HUS1 Checkpoint Homolog (S. Pombe) Proteine (HUS1)

The protein encoded by HUS1 is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. Zusätzlich bieten wir Ihnen HUS1 Antikörper (60) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte HUS1 HUS1 498411  
HUS1 3364 O60921
HUS1 15574 Q8BQY8
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Showing 10 out of 10 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
Details
Escherichia coli (E. coli) Human His tag 10 μg Anmelden zum Anzeigen 15 bis 19 Tage
$319.00
Details
Hefe Schizosaccharomyces pombe His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,755.50
Details
Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Anmelden zum Anzeigen 11 Days
$341.00
Details
Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$385.00
Details
Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$225.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
Details
Escherichia coli (E. coli) Human Unkonjugiert   10 μg Anmelden zum Anzeigen 2 bis 3 Tage
$364.64
Details

HUS1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine)

Weitere Proteine zu HUS1 Checkpoint Homolog (S. Pombe) (HUS1) Interaktionspartnern

Human HUS1 Checkpoint Homolog (S. Pombe) (HUS1) Interaktionspartner

  1. These results suggest that p21(Waf1/CIP1 (zeige CDKN1A Proteine)) and Hus1 play crucial roles in the generation and transmission of bystander damage signals after low-dose alpha-particle irradiation.

  2. adenine glycosylase activity, mismatch recognition properties and interaction with protein partners of MUTYH (zeige MUTYH Proteine) and 5 MAP variants were examined; P502L and R520Q had reduced affinity for PCNA (zeige PCNA Proteine); only Q324H was found to have reduced affinity for Hus1

  3. Intramolecular binding of the rad9 (zeige RAD9A Proteine) C-terminus in the checkpoint clamp (zeige PDZK1 Proteine) Rad9 (zeige RAD9A Proteine)-Hus1-Rad1 is closely linked with its DNA binding.

  4. these pockets were not required for 9-1-1 chromatin localization or ATR (zeige ANTXR1 Proteine)-mediated CHK1 (zeige CHEK1 Proteine) activation but were necessary for interactions between HUS1 and its binding partner MYH (zeige MUTYH Proteine)

  5. Expression of cell cycle regulatory factors hus1, gadd45a (zeige GADD45A Proteine), rb1 (zeige RB1 Proteine), cdkn2a and mre11a (zeige MRE11A Proteine) correlates with expression of clock gene per2 (zeige PER2 Proteine) in human colorectal carcinoma tissue.

  6. HUS1 polymorphisms act as risk breast cancer modifiers in the group of non-carriers of BRCA1/2 mutations.

  7. Data show models for the ternary PCNA (zeige PCNA Proteine)/FEN1 (zeige FEN1 Proteine)/DNA and Rad9 (zeige RAD9A Proteine)-Rad1-Hus1 (9-1-1 complex)/FEN1 (zeige FEN1 Proteine)/DNA assemblies.

  8. The HUS1 is loaded to damaged sites where it serves as a platform for the selective recruitment of checkpoint and repair proteins.

  9. The HUS1 protein interacts with casein kinase 2.

  10. Rad9 (zeige RAD9A Proteine)-Rad1-Hus1 complex enhances in vitro activity of 8-oxoguanine DNA glycosylase (zeige OGG1 Proteine).

Mouse (Murine) HUS1 Checkpoint Homolog (S. Pombe) (HUS1) Interaktionspartner

  1. Whereas Hus1(neo/neo) and Atm(-/-) single mutant mice survived low-dose MMC similar to wild-type controls, Hus1(neo/neo)Atm(-/-) double mutants showed striking MMC hypersensitivity.

  2. Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1

  3. HUS1 acts as a component of the canonical 9-1-1 complex during meiotic prophase I to promote DSB repair and further propose that RAD1 (zeige RAD1 Proteine) and TOPBP1 (zeige TOPBP1 Proteine) respond to unsynapsed chromatin through an alternative mechanism that does not require RAD9 (zeige RAD9A Proteine) or HUS1.

  4. requirement for Hus1 in the survival and proliferation of mammary epithelium

  5. Hus1 is required specifically for one of two separable mammalian checkpoint pathways that respond to distinct forms of genome damage during S phase.

  6. Hus1-deficient mouse cells had an impaired S checkpoint after exposure to DNA strand break-inducing agents such as camptothecin or ionizing radiation

  7. we show a requirement for Rad17 and Hus1 to induce G(2) arrest as well as Vpr-induced phosphorylation of histone 2A variant X (H2AX) and formation of nuclear foci containing H2AX and breast cancer susceptibility protein 1

  8. results indicate that the role of Hus1 affecting the sensitivity of cells to IR-induced killing is independent of nonhomologous end-joining but might be linked to homologous recombination repair

  9. Hus1 loss leads to chromosomal instability during DNA replication, triggering increased apoptosis and impaired proliferation through p53 (zeige TP53 Proteine)-independent mechanisms.

  10. identify differential effects of altered Hus1 gene dosage on genome maintenance during in vitro culture, genotoxic stress responses, embryonic development, and adult homeostasis

HUS1 Protein Überblick

Protein Überblick

The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit HUS1

  • HUS1 checkpoint clamp component (Hus1)
  • HUS1 checkpoint clamp component (HUS1)
  • hHUS1 Protein
  • mHus1 Protein

Bezeichner auf Proteinebene für HUS1

Hus1 homolog , checkpoint protein HUS1 , hus1+-like protein

GENE ID SPEZIES
498411 Rattus norvegicus
3364 Homo sapiens
15574 Mus musculus
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