WNT2 ELISA Kits) signaling required for hair follicle regeneration.

Hairless (HR) Antigen-Profil

Beschreibung des Gens

This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by multiple regulatory ORFs that exist upstream of the primary ORF. Mutations in one of these upstream ORFs, U2HR, cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit Hairless (HR) ELISA Kits

  • HR, lysine demethylase and nuclear receptor corepressor (HR) Antikörper
  • HR, lysine demethylase and nuclear receptor corepressor (Hr) Antikörper
  • hairless (Hr) Antikörper
  • ALUNC Antikörper
  • AU Antikörper
  • ba Antikörper
  • bldy Antikörper
  • hr Antikörper
  • HSA277165 Antikörper
  • MUHH Antikörper
  • MUHH1 Antikörper
  • N Antikörper
  • rh Antikörper
  • rh-bmh Antikörper
  • rhino Antikörper

Bezeichner auf Proteinebene für Hairless (HR) ELISA Kits

hairless homolog , protein hairless , hairless homolog (mouse) , hairless protein , protein hairless-like

55806 Homo sapiens
100053727 Equus caballus
486130 Canis lupus familiaris
785815 Bos taurus
464040 Pan troglodytes
60563 Rattus norvegicus
397617 Sus scrofa
443241 Ovis aries
574164 Macaca mulatta
100033094 Monodelphis domestica
100357019 Oryctolagus cuniculus
100451474 Pongo abelii
100478044 Ailuropoda melanoleuca
15460 Mus musculus
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