anti-HUS1 Checkpoint Homolog (S. Pombe) (HUS1) Antikörper

The protein encoded by HUS1 is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. Zusätzlich bieten wir Ihnen HUS1 Proteine (13) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
HUS1 498411  
HUS1 3364 O60921
HUS1 15574 Q8BQY8
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Showing 10 out of 59 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert WB HUS1 Antibody (C-term)  western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the HUS1 antibody detected the HUS1 protein (arrow). 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
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Human Kaninchen Unkonjugiert IC, IF, IHC, WB Immunofluorescent analysis of HUS1 staining in K562 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody i Immunohistochemical analysis of HUS1 staining in human kidney formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the a 200 μL Anmelden zum Anzeigen 11 bis 13 Tage
464,29 €
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Human Kaninchen Unkonjugiert IF, IHC, WB 100 μL Anmelden zum Anzeigen 12 Days
261,90 €
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Human Kaninchen Unkonjugiert IHC (p), IHC, WB Western Blot: HUS1 Antibody [NBP1-33589] - 30 ug C8D30 whole cell lysate/extract 12 % SDS-PAGE gel, antibody dilution 1:1000. Western Blot: HUS1 Antibody [NBP1-33589] - Sample (30 ug of whole cell lysate) A: 293T 12% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Anmelden zum Anzeigen 2 bis 4 Tage
341,00 €
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: HUS1 Antibody [NBP1-89445] - Staining of human cell line U-2 OS shows positivity in golgi apparatus. Western Blot: HUS1 Antibody [NBP1-89445] - HUS1 antibody image was provided by Dr. A-Lien Lu-Chang at Department of Biochemistry & Molecular Biology, University of Maryland School of Medicine. 0.1 mL Anmelden zum Anzeigen 5 bis 8 Tage
335,00 €
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Human Kaninchen Unkonjugiert IHC (p), WB WB Image HUS1 antibody detects HUS1 protein by Western blot analysis. A. 30 µg C8D30 whole cell lysate/extract 12 % SDS-PAGE HUS1 antibody , dilution: 1:1000 IHC-P Image HUS1 antibody detects HUS1 protein at cytosol and nucleus on rat fore brain by immunohistochemical analysis. Sample: Paraffin-embedded rat fore brain. HUS1 antibody , dilution: 1:500. 100 μL Anmelden zum Anzeigen 5 bis 7 Tage
357,24 €
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Human Kaninchen Unkonjugiert IP, WB Immunoprecipitation of HUS1 transfected lysate using anti-HUS1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with HUS1 purified MaxPab mouse polyclonal antibody (B01P) . Western Blot analysis of HUS1 expression in transfected 293T cell line by HUS1 MaxPab polyclonal antibody.Lane 1: HUS1 transfected lysate(31.70 KDa).Lane 2: Non-transfected lysate. 100 μL Anmelden zum Anzeigen 7 bis 8 Tage
358,40 €
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Human Kaninchen Unkonjugiert IHC (p), WB   100 μL Anmelden zum Anzeigen 11 bis 14 Tage
600,64 €
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Human Maus Unkonjugiert IP, ELISA Detection limit for recombinant GST tagged HUS1 is 0.1 ng/ml as a capture antibody. Immunoprecipitation of HUS1 transfected lysate using anti-HUS1 monoclonal antibody and Protein A Magnetic Bead , and immunoblotted with HUS1 MaxPab rabbit polyclonal antibody. 100 μg Anmelden zum Anzeigen 7 bis 8 Tage
369,60 €
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Human Maus Unkonjugiert IP, ELISA   100 μg Anmelden zum Anzeigen 11 bis 14 Tage
635,55 €
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HUS1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Rat (Rattus)


Human ,
,
,
, , , , ,
Mouse (Murine)


Weitere Antikörper gegen HUS1 Interaktionspartner

Human HUS1 Checkpoint Homolog (S. Pombe) (HUS1) Interaktionspartner

  1. These results suggest that p21(Waf1/CIP1 (zeige CDKN1A Antikörper)) and Hus1 play crucial roles in the generation and transmission of bystander damage signals after low-dose alpha-particle irradiation.

  2. adenine glycosylase activity, mismatch recognition properties and interaction with protein partners of MUTYH (zeige MUTYH Antikörper) and 5 MAP variants were examined; P502L and R520Q had reduced affinity for PCNA (zeige PCNA Antikörper); only Q324H was found to have reduced affinity for Hus1

  3. Intramolecular binding of the rad9 (zeige RAD9A Antikörper) C-terminus in the checkpoint clamp (zeige PDZK1 Antikörper) Rad9 (zeige RAD9A Antikörper)-Hus1-Rad1 (zeige ERCC4 Antikörper) is closely linked with its DNA binding.

  4. these pockets were not required for 9-1-1 chromatin localization or ATR (zeige ANTXR1 Antikörper)-mediated CHK1 (zeige CHEK1 Antikörper) activation but were necessary for interactions between HUS1 and its binding partner MYH (zeige MUTYH Antikörper)

  5. Expression of cell cycle regulatory factors hus1, gadd45a (zeige GADD45A Antikörper), rb1 (zeige RB1 Antikörper), cdkn2a (zeige CDKN2A Antikörper) and mre11a (zeige MRE11A Antikörper) correlates with expression of clock gene per2 (zeige PER2 Antikörper) in human colorectal carcinoma tissue.

  6. HUS1 polymorphisms act as risk breast cancer modifiers in the group of non-carriers of BRCA1/2 mutations.

  7. Data show models for the ternary PCNA (zeige PCNA Antikörper)/FEN1 (zeige FEN1 Antikörper)/DNA and Rad9 (zeige RAD9A Antikörper)-Rad1 (zeige ERCC4 Antikörper)-Hus1 (9-1-1 complex)/FEN1 (zeige FEN1 Antikörper)/DNA assemblies.

  8. The HUS1 is loaded to damaged sites where it serves as a platform for the selective recruitment of checkpoint and repair proteins.

  9. The HUS1 protein interacts with casein kinase 2.

  10. Rad9 (zeige RAD9A Antikörper)-Rad1 (zeige ERCC4 Antikörper)-Hus1 complex enhances in vitro activity of 8-oxoguanine DNA glycosylase (zeige OGG1 Antikörper).

Mouse (Murine) HUS1 Checkpoint Homolog (S. Pombe) (HUS1) Interaktionspartner

  1. Whereas Hus1(neo/neo) and Atm(-/-) single mutant mice survived low-dose MMC similar to wild-type controls, Hus1(neo/neo)Atm(-/-) double mutants showed striking MMC hypersensitivity.

  2. Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1

  3. HUS1 acts as a component of the canonical 9-1-1 complex during meiotic prophase I to promote DSB repair and further propose that RAD1 (zeige RAD1 Antikörper) and TOPBP1 (zeige TOPBP1 Antikörper) respond to unsynapsed chromatin through an alternative mechanism that does not require RAD9 (zeige RAD9A Antikörper) or HUS1.

  4. requirement for Hus1 in the survival and proliferation of mammary epithelium

  5. Hus1 is required specifically for one of two separable mammalian checkpoint pathways that respond to distinct forms of genome damage during S phase.

  6. Hus1-deficient mouse cells had an impaired S checkpoint after exposure to DNA strand break-inducing agents such as camptothecin or ionizing radiation

  7. we show a requirement for Rad17 and Hus1 to induce G(2) arrest as well as Vpr-induced phosphorylation of histone 2A variant X (H2AX) and formation of nuclear foci containing H2AX and breast cancer susceptibility protein 1

  8. results indicate that the role of Hus1 affecting the sensitivity of cells to IR-induced killing is independent of nonhomologous end-joining but might be linked to homologous recombination repair

  9. Hus1 loss leads to chromosomal instability during DNA replication, triggering increased apoptosis and impaired proliferation through p53 (zeige TP53 Antikörper)-independent mechanisms.

  10. identify differential effects of altered Hus1 gene dosage on genome maintenance during in vitro culture, genotoxic stress responses, embryonic development, and adult homeostasis

HUS1 Antigen-Profil

Protein Überblick

The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit HUS1

  • HUS1 checkpoint homolog (S. pombe) (Hus1) Antikörper
  • HUS1 checkpoint homolog (S. pombe) (HUS1) Antikörper
  • Hus1 homolog (S. pombe) (Hus1) Antikörper
  • hHUS1 Antikörper
  • mHus1 Antikörper

Bezeichner auf Proteinebene für HUS1

Hus1 homolog , checkpoint protein HUS1 , hus1+-like protein

GENE ID SPEZIES
498411 Rattus norvegicus
3364 Homo sapiens
15574 Mus musculus
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